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Language Medicina oral, patología oral y cirugía bucal. Ed inglesa. 2025. Vol. 30, no. 04
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- Evaluation of ultrasonographic features of major salivary glands and oral manifestations in patients with Sjögren's Syndrome(2025) Taşkın, Betül; Goller Bulut, Duygu; Taşçı, MuratSjögren's Syndrome (SS) is an autoimmune disease characterized by the involvement of exocrine glands and leading to various oral manifestations. The present study aimed to investigate the relationships between the salivary glands' ultrasonographic findings, the frequency of oral manifestations, the DMFT index and the unstimulated salivary flow rate in patients diagnosed with SS and to compare these parameters with healthy controls. The ultrasonographic findings of the parotid and submandibular glands in 43 patients with SS were evaluated according to the Hocevar and Milic scoring system. The frequency of oral manifestations, the unstimulated salivary flow rate, and the DMFT index were calculated and the relationships between these parameters were examined. The ultrasonography findings and the DMFT index of SS patients were compared with the 43 healthy control group. The total Hocevar and Milic scores were higher in the patients than in the controls (p0.1 ml/min. A positive correlation was observed between ultrasonography scores and DMFT in the patients (p<0.05). The mean total Hocevar score was found to be higher in submandibular gland than in the parotid gland (p=0.042). The increase in salivary gland ultrasonography scores in SS correlated with a decrease in unstimulated salivary flow rate, an increase in the DMFT index and some oral manifestations. Ultrasonography scores showed that, in the early stages of SS, the submandibular gland parenchyma was more affected than the parotid gland. The diagnosis of SS is difficult, and dentists can play an important role in the early diagnosis of the disease by evaluating the oral manifestations and ultrasonography findings.
- Brazilian oral medicine and oral pathology: international scientific collaborations(2025) Ferreira, Luiz Miguel; Nascimento, João Pedro Santos; Trezena, Samuel; Maia-Lima, Marcos Paulo; Sobral, Layanne; Alencar, Ana Maria; Martelli, Daniela Reis Barbosa; Lopes, Márcio Ajudarte; Pires, Fábio-Ramôa; Martelli Júnior, HercílioResearch in Oral Medicine (OM) and Oral Pathology (OP) in Brazil has experienced remarkable growth, gaining international recognition. However, no analysis has evaluated the patterns of evolution of international partnerships and their role in advancing Brazilian research in these areas. This study analyzed collaborations between Brazilian and international researchers in OP/OM. A bibliometric cross-sectional survey was conducted using data from Brazilian researchers in OP/OM, identified through the Brazilian Society of Stomatology and Maxillofacial Pathology. Researchers' curriculum on the Lattes platform were analyzed, and data on publications, citations, co-authorships, affiliations, and journals were collected from the Scopus database, focusing on international collaborations. Bibliometric analyses were performed using the Bibliometrix tool in R Studio and VOSviewer software. Statistical trends between decades were compared using the Kruskal-Wallis test. The sample included 229 researchers, most females (61.6%), affiliated with public institutions (78.9%), and with a mean time since achieving the PhD of 15.27 years. Almost half of the researchers (43.2%) had postdoctoral training, and among them 43.4% completed it abroad, mainly in the United States (USA), Canada, and the United Kingdom (UK). A total of 2,027 articles were analyzed, revealing a 10.53% annual growth in publications. The number of international collaborations significantly increased over decades (p < 0.001), with USA, UK, India, and Italy being the leading partners. Collaborative publications showed a significant rise in citations (42.61 per paper), mainly in high-impact journals. A steady increase in international collaborations in OP/OM was identified, especially with the USA and the UK. These partnerships have increased citations and publications in high-impact journals, which highlights their benefit and importance for research in these areas.
- Risk factors associated with prognosis in patients with osteoradionecrosis of the jaws: A single institutional experience over 15 years(2025) Li, Chen-xi; Gong, Zhong-cheng; Jumatai, Sakendeke; Fang, Chang; Pataer, Parekejiang; Zhao, Hua-rongOsteoradionecrosis of the jaws (ORNJ) is a pernicious complication of radiation therapy that significantly affects the quality of life of patients with head and neck cancer. The present study aimed to investigate the risk factors for the clinical prognosis of ORNJ in the same scenario. A cross-sectional study was designed and implemented in a tertiary teaching hospital from January 2005 to December 2020. A total of 106 patients were divided into normal wound healing group (n = 79) and delayed wound healing group (n = 27) according to two different prognosis. The risk factors associated with the prognosis in patients with ORNJ were comparatively analyzed via performing one-way and multifactorial logistic analyses. The majority of the study cohort (n = 59, 55.7%) was found to be characterized with Glanzmann and Gratz grade 2 and followed up for a median of 38.6 months. Diabetes mellitus (P = .045), Charlson comorbidity index (P = .042), American Society of Anesthesiologists score (P < .001), primary tumour site (P = .012), T stage (P = .008), ORNJ grade at initial diagnosis (P < .001), pan-immune-inflammatory value and systemic immune-inflammatory index at initial radiotherapy (P = .01 and P < .001 respectively) were detected as risk factors associated with poor prognosis in patients with ORNJ. We conclude that there are abundant risk factors for poor prognosis in these patients, and it is important to be evaluated before irradiation so that suiTable post-radiated treatments can be given.
- Is lingual fracture pattern in sagittal split osteotomy associated with recovery of neurosensory disturbance?(2025) Kaba, Yusuf Nuri; Eren, Cemil; Demirbas, Ahmet E.; Yaşar, Bahadır Gökberk; Soylu, Emrah; Gayıbov, NizamiBilateral sagittal split osteotomy (BSSO) is commonly used to correct mandibular deformities but may cause neurosensory disturbance (NSD) of the lower lip due to potential injury to the inferior alveolar nerve (IAN). The purpose of this study was to evaluate the effect of LSS 3 on postoperative neurosensory disturbances. The hypothesis of this study was that the LSS 3 split pattern would extend the recovery time of neurosensory disturbance. The retrospective cohort study included patients who underwent BSSO surgery in Erciyes University, Oral and Maxillofacial Surgery Hospital. The primary predictor variable was the lingual split pattern. The split patterns were categorized using the Lingual Split Scale (LSS). The primary outcome was NSD. The postoperative sensation was assessed using a visual analogue scale (VAS). The secondary outcome was intraoperative nerve exposure. The nerve exposure was classified as No nerve encountered, Embedded in distal segment, Embedded in proximal segment and Nerve transected. All data were analyzed using Turcosa Cloud statistical software (Turcosa Ltd. Co., Turkey). p<0.05 was considered significant. The study included 101 patients with 202 split sides. LSS 1 was the most common pattern (63.37%), followed by LSS 3 (25.74%). In LSS 3 split pattern, the inferior alveolar nerve mostly embedded in the proximal segment (p<0.05). NSD was highest in LSS 3 cases, particularly in the first 6 months postoperatively (p<0.05). However, no significant differences were observed after 12 months. LSS 3 splits may significantly increase embedded in the proximal segment and can associated with higher postoperative NSD, particularly in the first 6 months. Surgeons should consider factors contributing to LSS 3 patterns to reduce the risk of NSD.
- Inferior alveolar nerve damage related to dental implant placement. A systematic review and meta-analysis(2025) Peña Cardelles, Juan Francisco; Markovic, Jovana; Akhondi, Samuel; Pedrinaci, Ignacio; Lanis, Alejandro; Gallucci, German O.A concern associated with implant placement is the potential occurrence of neurovascular lesions and subsequent development of sensory alterations in patients undergoing implant placements. The objective of this review is to evaluate the incidence of neurosensory alterations based on the proximity between the implant and the mandibular canal A systematic review was conducted in MEDLINE, Web of Science, and Scopus. Studies with common variables were selected to conduct a meta-analysis. The patient classification was based on the mandibular canal-implant distance. Neurosensory alteration percentages were calculated for each study and group. The findings indicate significant correlations between implant placement proximity and neurosensory risks. The incidence of neurosensory alterations in patients with implants placed at a distance ≥ 2 mm from the mandibular canal was 0%. Similarly, for distances between 1-2 mm from the mandibular canal, the incidence remained at 0%. However, for implants placed at a distance of 0-1 mm from the mandibular canal, the incidence of neurosensory alterations was 68%. Additionally, patients with implants that intruded into the canal had an incidence of 53% in the development of neurosensorial alterations. A distance of 1 mm from the mandibular canal might be safe. Implants placed at a distance less than 1 mm from the mandibular canal exhibit neurosensory alterations. Clinicians should be aware of the potential risk of nerve injury and adopt appropriate precautions, including meticulous preoperative planning and three-dimensional radiographic images.
- Periodontitis as a risk factor for colorectal cancer: systematic review and meta-analysis(2025) Espejo-Carrera, Rosita Elena; Honores-Solano, Tammy Margarita; Ulloa-Cueva, Teresa Verónica; Caballero Alvarado, Jose; Minchón, Carlos Alberto; Asmat Abanto, Angel StevenPrimary studies on the association between periodontitis and colorectal cancer (CRC) may have insufficient statistical power to reach a reliable conclusion. In this regard, the present systematic review and meta-analysis were conducted to determine whether periodontitis is a risk factor for CRC. A systematic search was carried out in five databases, which included cohort and case-control studies published up to July 3, 2024, in which periodontitis was evaluated as a risk factor for CRC using relative risk (RR), hazard ratio (HR) or odds ratio (OR). The Newcastle-Ottawa Scale (NOS) was used to assess the risk of bias, and the GRADE system was used to determine the certainty of the evidence. Of 1476 articles retrieved, 8 cohort studies were included for qualitative analysis and meta-analysis. The overall synthesis showed that periodontitis is not a risk factor for CRC (RR=1.34; 95% CI: 0.96-1.89; p<0.09; I2=95%). In addition, subgroup analyses were performed according to gender, periodontitis diagnostic methods, and risk of bias, which led to the finding of an increased risk of CRC of 32% only for men with periodontitis (RR=1.32; 95% CI: 1.16-1.50; p<0.00001; I2=0%). Periodontitis is not a risk factor for CRC, with very low certainty of evidence. However, the analysis of subgroups by gender showed that it is a risk factor for CRC in men, with moderate certainty of evidence.
- Strategies for rehabilitation management with implants in patients with down syndrome: a scoping review(2025) Dethlefs-Canto, Jessika; Baeza, Solange; Ormeño-Sepúlveda, Daniela; Bustos Ponce, AlexisDown Syndrome (DS), caused by an extra chromosome 21, has a prevalence of 24.7 per 10,000 live births in Chile, the highest in Latin America. Individuals with DS commonly present orofacial and dental anomalies, complicating oral health management. Many depend on removable prostheses, which represent challenges in hygiene, handling, and adaptation. Dental implants are a promising alternative, offering improved stability and functionality. However, successful rehabilitation requires addressing specific anatomical, physiological, and behavioral considerations. This scoping review compiles evidence-based strategies to guide implant treatment in this population. Registered on the Open Science Framework (https://osf.io/bstwk/), this review followed the PRISMA-ScR protocol, addressing the question: "Which are the management strategies and survival rates of dental implants in patients with Down Syndrome?" Searches were conducted in Pubmed/MEDLINE, Scopus, Science Direct, Web of Science, and Ebsco databases. Of 92 studies identified, 7 met inclusion criteria, encompassing 179 implants in DS patients. Anesthesia type varied based on patient cooperation and procedure complexity: general anesthesia for uncooperative patients, local anesthesia for compliant individuals, and sedation for intermediate cases. Delayed loading (3-12 months) yielded better outcomes than immediate loading. Overdentures with locator or bar systems were effective and easier to maintain, while screw-retained fixed prostheses provided stability but required strict hygiene adherence. Clinical success rates varied, with higher success in simple cases and higher failure rates in studies involving multiple implants. Dental implants, combined with structured behavioral management, improve oral rehabilitation outcomes in DS patients. While sedation or general anesthesia may be required, associated risks must be carefully managed. Delayed implant loading is recommended to minimize osseointegration failures. An interdisciplinary approach, including material selection, caregiver education, and long-term maintenance, is essential for successful, individualized outcomes.
- Comparative analysis of language models in addressing syphilis-related queries(2025) Ferreira, Luiz Miguel; Nascimento, João Pedro Santos; de Souza, Lucas-Lacerda; de Souza, Fabrício Tinôco Alvim; Guimarães, Letícia Drumond de Abreu; Lopes, Márcio Ajudarte; Vargas, Pablo Agustín; Martelli Júnior, HercílioSyphilis, caused by Treponema pallidum, is a significant global health concern with potentially severe complications if untreated. Advances in artificial intelligence (AI), particularly large language models (LLMs), offer opportunities to enhance medical diagnosis and public health education. This study aims to assess LLMs' ability to provide readable, accurate, and comprehensive syphilis information by comparing it with WHO datasheets and validating through specialist evaluation for clinical relevance. Ten AI-based LLMs were evaluated. Ten questions addressing symptoms, transmission, diagnosis, treatment, and prevention were crafted by researchers. Responses from the LLMs were compared to World Health Organization (WHO) syphilis fact sheets, and a panel of specialists assessed the accuracy, clinical relevance, and readability of the AI-generated information. Among the evaluated LLMs, ChatGPT 4.0 and Claude demonstrated the highest accuracy, scoring 92% and 89% alignment with WHO standards, respectively. Perplexity and Llama3 performed less reliably, with scores between 60-70%, especially in areas like tertiary syphilis and neurosyphilis. Specialists identified common errors, such as outdated treatment protocols and incorrect descriptions of transmission pathways. Expert reviews further revealed that while LLMs provided adequate information on early syphilis symptoms, they struggled with complex clinical nuances. The specialists' evaluation showed that only 60% of the AI-generated content was deemed clinically reliable without further edits, with ChatGPT 4.0 rated highest by experts in terms of readability and clinical accuracy. LLMs hold promise for disseminating syphilis information, but human oversight is crucial. AI models need refinement to improve their accuracy, especially in complex medical scenarios.
- Oral cancer awareness and knowledge among patients attending an oncological screening program in Portugal(2025) Andrade, Margarida; Pereira, Diogo; García Paredes, Beatriz; Moreira, André; Caramés, Joao; Pojo, Marta; Freitas, FilipeThe aim of this study was to evaluate the awareness and knowledge about oral cancer in a Portuguese population and to assess its possible relations with sociodemographic variables. A cross-sectional questionnaire survey was conducted, with 2650 individuals that attended oncological screening initiatives in the southern region of Portugal. The questionnaire collected data on participants’ socio-demographic information, life-style habits, and awareness of oral cancer. Over four-fifths of the participants (83.4%) mentioned that had already heard about oral cancer. Knowledge of oral cancer was significantly associated with age (p = 0.034), education level (p < 0.001), frequency of dentist visits (p < 0.001), and smoking (p = 0.015) and alcohol habits (p = 0.031). Regarding risk factors, smoking and alcohol usage were identified by 86% and 58.5% of the sample, respectively. Only 62.8%, 45.5%, and 37.9%, respectively, were able to correctly identify ulcers that don’t heal, red and white lesions, and lumps/tissue that overgrows as early signs of oral cancer. A general lack of awareness regarding oral cancer was found in this Portuguese population. Lower levels of knowledge were found in individuals of higher risk for oral cancer. Therefore, educational programs targeting the risk population are highly recommended for the primary prevention and early diagnosis of oral cancer in the Portuguese population.
- Outcomes of removing the fracture fragments in the treatment of intracapsular condylar fractures in children(2025) Dai, Jia-Wei; Gong, Chao; Diarra, Drissa; Li, ZhiTreatment methods for mandibular condylar fractures in children can be broadly divided into closed treatment and open treatment (open reduction and internal fixation). The aim of the study is to evaluate the feasibility of removing the fracture fragments when treating intracapsular condylar fractures in children. A retrospective study was performed in patients aged ≤12 years with intracapsular condylar fractures treated with removal of the fracture fragments from June 2010 through June 2018. The preoperative and postoperative data of physical complaints, facial asymmetry, maximal interincisal distance, occlusal relationship and radiographic examinations were extracted from the patients’ records. The collected preoperative and postoperative data were analysed. Thirteen intracapsular condylar fractures in nine cases were subjected to fracture fragments removal. In these patients, clinical and radiographic results at different follow-up periods displayed normal occlusion and satisfactory bone healing. New condyles were found to be regenerated, in the cases with follow-up period longer than 3 months. Removal of fracture fragments proves to be effective in delivering satisfactory clinical results and permitting ongoing condyle remodelling and regeneration.
- Finite element analysis of shape and thickness variations in patient-specific implants for t-shaped genioplasty(2025) Akkoyun, Emine Fulya; Pergel, TahaT-shaped genioplasty is a versatile surgical technique used to correct chin deformities by altering its vertical, transverse, and sagittal dimensions. Despite numerous advancements in patient-specific implants (PSIs), the biomechanical impact of PSI thickness and the number of screws used for fixation remain unexplored. This study aims to evaluate the effects of PSI thickness and screw conFigurations on fixation stability in T-shaped genioplasty using finite element analysis. Mandibular computed tomography data were used to construct 12 three-dimensional models with varying PSI thicknesses (0.6 mm, 0.9 mm, and 1.2 mm) and screw conFigurations (five, six, seven, and eight screws). T-shaped osteotomies were applied to create narrowing and widening genioplasty models, with iliac bone grafts placed in widening scenarios. Horizontal forces of 50 N were applied bilaterally, and fixation stability was evaluated using von Mises stress and bone displacement. Fixation was considered sTable when bone displacement amounts were below 1 mm. In narrowing models, fixation stability was achieved with five screws and a 1.2 mm PSI or seven screws with a 0.9 mm or 1.2 mm PSI, showing stress values within titanium's yield strength limits. For widening models, sTable fixation was achieved with six screws and a 0.9 mm or 1.2 mm PSI, or eight screws across all tested thicknesses. Bone displacement was minimal with thicker PSIs and higher screw counts, demonstrating improved stability. This study highlights the importance of PSI customization in optimizing fixation stability in T-shaped genioplasty. A minimum of five screws with a 1.2 mm plate or seven screws with a 0.9 mm plate is suggested for narrowing, while six screws with a 0.9 mm plate or eight screws with any tested thickness are sufficient for widening. Future research should address combined movements, dynamic loading, and long-term outcomes to refine PSI fixation strategies further.
- Trigeminocardiac reflex in bimaxillary orthognathic surgery: case review(2025) Ortiz Peces, Luis; Álvaro-Martinez, María; Moreiras Sánchez, Álvaro Damián; Chacón-Ferrer, Guillermo; Andura-Correas, Martín; Castillo Pardo de Vera, José Luis del; Ortiz González, Luis; Cebrián Carretero, José LuisThe trigeminocardiac reflex (TCR) is a rare but clinically significant phenomenon characterized by bradycardia, hypotension, or asystole triggered by trigeminal nerve stimulation during maxillofacial surgery. It necessitates prompt recognition and management to ensure patient safety. TCR has been reported in orthognathic surgery, particularly during specific surgical maneuvers. We report the case of a 36-year-old male who experienced TCR during bimaxillary orthognathic surgery. Detailed documentation of the patient’s clinical characteristics, intraoperative events, and management strategies was included. Additionally, we conducted a systematic review of the literature using Medline, Embase, Web of Science, and Scopus databases to identify cases of TCR in orthognathic surgery published from 1989 onward. Keywords included "trigeminocardiac reflex," "orthognathic surgery," "Le Fort I," and "bilateral sagittal split osteotomy". We present the case of a patient who experienced transient bradycardia and asystole during mandibular manipulation and pterygomaxillary disjunction. The episode was successfully managed with atropine and cessation of triggering maneuvers. Additionally, a systematic review identified 10 cases of TCR in orthognathic surgery, most of which occurred during Le Fort I osteotomies, particularly during maxillary downfracture, followed by bilateral sagittal split osteotomies. Common manifestations included bradycardia and asystole. Management strategies involved cessation of surgical stimuli, administration of anticholinergic agents, and, in one severe case, cardiopulmonary resuscitation. TCR in orthognathic surgery is a significant risk requiring vigilance and prompt management. Understanding its triggers, maintaining intraoperative monitoring, and employing preventive strategies, such as gentle manipulation and proper anesthesia protocols, are essential for optimizing patient safety.
- Novel approach in the resection of oral maxillary tumours(2025) Cea Arestín, Pablo; Bilbao Alonso, Arturo; García García, Abel; Menéndez-Lago, CarolinaOral cavity tumours represent a global oral health issue due to their prevalence and incidence, in this paper, we will explain the procedure for the removal of various tumours and the restoration of the patient's anatomy, function and aesthetics through a novel approach that rely on a temporal muscle flap for the reconstruction of soft tissues in the surgical area. This study is based on an analysis of temporal flap technique data, collected at the public health hospital of Santiago de Compostela (CHUS), from 2015 to 2024. The results are shown in Table 1, being the most relevant data the fact of having a series of 11 successful cases treated with temporal flap. The surgical technique involves tumor resection, preferably through an intraoral approach. This novel technique must be taken into account when solving this type of oncological cases with associated maxillectomy due to it’s better results in terms of reconstruction of tissues and anatomy, shorter execution time and possibility of offering immediate function to the patient, leading to less number of surgeries with their consequent lower morbidity and social-health and economic savings.
- Does the use of proton pump inhibitors lead to an increased risk of dental implant failure? A systematic review and meta-analysis(2025) Tang, Mingchun; Xie, ZhiminProton-pump inhibitors (PPI) are one of the commonly used medications for a variety of gastrointestinal disorders. Given the large population using PPI and the increased use of dental implants in recent times, it is pertinent to examine if PPI impacts implant outcomes. This systematic review examined the risk of implant failure amongst PPI users vs non-users. PubMed, Embase, Scopus, and Web of Science literature databases were scouted for cohort or case-control studies comparing implant survival between PPI users vs non-users. Last date of the literature search was 30th October 2024. We identified eight studies for inclusion. Both crude and adjusted data were pooled separately. Meta-analysis of crude data demonstrated that there was a statistically significant risk of implant failure in PPI users as compared to non-users (OR: 2.71 95% CI: 1.72, 4.29 I2 = 63%). These results failed to change on sensitivity analysis. Pooled analysis of adjusted data showed that PPI use may not independently predict implant failure (OR: 1.44 95% CI: 0.92, 2.24 I2 = 73%). Exclusion of one outlier study showed a significantly increased risk of implant failure with PPI use (OR: 1.71 95% CI: 1.17, 2.50 I2 = 42%). There may be a tendency for higher implant failure in patients using PPI. The lack of stability of the results on sensitivity analysis and non-significant associations noted with adjusted data preclude strong conclusions. There is a need for further high-quality studies to strengthen the available evidence.
- Survival rate and marginal bone loss in titanium vs titanium-zirconia single-unit narrow diameter implants. A systematic review and Meta-analysis of prospective studies(2025) Peña Cardelles, Juan Francisco; Akhondi, Samuel; Markovic, Jovana; Pala, Kevser; Lanis, Alejandro; Gallucci, German O.Implant-supported single-unit restorations present a predicTable and widely used treatment option to replace missing teeth. Narrow-diameter implants provide a viable treatment option for clinical scenarios with limited bone availability, minimizing the need for bone augmentation procedures. This systematic review aims to assess implant survival and implant marginal bone loss among different single-unit narrow implant diameters and between titanium single-unit and titanium-zirconia single-unit narrow implants. This article was structured according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA®) Included criteria were randomized clinical trials (RCTs) and clinical prospective studies with at least 10 patients, a mean follow-up period of at least 12 months, and assessing single-tooth implants with a diameter of 3.5 mm or less. Twelve included articles were prospective clinical studies, while 3 articles were randomized controlled clinical studies. There are no significant differences in the comparison between the 2.9-3.0 mm group and the 3.3-3.5 mm group (p=0.933). Both groups had a 99% survival (95% CI, 99.9%-100%). Titanium-zirconia implants presented a mean of marginal bone loss of -0,37 mm (CI, 95%: -0,53 to -0,20) meanwhile, titanium implants had a mean of marginal bone loss of -0,43 mm (CI95%:-0,71 to -0,28). The findings reveal no significant differences between 2.9-3.3mm and 3.3-3.5mm groups within narrow implants. Both titanium and titanium-zirconia alloys in narrow implants, exhibit comparable high survival rates and minimal marginal bone loss, showcasing their feasibility as a viable treatment alternative in scenarios with limited space or inadequate bone for regular diameter implants.
- Histological and morphometrical evaluation of non-critical bone defects after treatment with biomaterial and bisphosphonates(2025) Fernandes, Gustavo Vicentis Oliveira; Martins, Bruno Gomes dos Santos; Heboyan, Artak; Castilho, Rogerio M.; Fernandes, Juliana Campos HasseThe primary goal of this in vivo study was to ascertain if systemic bisphosphonates (BPs) positively affect bone repair in non-critical defects when assisted with a carbonated hydroxyapatite graft biomaterial (Biomat). Thirty-six female rats were allocated into two control groups (blood clot [BC] and alloplastic biomaterial); two groups with zoledronate (third-generation BPs): Zol.BP and Zol.BP+Biomat; and two groups with clodronate (first-generation BPs): Clod.BP and the Clod.BP+Biomat. The experimental groups started the application of BP 60 days before surgery. Then, a 2 mm non-critical defect was performed in the rats’ femur and filled according to the group. All animals were euthanized 30 days after surgery, and the samples were collected for histological and histomorphometry analysis, respectively, for descriptive and quantitative analyses. Zol.BP+Biomat had greater new bone formation, whereas clodronate presented high osteogenic potential, significantly increasing the observed levels of newly formed bone even in the absence of the biomaterial. Histomorphometrically, BC had 2% bone formation compared to the biomaterial group (5%). Zol.BP and Col.BP achieved bone formation of 6-fold (12%, p>0.05) and 9.5-fold (19%, p<0.05), respectively, when compared with BC. Zol.BP+Biomat group presented the highest value found for newly formed bone (24%), 12-fold more than BC (p<0.001) and 4.8-fold more than the biomaterial group (p<0.01). It is possible to conclude that the systemic use of BP positively affected non-critical bone defects when associated with biomaterials, mainly when the third generation of BPs was used in this association.
- Assessment of the prevalence of Behcet's disease in recurrent aphthous ulceration worldwide: a systematic review(2025) Azevêdo, Ana Beatriz; Veras Sobral, Ana Paula; Faria, Caroline Augusta Belo; Sousa, Juliana Syndia Silva Santos; da Silva, Weslay Rodrigues; Da Silveira, Márcia María FonsecaThe aim of this study was to evaluate the prevalence of Behcet's syndrome in patients with recurrent aphthous stomatitis (RAS). A search was performed in Scopus, Medline/PubMed, The Cochrane Library and Web of Science databases, according to PRISMA. In addition, a search was carried out in the DANS Easy Archive to access gray literature and a manual search in the reference list of included studies was used as an additional resource to refine the search. Cross-sectional studies in patients with recurrent aphthous stomatitis evaluating the diagnosis of Behcet's syndrome were analyzed to identify prevalence. The Joanna Briggs Institute (JBI) Critical Appraisal Checklist was used to assess the methodological quality of the articles. The study design, sample size, sex, International Study Group (ISG) diagnostic criteria and prevalence of the syndrome were evaluated. After screening and reading the articles in full, 7 met the inclusion criteria. The articles involved a total of 2841 participants with recurrent aphthous ulcerations, with 141 having a diagnosis of Behcet's syndrome. Studies were of good quality as assessed by the JBI Critical Appraisal Checklist for cross-sectional studies. The prevalence of Behcet's syndrome in patients with recurrent aphthous stomatitis (RAS) is generally low, with similar frequency in both sexes and more common in the range of countries that extends from the Mediterranean Basin to the Far East.
- Myofibromas of the jawbones in pediatric patients. A clinicopathological study(2025) Barajas-Torres, Guadalupe Carolina; Villanueva-Moreno, Norma Leticia; Rincón-Rodríguez, Héctor; Cuairán-Ruidiaz, Vicente; Márquez González, Horacio; Murillo-Eliosa, Juan Rafael; Mosqueda Taylor, AdalbertoMyofibromas are infrequent neoplasms that rarely occur in the jawbones. The aim of this study is to present a series of cases of these tumors affecting the jawbones in pediatric patients, as well as to describe their diagnostic methodology and therapeutic approach. retrospective study of a series of myofibromas of the jawbones diagnosed and treated in a single medical institution in Mexico City from 2002-2022. There were 14 cases with a median age of 6.5 years (IQR:1-12). Mandible was affected in 8 cases (57.1%), maxilla in 5 (35.8%) and only one case (7.1%) occurred in both jaws. Microscopically, the lesions were composed predominantly by spindle cells, as well as stellate and sometimes pleomorphic in shape, most of which were positive for smooth muscle actin. All cases were treated with complete excision of the lesion and only one presented recurrence. Once the diagnosis is confirmed and other spindle cell neoplasms have been excluded, resection with free margins represents the treatment of choice.
