Log In 
Language Medicina oral, patología oral y cirugía bucal. Ed inglesa. 2022. Vol. 27, no. 5
Permanent URI for this collection
Browse
Recent Submissions
- IL-10 and TGF-β1 gene polymorphisms in Greek patients with recurrent aphthous stomatitis(2022) Kounoupis, V.; Andreadis, D.; Georgaki, M.; Albanidou-Farmaki, E.; Daniilidis, M.; Markopoulos, A.; Karyotis, N.; Nikitakis, NG.; Poulopoulos, A.Recurrent aphthous stomatitis (RAS) is one of the most frequent inflammatory disorders of the oral mucosa. Cytokines, which play an important role in RAS pathogenesis, participate directly or indirectly in normal, immunological and inflammatory processes and are secreted from cells belonging to innate and adaptive immunity as a consequence of microbial and antigenic stimuli. Gene polymorphisms in specific cytokines may predispose to RAS development. The aim of this study was the investigation and association of IL-10 and TGF-β1 gene polymorphisms with RAS.
- Can adjunctive corticosteroid therapy improve patient-centered outcomes following third molar surgery? A systematic review(2022) Parhizkar, P.; Schmidlin, PR.; Bornstein, MM.; Fakheran, O.Third molar surgery is frequently associated with postoperative discomfort such as pain, edema and trismus. We aimed to evaluate the current evidence on the efficacy of adjunctive corticosteroid therapy in improving patient-centered outcomes following third molar surgery.
- The impact of COVID-19 on the practice of Oral and Maxillofacial Pathology in the United States and Canada(2022) Mutalik, VS.; Upadhyaya, J.; Lê, M.; Schönwetter, DJ.Background: The COVID-19 pandemic has significantly disrupted the delivery of healthcare, including oral healthcare services. The restrictions imposed for mitigating spread of the virus forced dental practitioners to adopt significant changes in their workflow pattern. The aim of this study was to investigate the impact of the pandemic on the practice of oral and maxillofacial pathology in two countries in regard to educational activities, and clinical and diagnostic pathology services.
- Letter to the editor: Triclosan in patients with inflammatory bowel disease(2022) Peña-Cardelles, JF.
- Association between socioeconomic factors and origin of hospital referrals among patients with oral cancer(2022) Raymundo, Maria-Letícia-Barbosa; Ferreira, Leonardo de Freitas; Gomes-Freire, Deborah E W; Freire, Aldelany R; Silva, Rennis O; de Araújo, Elza-Cristina-Farias; de Lucena, Edson Hilan Gomes; Cavalcanti, Yuri-WanderleyThe Brazilian Unified Health System (SUS) is responsible for offering free assistance to more than 100 million Brazilians, including treatment of oral cancer lesions. Considering that the Brazilian public system aids the most vulnerable population, this study analyzed whether the origin of hospital referrals of patients with oral cancer is associated with socioeconomic factors. A cross-sectional study was carried out from cancer hospital records of the National Cancer Institute (RHC-INCA), considering the primary locations (C00 to C06) diagnosed between 2016 and 2019. Data on gender, skin color (white and non-white), education (no schooling, incomplete or complete elementary education; high school; incomplete and complete higher education) and origin of referral (SUS and non-SUS) were analyzed by multiple logistic regression (p<0.05). Higher referral rates by the SUS were observed in 2017 (OR=1.27; 95% CI=1.098-1.480) and 2018 (OR=1.28; 95% CI=1.101-1.490); no differences were found between the years 2016 and 2019. Regarding gender, men were 40% more likely to have the SUS as the source of referral (OR=1.40; 95% CI=1.233-1.600). Non-white individuals were 34% more likely to have the SUS as the source of the referral (OR=1.34; 95% CI=1.190-1.512). Illiterate individuals or individuals who only attended elementary school were 6.38 times more likely to be referred by the SUS than individuals with higher education (OR=6.38; 95% CI=5.228-7.796). It is concluded that the origin of hospital referrals via SUS of patients with oral cancer is associated with socioeconomic factors.
- Letter to the editor:Triclosan in patients with inflammatory bowel disease(2022) Peña Cardelles, Juan FranciscoLetter to the editor
- Ep-CAM (MOC-31) expression in tooth germ and ameloblastoma(2022) Derderian, N.; Pereira-Prado, V.; Hernandez, M.; Isiordia-Espinoza, M.; Arocena, M.; González-González, R.; Tremillo-Maldonado, O.; Meleti, M.; Molina-Frechero, N.; Bologna-Molina, R.Ep-CAM, a transmembrane glycoprotein expressed in most epithelium in normal conditions, has diverse roles in these tissues, including in cell adhesion, proliferation, differentiation, cell cycle regulation, migration and intracellular signaling. It is also over-expressed in most malignant neoplasia, participating in the initiation, progression, and metastatic dissemination of the tumor. The expression and roles of this protein in oral neoplasia, particularly in odontogenic tumors, remain unestablished. The objective of this study consisted in analyzing the expression of this protein in ameloblastoma and tooth germ.
- The value of Phosphohistone H3 as a cell proliferation marker in oral squamous cell carcinoma. A comparative study with Ki-67 and the mitotic activity index(2022) Tancredi-Cueto, Natalia; Vigil, Gabriela; Bologna Molina, Ronell; Beovide?Cortegoso, VerónicaThe Phosphohistone H3 (PHH3) antibody is recognized as a biomarker of cell proliferation, specific for cells in mitosis, of prognostic value in different malignant neoplasms, however it has been poorly studied in oral squamous cell carcinoma (OSCC). The main objective of this study was to evaluate the immunoexpression of the PHH3 in the OSCC, through the correlation with the immunoexpression of Ki-67, the mitotic activity index (MAI), histological grading, clinical-morphological parameters and the rate of survival. The study sample consisted of 62 cases of OSCC diagnosed in the Pathological Anatomy Laboratory of the Faculty of Dentistry, University of the Republic (Uruguay). In each of them, an immunohistochemical technique was performed for Ki-67 and PHH3 (serine 10) antibodies. Image J software was used for the MAI and biomarker quantification, defining the percentage of positivity and mitotic Figures per 1000 tumor cells. a significant association was obtained between the expression of PHH3 (p 0.016) and MAI (p 0.031) with survival time. However, no similar relationship was found with Ki-67 (p 0.295). Although it was confirmed a statistical association between histological grade and Ki-67 immunoexpression (p 0.004), PHH3 did not show a similar relationship (p 0.564). It was confirmed the role of the PHH3 antibody as a biomarker of mitotic Figures in OSCC and as a potential marker of cell proliferation. It is noteworthy that this is one of the first works that evaluates a possible relationship between the expression of this antibody and survival in OSCC.
- Peripheral ossifying fibroma:a 20-year retrospective study with focus on clinical and morphological features(2022) Cavalcante, Israel Leal; Barros, Caio-César-da Silva; Cruz, Vitória Maria Sousa; Cunha, John Lennon Silva; Leão, Lara Cunha Carneiro; Ribeiro, Renata Roque; Turatti, Eveline; Andrade, Bruno Augusto Benevenuto de; Cavalcante, Roberta BarrosoPeripheral Ossifying Fibroma (POF) is a reactive hyperplastic lesion that exclusively occurs in the gingiva and is characterized by the deposition of dystrophic calcification, cementum-like tissue, and immature and mature bone within the connective tissue. The objective of the present study was to perform a retrospective analysis of clinicopathologic features of POF. Clinical and histopathological data were obtained from biopsy records and histopathological reports from a Brazilian reference service in Oral Pathology (1999 - 2020). Morphological analysis was performed to evaluate features related to the mesenchymal component, inflammatory infiltrate, ulceration, and mineralized tissue. A total of 270 POFs were diagnosed during the study period. A higher frequency was observed in females (71.9%) between the third (22.9%) and fourth (23.3%) decades of life. The anterior upper gingiva (29.1%) was the most affected region. Mature (86.7%) and immature (52.6%) bone tissue were the most frequent. There was a significant association between immature bone deposition and lesions with size ? 1.7 cm (p = 0.041); immature bone and cement-like tissue deposition with an evolution time ? 16 months (p < 0.001); deposition of immature bone and mesenchymal hypercellularization (p < 0.001); deposition of dystrophic calcification and the presence of ulceration (p < 0.001). The clinical characteristics corroborate the findings in the literature. The heterogeneous distribution and quantity of mineralized tissues found in the analyzed cases support the theory that the different mineralized tissues constitute a spectrum of clinical maturation of POF.
- Significance of immunohistochemistry biomarkers in prediction of malignant transformation of oral lichen planus:a systematic review(2022) Al-Jamaei, Aisha A H; Subramanyam, R V; Helder, Marco N; Forouzanfar, Tymour; Ruslin, Mohammad; van der Meij, Erik H.; de Visscher, Jan-GamOral lichen planus (OLP) is a chronic inflammatory disorder with increased risk for malignant transformation. Biomarker validation is a pivotal step in moving newly discovered biomarkers towards clinical implementation. We performed a systematic review of studies on biomarkers related to OLP, wherein biomarkers have been described in at least two independent studies. Our aim was to determine whether any of these biomarkers might be promising in predicting the increased risk of malignant transformation of OLP. We searched the following databases until August 2021: PUBMED, EMBASE, and Web of Science. Due to high heterogeneity, a qualitative rather than quantitative assessment was conducted. Only proteins that consistently showed a significantly high level of expression in neoplastic tissues versus OLP in two or more publications were considered as promising markers. Initial database researches identified 1671, of which 24 articles were included in the final analysis. The most frequently reported proteins were p53, Bcl-2 and Ki-67, though there were controversies. PCNA and P21 were the only proteins that showed consistent evidence of clinical usefulness as cancer predictors to be considered as promising markers. Extensive methodological variations in the evaluation of expressions and statistical analyses of the included markers were observed, which hampered comparisons of the results. Multiple levels of heterogeneity with a scarcity of high-quality studies were identified. PCNA and P21 were identified as promising predictive markers for evaluating the risk of malignant transformation of OLP, but they require further validation. The focus of future research on validation of predictive biomarkers of OLP should be considered as a high priority because it will accelerate the introduction of newly discovered markers into the clinical setting.
- Erythromycin:an alternative for the management of oral mucositis?(2022) Teixeira, Dieni-da Silveira; Louzeiro, Gabriel Campos; de Figueiredo, Maria-Antonia-Zancanaro; Cherubini, Karen; Salum, Fernanda-GonçalvesOral mucositis (OM) is an important acute adverse effect of anticancer therapy. This condition presents high morbidity and may lead to the suspension of anticancer therapy. We reviewed the literature on the pathobiology of OM and the properties of erythromycin (EM), to consider the possibility of its use for the prevention and treatment of OM. We searched the PubMed, Scopus and Web of Science databases and selected complete articles published in English or Spanish that met the inclusion criteria. The search terms ?erythromycin?, ?inflammation?, ?immunomodulation? and ?oral mucositis? were used. The control of free radicals, transcription factors and pro-inflammatory cytokines has been considered as the key to the management of OM. EM has the ability to modulate oxidative stress, acts on the transcriptional system and inhibits the production of several cytokines that have been directly implicated in OM pathobiology. The present review suggests that EM could be effective in the treatment of OM. Experimental studies investigating the use of EM in OM should be encouraged.
- Bone regeneration at extraction sockets filled with leukocyte-platelet-rich fibrin:an experimental pre-clinical study(2022) Park, Gene; Benalcázar-Jalkh, Ernesto B; Boczar, Daniel; Bergamo, Edmara Tp; Kim, Heoijin; Kurgansky, Gregory; Torroni, Andrea; Gil, Luiz; Bonfante, Estevam A.; Coelho, Paulo G.; Witek, LukaszWe aimed to histomorphometrically evaluate the effects of Leucocyte-Platelet-Rich Fibrin (L-PRF), with and without the combination of a bone grafting material, for alveolar ridge preservation using an in vivo canine model. Seven dogs (Female Beagles, ~18-month-old) were acquired for the study. L-PRF was prepared from each individual animal by drawing venous blood and spinning them through a centrifuge at 408 RCF-clot (IntrasSpin, Intra-Lock, Boca Raton, FL). L-PRF membranes were obtained from XPression fabrication kit (Biohorizons Implant Systems, Inc., AL, USA). A split mouth approach was adopted with the first molar mesial and distal socket defects treated in an interpolated fashion of the following study groups: 1) Empty socket (negative control); 2) OSS filled defect 3) L-PRF membrane; and 4) Mix of Bio-Oss® with L-PRF. After six weeks, samples were harvested, histologically processed, and evaluated for bone area fraction occupancy (BAFO), vertical/horizontal ridge dimensions (VRD and HRD, respectively), and area of coronal soft tissue infiltration. BAFO was statistically lower for the control group in comparison to all treatment groups. Defects treated with Bio-Oss® were not statistically different then defects treated solely with L-PRF. Collapsed across all groups, L-PRF exhibited higher degrees of BAFO than groups without L-PRF. Defects filled with Bio-Oss® and Bio-Oss® with L-PRF demonstrated greater maintenance of VRD relative to the control group. Collapsed across all groups, Bio-Oss® maintained the VRD and resulted in less area of coronal soft tissue infiltration compared to the empty defect. Soft tissue infiltration observed at the coronal area was not statistically different among defects filled with L-PRF, Bio-Oss®, and Bio-Oss® with L-PRF. Inclusion of L-PRF to particulate xenograft did not promote additional bone heading at 6 weeks in vivo. However, we noted that L-PRF alone promoted alveolar socket regeneration to levels comparable to particulate xenografts, suggesting its potential utilization for socket preservation.
- Facts and controversies regarding oral health in Parkinson's disease: A case-control study in Spanish patients(2022) García-De-La-Fuente, A. M.; Lafuente Ibáñez de Mendoza, Irene; Lartitegui-Sebastián, MJ.; Marichalar-Mendia, X.; Echebarria-Goikouria, MÁ.; Aguirre-Urizar, JM.Parkinson's disease (PD) is one of the leading neurological disorders, affecting more than 6 million people worldwide. These patients present motor and non-motor symptoms, including oral pathology. The objective of this research is to determine the oral health of patients diagnosed with PD, in order to stablish a specific preventive oral health programme.
