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Language Medicina oral, patología oral y cirugía bucal. Ed inglesa. 2025. Vol. 30, no. 05
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- De-epithelialized free gingival graft versus subepithelial connective tissue graft in the treatment of gingival recession: a systematic review and meta-analysis(2025) Tejedo, Joyce Rebeca Ignacio; Jara, Rebeca Alexandra Cruzado; Caceres, Lorena Zegarra; Vergara Buenaventura, Andrea; Muniz, Francisco Wilker Mustafa Gomes; Faveri, Marcelo; Meza-Mauricio, JonathanThe best technique to harvest gingival graft to treat gingival recessions (GR) remains a topic of ongoing debate. This systematic review aimed to evaluate the effect of de-epithelialized free gingival graft (DFGG) compared to subepithelial connective tissue graft (SCTG) in the treatment of GR Miller Class I and II or Cairo type I. Five databases were searched up to June 2024 to include randomized clinical trials (RCTs) comparing the clinical effects of DFGG with SCTG in the treatment of GR. The random effects model of mean differences was used to determine GR, and gain in keratinized tissue width (KTW), gingival thickness (GT) and clinical attachment level (CAL). The risk ratio was used to complete root coverage (CRC) at 6 and 12 months. Five RCTs including 183 and 111 GR at 6 and 12 months were included in this systematic review. The meta-analysis showed no statistically significant difference in GR reduction, gain in KTW, GT, CRC or CAL between groups at 6 and 12 months. At 12 months, the clinical results of DFGG were similar to those of SCTG in the treatment of GR.
- Periodontitis associated with prostate cancer and other urological cancers in patients over 50 years of age: a cross-sectional study(2025) Ajalcriña-Martensen, Andrea Alexandra; Minchón, Carlos Alberto; Astigueta-Perez, Juan; Gamboa-Vicente, Willy Gustavo; Ganoza-Larrea, Luis Jason; Asmat Abanto, Angel StevenPeriodontitis triggers systemic inflammatory reactions that may be associated with different oncological diseases, such as prostate cancer (PC), although little information exists on the possibility of this association. To determine whether periodontitis is associated with PC and other non-metastatic urological cancers in patients over 50. This cross-sectional study was conducted between August and September 2024 at the outpatient clinic of the Belén de Trujillo Hospital (HBT) and the Regional Institute of Neoplastic Diseases “Dr. Luis Pinillos Ganoza” - IREN Norte (IREN), in Trujillo, Peru. In total, 192 patients were evaluated: 64 with PC, 64 with non-prostatic urological cancer (NPUC), and 64 with non-oncological urological disease (NOUD). Reliability was determined through inter- and intra-evaluator calibration to diagnose periodontitis, gingivitis inflammation, and plaque control. The corresponding specialist physician diagnosed PC, NPUC, and NOUD. Statistical analysis was performed using the Chi-square and Kruskal-Wallis tests, including nonparametric multiple comparison tests, with a significance level of p<0.05. An association between periodontitis and PC was found in patients over 50. PC was also directly associated with moderate periodontitis (p=0.014) and generalized gingivitis inflammation (p=0.019). Concerning NPUC, an association was found with periodontal pockets of 3.5 - 5.5 mm (p=0.031) and last visit to the dentist more than one year ago (p=0.012). There was an association between periodontitis and PC in patients over 50. Patients with moderate periodontitis and generalized GI were more likely to present PC compared with patients with NOUD. In addition, there was a greater probability of presenting PC versus NPUC in patients with periodontal pockets of 3.5-5.5 mm and in those whose last visit to the dentist was more than one year ago.
- Changes in the periodontal and tomographic parameters of 36 anterior maxillary teeth one year after periapical surgery with submarginal incision(2025) Boronat López, Araceli; Cervera Ballester, Juan; Bernabeu Mira, Juan Carlos; Peñarrocha Diago, Miguel; Peñarrocha Oltra, DavidA study was made of the clinical periodontal changes and buccal cortical bone modifications using cone-beam computed tomography (CBCT) in anterior maxillary teeth with chronic apical periodontitis one year after periapical surgery with submarginal incision. A prospective case series analysis was made of anterior teeth subjected to apical surgery and submarginal incision with a follow-up period of 12 months. Clinical periodontal parameters were recorded, along with tomographic measurements of the buccal cortical bone and volume of the lesion (in mm3) before and one year after surgery. Success was assessed based on the clinical and tomographic data. Thirty-six anterior maxillary teeth from 36 patients with a mean age 43.1 years were enrolled in the study. One year after surgery, mean gingival recession was found to be 0.19 mm with a clinical attachment loss of 0.28 mm. Marginal bone loss was 0.25 mm. The thickness of the buccal cortical bone decreased at all three measurement points, with the greatest decrease being observed at 3 mm from the bone crest (0.58 mm). The distance from the apex to the buccal cortical bone (depth of the apex) decreased 0.59 mm at one year. The clinical parameters (clinical attachment level and probing depth) were not correlated with the tomographic measurements (cementoenamel junction-bone crest distance). The mean lesion volume was 457 mm3 at baseline versus 28.4 mm3 one year after surgery, representing a decrease of 93.8% in 12 months. The success rate at one year postsurgery was 94.4%. One year after apical surgery of anterior maxillary teeth with submarginal incision, only minimal clinical periodontal and tomographic changes are observed, with no clinical relevance. The mean lesion volume decreased 93.8%, and the success rate was 94.4%.
- Suppurative Stomatitis [Cheilitis Glandularis]: an underreported entity(2025) Panico, Juan Cruz Romero; Andrade, Bruno Augusto Benevenuto de; Lazos, Jerónimo; Martin, Rocío; Piemonte, Eduardo; Lopes, Caio Almeida Moreira; Freire, Clara Herrera; Panico, René Luis; Guilligan, GerardoStomatitis and Cheilitis Glandularis are inflammatory conditions of the minor salivary glands with uncertain aetiology, uncommon in clinical practice. Local factors and systemic comorbidities associated with hyposalivation could contribute to the onset of the disease. The aim of this study is to describe retrospectively a case series of Stomatitis and Cheilitis Glandularis from two Oral Medicine and Pathology Departments. Also, a review of the clinical and epidemiological variables and a discussion of the diagnostic criteria is presented. There were included cases of Stomatitis and Cheilitis Glandularis from two Oral Diagnosis Centres from Argentina and Brazil, according to Reiter et al criteria. Demographic and clinicopathological features were described. A concise review of current literature was performed discussing diagnostic criteria and possible etiological factors. There were included six cases sequentially retrieved from the last ten years. The patients included were 4 men and 2 women with an average age of 65.33 years old. The majority of the included cases showed comorbidities or were treated with drugs associated with hyposalivation or a decrease in salivary flow. Clinically, firm nodules and pus discharge was observed in minor salivary glands. Actinic damage was a poorly associated factor in this series. Histopathology revealed sialoadenitis, oncocytic metaplasia with different degrees of periductal inflammation in all cases. Stomatitis and Cheilitis Glandularis are challenging disorders of the oral cavity. Hyposalivation could be an early phenomenon in a multifactorial context. More studies are needed for a better understanding of these conditions.
- Butyrate enhances recovery of chemotherapy-induced oral mucositis by enhancing tight junction protein expression and inhibiting inflammatory responses(2025) Zeng, Jing-jing; Tan, Zeng-lin; Zhang, Ke; Han, Qian-nian; Ou, Shi-ning; Wang, Ze-kai; Liu, Jian-wei; Wang, Fang-yan; Huang, Ying-peng; Wu, Lin-fengChemotherapy-induced oral mucositis (OM) is a common complication of cancer treatment that significantly impacts patients' quality of life. Butyrate, a short-chain fatty acid, has been shown to inhibit inflammation and mitigate intestinal mucosal damage. How, its effect in treating OM remains unclear. OM model in mice pretreated with 5-FU solution was established by injecting 20% acetic acid into oral mucosa. Sodium butyrate was given for treatment. H&E staining was used to observe histopathological changes, and qRT-PCR to assess inflammatory factor level changes in ulcer tissues after treatment. Also, qRT-PCR and immunofluorescence staining were used to evaluate the expression and distribution of tight junction protein in ulcer tissues. Sodium butyrate treatment improved the weight loss in mice caused by OM and promoted the repair of oral mucosa in a time-dependent manner. In addition, sodium butyrate significantly inhibited the mRNA levels of inflammatory factors such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and interleukin-18 (IL-18) in the ulcer tissue. Moreover, sodium butyrate promoted the mRNA and protein expressions of tight junction protein-1 (ZO-1) and Claudin-1 in the epithelial cells of the ulcer tissue. Butyrate promotes OM healing by reducing inflammation and increasing the expression of tight junction proteins in ulcer tissues.
- Current perspectives on the training of Oral Pathology specialists in Brazil: a cross-sectional study(2025) Ferreira, Luiz Miguel; Trezena, Samuel; Nascimento, João Pedro Santos; Maia-Lima, Marcos Paulo; Bonan, Paulo Rogério; Pego, Sabina Pena Borges; Martelli Júnior, HercílioOral Pathology (OP) is an important part of diagnosing and managing oral and maxillofacial diseases. Despite being recognized as a specialty in Brazil for over 50 years, significant gaps remain in the availability of specialists and training programs. Therefore, this study aims to map and analyze the training of specialists in OP in Brazil. A cross-sectional study was conducted using publicly available data from Brazilian governmental databases, including the Federal Council of Dentistry, the Brazilian Institute of Geography and Statistics, and the Ministry of Education. Variables analyzed included the number of OP specialists, their geographic distribution, training opportunities, and population coverage. Descriptive and comparative analyses were performed using Microsoft® Excel (version 2410) and Statistical Package for Social Sciences® (version 27.0). In 2024, 424 active OP specialists were registered in Brazil, composed of 240 women and 184 men, representing only 0.3% of all dental specialists. The ratio of OP specialists to inhabitants was 1:478,964, with marked regional disparities. The Southeast had the highest density, while the North had the lowest, with some states lacking any OP specialists. Additionally, 12 active OP training programs were identified, primarily concentrated in the Southeast. Most programs were distance learning, limiting opportunities for practical training. Temporal analysis revealed a decline in OP specialist registrations over the past two decades, despite population growth. Brazil faces challenges in OP training, including insufficient specialists, uneven regional distribution and limited hands-on training opportunities. The expansion of hybrid training models and the promotion of the OP specialty among dental students are vital to address these issues. Collaborative efforts between educational institutions, professional organizations, and the government are essential to strengthen the specialty and improve early diagnosis rates of oral cancer.
- Evaluation of the incidence of obstructive sleep apnea in mandibular fracture patients before and after treatment with the STOP-BANG questionnaire(2025) Jafari, Mahdi; Samieirad, Sahand; Goharian, Rozhin Kafshdar; Grillo, RicardoMandibular fractures are common injuries, leading to various complications, including obstructive sleep apnea (OSA). The aim of this study was to evaluate the occurrence of OSA in relation to mandibular fracture type before and after treatment using the STOP-BANG questionnaire. This prospective study was conducted on patients admitted to Shahid Kamyab Hospital from 2022 to 2023 with mandibular fractures. Patients were classified based on the type and location of fracture, age, gender, and cause. The primary predictor variable was the type of mandibular fracture. The primary outcome variable was the occurrence of OSA as measured by the STOP-BANG questionnaire. Secondary outcomes included changes in STOP-BANG scores over time before and after treatment. Covariates were divided into age and gender (demographic), type of surgical treatment, and Body Mass Index (physiologic). Data analyses included comparisons of STOP-BANG scores over multiple time points (pre-fracture [T0], post-fracture [T1], 1 week post-surgery [T2], and 1 month post-surgery [T3]). The results were analyzed using SPSS 16 software, with a significance level set at p-value < 0.05. In this study, 154 patients were examined. Ninety-five patients had unilateral fractures and 59 patients had bilateral fractures. The study groups were homogeneous in terms of age, gender, surgical method, and Body Mass Index (BMI). In both unilateral and bilateral groups, the average STOP-BANG score changed significantly over time (p<0.001). Pairwise comparisons indicated that the STOP-BANG score significantly increased at all times compared to pre-fracture, but decreased significantly at each subsequent time point after the fracture. The mean STOP-BANG score was significantly higher in the bilateral group compared to the unilateral group at each time point (T1, T2, T3) (p<0.001). The mean changes in STOP-BANG score relative to T0 were significantly greater in the bilateral group compared to the unilateral group (p<0.001). Mandibular fractures affect respiratory conditions and can lead to OSA. Surgeons should consider the reduction in respiratory space when treating these patients and choose an appropriate treatment plan. Bilateral fractures are more likely to lead to OSA, whereas OSA occurrence was rarely observed in cases of unilateral fractures.
- Expression of regulatory and executor proteins of apoptosis in odontogenic keratocyst: a systematic review(2025) Martínez-Flores, René; Muñoz-Orrego, Matías; Marín-Márquez, Constanza; Schuch, Lauren F.; Silveira, Felipe Martins; Bologna Molina, Ronell; Niklander, SvenThe odontogenic keratocyst (OKC) corresponds to the third most common odontogenic cyst of the maxillary bones, originating from the dental lamina or its remnants. Apoptosis dysregulation, due to an imbalance between anti-apoptotic and proapoptotic proteins, has been proposed as a promoter for the development and progression of OKC. This study aimed to conduct a systematic review to synthesize the current knowledge on effector proteins of the intrinsic and extrinsic pathways, and executor proteins of apoptosis in OKC and compare their expression to other odontogenic cysts and tumors. Primary studies were searched in PubMed, Scopus, and Web of Science databases, following the recommendations of PRISMA. Inclusion criteria were articles in English reporting the expression of at least two apoptosis-related proteins in OKC, studies using human tissues, descriptive retrospective case series, or in vitro assays. Seven articles met the inclusion criteria and were considered for data extraction and analysis. Of the selected articles, six studied proteins related to the regulation of the intrinsic pathway of apoptosis, all reporting the immunohistochemical expression of Bcl-2 and BAX. Only one study reported the immunohistochemical expression of proteins related to the regulation of the extrinsic pathway, specifically Fas and FasL. Regarding apoptosis execution proteins, only one article characterized the immunohistochemical expression of caspases, specifically caspase-3. OKC expresses proteins related to apoptosis regulation similar to other aggressive odontogenic lesions, such as ameloblastoma. This suggests that apoptosis dysregulation may be essential in its development and progression.
- Cluster and correspondence analyses for oral ulcer activity related factors in Behçet’s syndrome(2025) Polat-Akmansoy, Berceste; Aksoy, Burcu; Şişman-Kitapçı, Nur; Akmansoy, Şükrü Can; Çandereli, Zehra Özge; Sarı, Fatma Büşra; Sacoor, Sarah; Gokani, Bindi; Bibi, Azimoon; Adesanya, Adebowale; Desai, Pareen; Senusi, Amal A.; Karacayli, Umit; Alibaz-Öner, Fatma; İnanç, Nevsun; Ergun, Tulin; Yay, Meral; Fortune, Farida; Direskeneli, Haner; Mumcu, GoncaBehçet’s Syndrome (BS) is a multisystemic vasculitis characterized by a heterogeneous clinical profile, including mucocutaneous, musculoskeletal, neurological, ocular, vascular and gastrointestinal manifestations. BS patients often experience a continuous, low-level disease activity state due to persistent oral ulcers. This study aimed to define relations among oral ulcer activity (OUA), gender and treatments through K-Means Cluster and Correspondence Analyses (CA) in patients with BS. In this cross-sectional study, 526 BS patients from two tertiary centres in Turkey and the United Kingdom were included. The K-Means Cluster Analysis was performed to identify homogeneous clinical profiles for OUA by combining the disease severity score reflecting organ involvement and the number of oral ulcers. Then, CA was performed to visualize associations between gender and medications (non-immunosuppressive: non-IS vs. IS) in clusters. K-Means Analysis identified three clusters regarding mucocutaneous and major organ involvement and cluster regarding with major organ involvement. Clusters were named according to OUA and the disease severity.The number of oral ulcers was found to be similar in the “Low OUA” cluster (n=202, 65.03%; 2.18±1.13) and the “Low OUA with Major Organ Involvement” cluster (n=63, 19.25%; 2.19±1.37) (p=0.368). These were lower than those in the “Moderate OUA” Cluster (n=30, 9.8%; 7.60±1.88) and the “High OUA” cluster (n=11, 3.59%; 14.91±2.34) (p<0.001).CA visualized that non-ISs in “Low OUA” cluster, ISs in “Low OUA with Major Organ” cluster for both genders as well as male patients treated with non-ISs or ISs in “Moderate OUA” cluster were predominant groups. The presence of two oral ulcers might be accepted as the cut-off value for low OUA. Moreover, intensive treatment protocols must be provided for elevated oral ulcer activity in male patients who were treated with non-IS medications in BS.
- Clinicopathological profile of subgemmal neurogenous plaques: a 52-year retrospective study of 22 cases(2025) Sousa, Julliany Taverny; Morais, Hannah Gil de Farias; Colares, Débora Frota; Dantas da Silveira, Ericka Janine; Freitas, Roseana A.; Queiroz, Lélia-Maria-Guedes; Souza, Lélia Batista deThis study describes the clinical and histopathological profile of 22 subgemmal neurogenous plaques (SNP) through a 52-year retrospective study conducted at an Oral Pathology referral center in the Northeast of Brazil. Clinical data (age, biological sex, symptoms, clinical presentation, lesion size, duration at diagnosis, growth rate, implantation, and consistency) were retrieved from biopsy records. Hematoxylin and eosin-stained slides from all selected cases were re-evaluated. SNPs accounted for 0.12% (n = 22) of all lesions diagnosed at the center. A predominance among female patients was observed (n = 20; 90.9%), with most diagnoses occurring in the fifth to sixth decades of life (mean 57.5 ± 12.19 years). Clinically, the lesions typically presented as slow-growing but painful, reddish papules. Five cases were associated with oral lymphoepithelial cysts. Histologically, common features included spindle cells, subepithelial nerve plexuses, ganglion cells, mast cells, lymphoid tissue, and germinal centers. These findings underscore the importance of recognizing the clinical and histopathological characteristics of SNPs to avoid misdiagnosis as neural tumors.
- Artificial intelligence in maxillofacial trauma: expert ally or unreliable assistant?(2025) Agbulut, Nelli; Unlu, MericLarge language models (LLMs), such as ChatGPT, have demonstrated potential in synthesizing complex clinical information, yet concerns persist regarding their accuracy and reliability in specialized domains. The rationale of this study is to address a gap in the literature by evaluating ChatGPT-4o’s capabilities and limitations in terms of accuracy and reliability on oral and maxillofacial traumatology. A total of 188 oral and maxillofacial trauma-related questions were selected from a comprehensive resource. Thirty questions were randomly chosen and submitted to ChatGPT-4o resetting to “new chat” mode every repetition to eliminate potential memory bias. Accuracy was scored using a 3-point Likert scale. Reliability was assessed with weighted kappa (κ) and Intraclass Correlation Coefficient (ICC), and internal consistency was evaluated using both Cronbach's alpha (α) and McDonald’s omega (ω). The accuracy rates for comprehensive and adequate responses were calculated as 38% (95% CI: 32.5% - 43.5%) and 58% (95% CI: 52.1% - 63.3%), respectively. Weighted kappa (κ = 0.469) and ICC (0.503) indicated moderate reliability. Internal consistency metrics revealed excellent and good reliability, respectively (α = 0.904, ω = 0.860). ChatGPT-4o demonstrated promising results as an adjunct tool in providing supplementary educational content, verifying critical information, and supporting the decision-making processes in oral and maxillofacial traumatology. Current limitations warrant further research. Future enhancements in LLMs and prompt engineering may assist in the optimization of their clinical applicability and alignment with evidence-based standards.
- Factors influencing intraoperative blood loss in bimaxillary orthognathic surgery(2025) Topan, Cihan; Demirbas, Ahmet E.; Dogruel, Fatma; Ümit, Kadir Kaan; Yaşlı, Seher Orbay; Soylu, Emrah; Gunay Canpolat, DilekThe study aimed to investigate the risk factors that could affect intraoperative blood loss in patients who underwent orthognathic surgery. The study included a retrospective analysis of 400 patients who underwent bimaxillary orthognathic surgery. Data on demographic, surgical, and hematological parameters affecting intraoperative blood loss were statistically analyzed. The mean intraoperative blood loss of male patients was statistically higher than that of female patients (p ≤ 0.001). The mean blood loss was higher in patients aged 25 years and older than in patients aged 17-24 (p=0.004). Patient weight and duration of surgery were positively correlated with the amount of intraoperative bleeding (r = 0.280 and r = 0.371). Platelet (PLT) count negatively correlated with blood loss (r=-0.213). The MPV/PLT ratio and hemoglobin (HGB) levels were positively correlated with bleeding (r=0.208 and r=0.110). In orthognathic surgeries, factors such as age, gender, body mass, and duration of surgery were found to be associated with intraoperative blood loss. Males, patients over 24, overweight patients, and prolonged surgical procedures are all significant risk factors for bleeding. In addition, high HGB levels, low platelet count, and low MPV/PLT ratios are also associated with an increased risk of blood loss.
- Metastatic melanoma of the major salivary glands: a systematic review(2025) Rizzardi, Pedro Henrique; de Farias Gabriel, Amanda; Martins, Isabela Domingues; Carrard, Vinicius C.; Zanella, Virgilio Gonzales; Girardi, Fábio Muradás; Martins, Marco Antonio T.; Wagner, Vivian Petersen; Martins, Manoela D.; Schuch, Lauren F.Metastatic melanoma of the major salivary gland has been rarely reported in the literature. Thus, the aim of this study was to integrate all data about the clinical, sociodemographic, histopathological, treatment, and follow-up characteristics of metastatic melanoma of the major salivary glands. Electronic searches were performed in five databases and the grey literature according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020. Case reports or case series describing metastatic melanoma of the major salivary gland without language or year of publication restriction were included. Twenty-five studies reporting 47 cases of metastatic melanoma were identified. The mean patient age at diagnosis was 56.321.5 years, mainly occurring in men (70.2%). The site of the primary melanoma was mostly in the head and neck region (65%) and the parotid (93.6%) was the most affected major salivary gland by metastatic lesions. Parotidectomy was the main treatment choice. The overall 1- and 5-year survival rates were 79% and 45%, respectively. Metastatic melanoma of the major salivary gland is an uncommon phenomenon involving a poor prognosis.
- Oral leukoplakia: still an enigmatic disorder(2025) Aguirre Urizar, José ManuelOral leukoplakia is the most frequent and representative potentially malignant disorder of what is known as oral precancer. Since the first descriptions, this pathology, which initially seems simple, has been the subject of controversy and discussion, and it still maintains multiple unknowns and enigmas to be solved. A narrative and integrative review of the epidemiological, pathogenetic, diagnostic, prognostic and therapeutic aspects of this important oral disorder has been carried out. Oral leukoplakia still presents multiple enigmas regarding its actual epidemiology, its multifactorial and multistage pathogenesis, its definition and diagnosis, its malignant development and its treatment. We must conduct well-designed prospective studies on this fascinating oral pathology, on well-diagnosed clinical cases with clinicopathological criteria agreed and accepted by the scientific community. Only in this way will we be able to clarify the enigmas it still presents.
- Suppurative infections after lower third molar surgery: a systematic review(2025) Pippi, Roberto; Giuliani, UmbertoAfter lower third molar surgery, suppurative infections can occur. They can spread into adjacent tissues, toward superficial mucosal or skin planes or toward deep facial and neck fascial spaces. The 2020 PRISMA guidelines for systematic reviews were followed. A literature search was conducted, without initial time limit, in the Medline database, via Pubmed (MEDLINE), and SCOPUS. For the analysis of statistical significance, the hypothesis test on the difference between means with unknown variances was used. Eleven articles met the inclusion criteria. The total number of extractions taken from the articles included in the review is 7363, with a 5.35% total incidence of purulent infections. The incidence of purulent infections was found significantly higher in cases in which antibiotic prophylaxis was not performed. Although lower third molar extraction is the most frequently performed oral surgical procedure, little has been written about post-operative purulent infections, in relation to risk factors, involved spaces, and performed therapies, so to be able to identify preventive and therapeutic behaviors based on scientific evidence. Antibiotic prophylaxis is the only variable which resulted in determining a significative statistical reduction in the incidence of purulent infection after lower third molar surgery.
- Clinical characteristics of simple bone cyst associated within florid cemento-osseous dysplasia: a meta-analysis(2025) Rave, Léonie; Rollin, Marie; Porporatti, André Luís; Taihi, IhsèneThe objectives of this study were to better understand the association between simple bone cysts (SBC) diagnosed within florid cemento-osseous dysplasia (FCOD) by systematically reviewing the literature with a meta-analysis. This review allows us to study the epidemiology, characteristics, treatments, and follow-up of the association between these two entities. A systematic review was performed on PubMed, Scopus, Cochrane library, Embase and Google Scholar. Articles reporting primary studies, case reports and case series were included. We reviewed all articles between 1976 and November 2024. Recorded data were patient’s characteristics, clinical and radiological features, diagnosis, treatment, and follow-up. The meta-analysis was performed for the prevalence of the localization of SBC associated FCOD and the number of SBC lesions within FCOD. A total of 615 studies were assessed for eligibility by reading titles and abstracts. Finally, 16 articles were included, with 51 patients presenting SBC associated with FCOD. Patients were mostly women (92%) with most of an African origin (81,25% ). The mean age was 41-year-old. The usual treatment for the cyst was surgical exploration with bleeding stimulation to improve healing. After surgical procedure, a majority of the followed-up cases healed completely (52%) or partially (32%). Eight cases reported a recurrence during the mean follow-up period of 6,6 years. SBC and FCOD are two conditions which can be rarely associated. This may be under-diagnosed as SBC can be misdiagnosed as part of the FCOD lesions. This review highlights the similar clinical characteristics to FCOD which makes important to find out more clinical and radiographic diagnosis criteria to better diagnose and provide the adequate treatment to obtain bone healing.
- Investigation of the stresses on pterygoid and zygomatic implants used in atrophic maxilla rehabilitation by finite element analysis(2025) Bakay, Ufuk; Gulsun, Belgin; Guler, RidvanThis study aims to compare stresses from vertical and oblique forces on pterygoid and zygomatic implants, combined with dental implants, in a atrophic maxilla using finite element stress analysis. A computed tomography scan was used to create a geometric model of a completely edentulous adult maxilla. The maxillary bone was scanned using cone beam computed tomography (ILUMA, Orthocad, CBCT, 3M Imtec, Oklahoma, USA), and the obtained sections were transferred to the 3D-Doctor (Able Software Corp., MA, USA) software. Two models were created in the study. In the first model, zygomatic and dental implants were used, while in the second model, pterygoid and dental implants were used. A 150 N vertical force and a 100 N oblique force at a 30-degree buccolingual angle were applied. With finite element analysis assessed stress distribution in the implants and peri-implant bone tissue. When the obtained stress data were examined, under vertical forces, the maximum stress on the implants was higher in Model 1 (151.984 MPa) compared to Model 2 (151.773 MPa), but no significant difference was observed. The stress formed in the metal substructure was higher in Model 2 (422.042 MPa) compared to Model 1 (308.376 MPa). The maximum principal stress in the alveolar bone was greater in Model 2 (46.866 MPa) compared to Model 1 (15.719 MPa), and the minimum principal stress in the alveolar bone was also greater in Model 2 (80.360 MPa) compared to Model 1 (76.310 MPa). Under oblique forces, the average stress on the implants was higher in Model 2 (128.297 MPa) than in Model 1 (79.607 MPa). When the stresses occurring on zygomatic and pterygoid implants and the alveolar bone surrounding these implants were compared, it was observed that the use of zygomatic implants was more beneficial in reducing both dental and biomechanical stress.
- Dental treatment approaches under general anesthesia in children with cancer(2025) Kızılcı, Esra; Kolçakoğlu, Kevser; Yücel, Gül; Kepezkaya, MerveTo evaluate dental treatment approaches under general anesthesia in children with cancer. DMF-T values of existing decay, missing and filled teeth of 68 pediatric patients receiving active cancer treatment were recorded. Systemic and physical examinations of patients were performed by a paediatrician. İntraoral and extraoral examinations of children were performed by pediatric dentists. The dental treatment plan encompasses the child's individualized oral health needs. Dental procedures are generally performed in the controlled environment of a hospital operating room under general anaesthesia. Analyzes were made with SPSS 25.0 package program. The study determined that the average age was 6.47±2.93. In this study, extraction-focused treatments were used instead of restorative (r=0.346, p=0.01) and endodontic treatments (r=0.274, p=0.01). Despite the development of restorative and endodontic treatments under general anaesthesia, even pediatric crown applications, radical decisions must be made to control the medical condition of patients with childhood cancers.
