Medicina oral, patología oral y cirugía bucal. Ed inglesa. 2010. Vol. 15, no. 2

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    Polyurethane and PTFE membranes for guided bone regeneration : histopathological and ultrastructural evaluation
    (2010) Monteiro, Adriana Socorro Ferreira; Macedo, Luís Guilherme Scavone; Macedo, Nelson Luiz; Balducci, Ivan
    Objective: The purpose of this study was to research a membrane material for use in guided bone regeneration. Study design: In this study, 25 male Wistar rats were used to analyze the biocompatibility and degradation process of biomembranes. The morphological changes in subcutaneous implantations were assessed after 7, 14, 21, 28 and 70 days. The materials were made of polyurethane polymer (AUG) obtained from vegetal oil (Ricinus communis) and polytetrafluoroethylene membrane (PTFE). The surface characteristics of the physical barriers in scanning electronic microscopic (SEM) were also evaluated. Results: In both groups, the initial histological analysis showed moderate inflammatory infiltrate, which was predominantly polymorphonuclear. There was also a presence of edema, which was gradually replaced by granulation tissue, culminating in a fibrous capsule. In the AUG group, some multinucleated giant cells were present in the contact interface, with the space previously occupied by the material. However, membrane degradation was not observed during the period studied. According to the present SEM findings, porosity was not detected in the AUG or PTFE membranes. Conclusion: The researched material is biocompatible and the degradation process is extremely slow or may not even occur at all.
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    Porous titanium for biomedical applications : an experimental study on rabbits
    (2010) Vasconcellos, Luana Marotta Reis de; Leite, Daniel de Oliveira; Nascimento, Fernanda Oliveira; Vasconcellos, Luis Gustavo Oliveira de; Graca, Mário Lima de Alencastro; Carvalho, Yasmin Rodarte; Cairo, Carlos Alberto Alves
    Objective: The aim of this study was to carry out an in vivo assessment of bone ingrowth in two different types of porous titanium -the first being completely porous, and the second with a porous surface and dense nucleus, manufactured by powder metallurgy- and to evaluate their mechanical properties. Study design: Ten scaffolds from each group were submitted to metallographic analysis and compression tests. Next, two scaffolds of each type were inserted into 14 rabbits, which were sacrificed 8 weeks after surgery. The samples were submitted for histological examination. Results: Metallographic analysis revealed interconnected pores, and the average interconnected pore diameter was about 360 mm, with 36% total porosity. The totally porous titanium samples and the titanium samples with porous surface and dense nucleus showed an average compressive strength of 16.19 MPa and 69.27 MPa, respectively. After 8 weeks, the animals showed bone ingrowth, even into the most internal pores. Conclusions: The pore morphology was effective in permitting bone ingrowth in both groups. Titanium scaffolds with a porous surface and dense nucleus showed the best mechanical properties and most adequate interface.
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    Simultaneous occurence of compound odontoma and arrested root formation as developmental disturbances after maxillofacial trauma : a case report
    (2010) Güngörmü?, Metin; Yolcu, Ümit; Aras, Hamdi; Halicio?lu, Koray
    Traumatic injury to a primary tooth and/or a bone fracture has the potential to damage the underlying permanent tooth germ which may disturb its development. The extent of the malformation depends on the developmental stage of the permanent tooth and the intensity of the trauma. The presence of infection may be a predictive factor for these abnormalities. Open surgical procedures can also potentially cause impaction and developmental disturbances. Several developmental alterations such as discolouration, hypoplasia, crown dilaceration, root angulation or dilaceration, sequestration of permanent tooth buds and disturbance in eruption have been reported in permanent teeth after trauma. However, odontoma-like malformations and partial or complete arrest of root formation are rare complications developed after trauma. This article presents a rare case with simultaneous occurrence of an odontoma-like malformation and complete and partial arrested root formations as the results of maxillofacial trauma. Almost all pediatric fractures must be managed with closed reduction as much as possible. However, if it is necessary to perform an open reduction, careful attention must be paid during placement of the osteosynthetic plates and screws; and tooth bud development must be followed periodically.
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    Relationship between preoperative anxiety and postoperative satisfaction in dental implant surgery with intravenous conscious sedation
    (2010) González Lemonnier, Sandra; Bovaira Forner, Maite; Peñarrocha Diago, María; Peñarrocha Oltra, David
    Purpose: To study if patient preoperative anxiety is related to age and gender and to compare preoperative anxiety with postoperative patient and surgeon satisfaction in dental implant surgery under intravenous conscious sedation. Materials and Methods: Dental implants were placed in 102 patients under local anesthesia and intravenous conscious sedation. The procedures were performed with or without dental extractions, and with or without bone regeneration. Anxiety was evaluated using Corah?s Dental Anxiety Scale and levels of surgeon and patient satisfaction were evaluated on an adapted scale. Results: Low preoperative anxiety was observed in 27.8% of patients, moderate in 50%, and high in 22.2%. Mean value of anxiety was 9.8+/-3.7. The level of surgeon satisfaction was adequate in 87.8% of the surgeries; patients were awake and nervous in 4.4% of surgeries, and excessively sleepy, with little cooperation in 7.8% of surgeries. Regarding patient satisfaction, the procedure was comfortable for 23.3% of patients, neither comfortable nor uncomfortable for 28.9%, a slightly uncomfortable experience for 36.7%, and very uncomfortable for 10% of patients. Younger patients and women were observed to have more anxiety, the difference being statistically significant. Patients with higher preoperative anxiety expressed a lower level of satisfaction, with statistically significant differences. There was no significant relationship between preoperative patient anxiety and postoperative surgeon satisfaction. Conclusion: Anxiety was higher in younger patients and women. In this study, a higher preoperative patient anxiety was associated with lower patient satisfaction, but had no influence on postoperative surgeon satisfaction.
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    Determinants of dental care utilization by the adult population in Buenos Aires
    (2010) Marín, Gustavo Horacio; Urdampilleta, Pablo; Zurriaga Llorens, Oscar
    Objective: To establish the frequency with which the general population is seen by a dentist and the variables associated with the lack of regular dental check-ups. Methods: A cross-sectional study with a descriptive and analytical phase conducted in an urban community in Argentina. A sample population was obtained by stratified method. Socioeconomic conditions (measure by UBN index), health, health coverage, level of education and location of the households with respect to the dental clinics were all taken into consideration in selecting the sample. We performed a uni-and multivariate analysis. The statistical software used was SPSS 9.0 for Windows and EpiInfo6 Version 6.0. Results: We observed significant associations between the lack of dental care and poverty levels, presence of UBN, living in the suburbs or at a remote distance from dental clinics, and the lack of health insurance. However, in a multiple regression analysis, only the geographical and socioeconomic characteristics of the respondents and their households had statistical significance. Conclusion: The section of the community that is less likely to visit their dentist regularly are those with higher socio-economic risk. Having health insurance or having a dental clinic close to home does not ensure more frequent check-ups. Given that, as demonstrated in this work, spontaneous demand for attention is extremely low, public policies should aim to include this vulnerable population in preventive and scheduled care.
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    Periodontal disease and oral hygiene benefits in HIV seropositive and AIDS patients
    (2010) Lemos, Silvinha S. S.; Oliveira, Flávia A.; Vencio, Eneida Franco
    Objectives: The frequency of gingival and periodontal disease in HIV-seropositive and AIDS patients was investigated in order to evaluate the oral hygiene benefits of using mechanical therapy. Study design: thirty-two consenting HIV-positive patients were examined. Their gingival and periodontal status were evaluated using the Gingival Index and the Simplified Oral Hygiene Index. The data were assessed at baseline, after three months and after six months. Subjects received mechanical therapy, which included calculus removal, scaling and root planning, tooth polishing and oral hygiene instructions. The maintenance of oral hygiene was performed weekly. HIV staging and CD4 counts were also investigated. Results: At the baseline, gingival and periodontal disease was present in 71.9% of all subjects. Chronic gingivitis (43.8%) was the most frequent in all subjects. A clear improvement in gingival health was registered in 78.2% of subjects after six months of mechanical therapy. No association was registered between CD4 count and gingival/periodontal status or attachment loss with HIV staging. Conclusions: Chronic gingivitis was the most frequent disease in HIV infected and AIDS patients. Oral hygiene using mechanical therapy improves the gingival condition, suggesting that it is an important step in the maintenance of periodontal health.
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    Effect of calcium hydroxide dressing on microleakage of composite restorations in endodontically treated teeth subsequent to bleaching
    (2010) Rahimi, Saeed; Shahi, Shahriar; Kimyai, Soodabeh; Khayyam, Lali; Abdolrahimi, Majid
    Objective: This study evaluates the effect of calcium hydroxide dressing on microleakage of composite restorations following non-vital bleaching. Methods: A total of 45 sound extracted human maxillary central incisors underwent endodontic treatment. The teeth were randomly divided into three groups (n=15). In group 1, access cavities were restored with composite. In group 2, the teeth underwent a bleaching procedure for one week before being restored with composite. In group 3, following a bleaching procedure, calcium hydroxide paste was placed in the pulp chamber for one week. The teeth were then restored with composite. The specimens were subjected to a dye leakage test. The data was analyzed using Kruskal-Wallis and Mann-Whitney U tests. Results: There were significant differences between the groups (P<0.0005). No statistically significant differences were found between groups 2 and 3, while the differences between other groups were significant. Conclusions: The bleaching agent increased microleakage of composite restorations in non-vital bleaching, whereas microleakage was not found to be increased by calcium hydroxide
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    Maxillary sinus septa : A systematic review
    (2010) Maestre Ferrín, Laura; Galán Gil, Sonica; Rubio Serrano, Minerva; Peñarrocha Diago, María; Peñarrocha Oltra, David
    This review analyzes articles published on the presence of septa in maxillary sinuses. An automated search was conducted on PubMed using different key words. This search resulted in 11 papers in which the presence of antral septa was assessed. These septa are barriers of cortical bone that arise from the floor or from the walls of the sinus and may even divide the sinus into two or more cavities. They may originate during maxillary development and tooth growth, in which case they are known as primary septa; or they may be acquired structures resulting from the pneumatization of maxillary sinus after tooth loss, in which case they are called secondary septa. Several methods have been used in their study, direct observation on dried skulls or during sinus lift procedures; and radiographic observation using panoramic radiographs or computed tomographs. Between 13 and 35.3% of maxillary sinuses have septa. They can be located in any region of the maxillary sinus and their size can vary between 2.5 and 12.7 mm in mean length. Some authors have reported a higher prevalence of septa in atrophic edentulous areas than in non-atrophic ones. If a sinus lift is conducted in the presence of maxillary sinus septa, it may be necessary to modify the design of the lateral window in order to avoid fracturing the septa.
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    Solitary fibrous tumor surrounding the carotid sheath
    (2010) Gómez Oliveira, G.; Álvarez Flores, Modesto; Arribas-García, Ignacio; Martínez Gimeno, Carlos
    Solitary fibrous tumors (SFTs) are rare spindle cell neoplasms that are mostly found arising from the pleura. Although SFTs recently have been reported in other regions, they are rare in the head and neck and have often been misdiagnosed due to their rarity. SFTs are benign in most cases. Clinically, SFTs usually manifest as wellcircumscribed, slow-growing, smooth and painless masses. Symptoms are often minimal, although they may include sore throat, difficulty in swallowing, change of voice or trismus. CT-Scan and MRI are the most sensitive imaging procedures used. The treatment of choice is complete surgical excision of the lesion. Because recurrences have been noted up to 30 years after surgery, long-term follow up is mandatory. In this article, we present a case of a Solitary Fibrous Tumor arising in the parapharyngeal space in a 20-year-old man, involving the carotid sheath, treated by surgical excision with no recurrence after 1 year. The clinical presentation, surgical management and pathological findings are described.
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    Tooth-Implant connection : a bibliographic review
    (2010) Hita Carrillo, Celso; Hernández Aliaga, Manuel; Calvo Guirado, José Luis
    The aim of this study was to carry out a bibliographic review of all available literature addressing the issue of whether or not the connection of teeth to implants by means of a prosthesis is a viable treatment alternative. Twenty articles from a variety of sources were analyzed and classified in order to draw conclusions. Articles were classified by type and an analysis was made of the different variables considered in each study, obtaining percentages of implant survival ranging from 84.4% to 100%, prosthetic complications ranging from 80% to 90%, and the incidence of dental intrusion ranging from 0 to 5.6%. Biomechanical studies: Some articles studied models in order to assess different connections subjected to force, in which varying results were obtained. Rigid connections appeared to produce the most stress to the natural tooth, periodontal ligament and peri-implant bone; non-rigid connections reduced the stress to the bone, but increased stress to the prosthesis. Clinical studies: The results obtained were disparate. Studies in the medium or short-term show this as a viable treatment alternative, whereas some studies point to a greater risk of complications, although the use of rigid connection decreases the percentage of intrusion. Other bibliographic reviews have concluded that there is a need for more longitudinal studies on the viability of tooth-implant connection, also concluding that complications are greater when this is the chosen treatment. As a viable alternative with an acceptable success rate, this course of treatment is always associated with rigid connection rather than non-rigid connection. Although intrusion is avoided with rigid connection, this nevertheless remains inadvisable as the primary treatment choice.
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    Atraumatic maxillary sinus elevation using threaded bone dilators for immediate implants. A three-year clinical study
    (2010) Calvo Guirado, José Luis; Gómez Moreno, Gerardo; López Marí, Laura; Ortiz Ruiz, Antonio José; Guardia Muñoz, Javier
    Objective: The aim of this study was to evaluate the efficacy of sinus floor elevation using sequential bone dilators. Materials and Methods: Thirty patients took part in the study (18 women and 12 men) with ages ranging between thirty-six and sixty-three years, selected according to inclusion and exclusion criteria, who showed a bone deficit in the upper posterior alveolar margin of 5-8 mm in height. Sixty expanded platform internal connection implants were placed with diameters of 4/5/4 mm and lengths varying between 10 (n=10) and 11.5 mm (n= 50). Results: Data obtained were analyzed using SPSS 15.0 software. The average intra-sinus bone gain with MP3 biomaterial of porcine origin was 4.13 +/- 0.97 SD mm at the moment of implant placement, 3.90 +/- 1.15 SD mm after twelve months, 3.74 +/- 1.05 SD mm after 24 months and 3.62 +/- 1.75 SD mm after 36 months. Two implants were lost at the moment of prosthesis placement. Conclusions: Alveolar lifting technique in the upper maxilla using bone dilators achieved a 96.6 % implant success rate after a three-year follow-up. Intra-sinus bone biomaterial remodeling was 0.51 +/- 0.08 mm from day zero to the thirty-six-month follow-up. This is a procedure that reduces the amount of surgery necessary and is of both aesthetic and functional benefit to the patient.
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    Maxillary sinus lift performed using ultrasound. Evaluation of 21 patients
    (2010) Sánchez Recio, Cristina; Peñarrocha Diago, María; Peñarrocha Diago, Miguel; Peñarrocha Oltra, David
    Purpose: The aim of the present study was to evaluate the sinus membrane perforations that occurred during a sinus lift procedure using the ultrasound technique, and to evaluate the bone gain obtained. Materials and methods: In 21 patients, 26 sinus lifts were performed using ultrasound and filled with bone graft material. The bone height and the bone gain obtained were observed in postoperative orthopantomographs, correcting for previous distortion. Results: Of the 26 maxillary sinus lifts, 4 Schneiderian membrane perforations were observed. The average bone height prior to the intervention was 3.5 mm (scale 0.6- 8.7 mm ) and the average postsurgical bone height was 10.8 mm (scale 7.5- 15.6 mm). An average bone gain of 7.2 mm was observed (range 2.5- 11.7 mm). Conclusions: Based on the results of this study, during ultrasound sinus lift, few Schneiderian membrane perforations occurred and all were small .
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    The implant-supported milled bar overdenture : a literature review
    (2010) Bueno Samper, Antonio; Hernández Aliaga, Manuel; Calvo Guirado, José Luis
    Purpose: This bibliographical review aims to determine the present situation of the implant-supported milled bar overdenture as a therapeutic option in implantology, as well as to set and compare the techniques and materials currently used for making them. Materials and methods: By searching the main electronic bibliographical data in indexed Medline articles, we obtained a total number of 20 articles that fulfilled the requirements of this bibliographical review. Results: The implant-supported milled bar overdenture offers excellent long-term successful results, although complication rates are higher in emergency cases of patients initially planned for a fixed prosthesis. Krenmair and collaborators found cumulative survival rates of implants on milled bars after 5 years, of 99% in mandible cases, and of 97.8% in maxilla cases. No detailed protocols specifying the necessary number of implants or their characteristics have been found, though they are never made with less than 4 implants in mandible or 4-6 in the maxilla. Milled bars are screwed, generally cast in a precious metal alloy, with a metal or acrylic suprastructure and include attachments that regulate the tightness. The suprastructure adjusts precisely and rigidly to the milled bar, and presents similar biomechanical movements to those of fixed prostheses. The overdenture is removable and its prophylaxis is simple. Conclusions: The implant supported milled bar overdenture is a very interesting option in the treatment of patients with moderate to severe reabsorbed maxilla problems. It offers both the advantages of removable prostheses as well as the stability and retention of a fixed prosthesis.
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    Current status of the torus palatinus and torus mandibularis
    (2010) García García, Andrés S.; Martínez González, José María; Gómez Font, Rafael; Soto Rivadeneira, Ángeles; Oviedo Roldán, Lucía
    While there is a hereditary component to tori, this does not explain all cases. Tori tend to appear more frequently during middle age of life; the torus palatinus is more commonly observed in females, but this is not the case with the torus mandibularis. Certain ethnic groups are more prone to one torus or the other. The torus is mainly removed due to prostodontic reasons, as it may also be used as biomaterial, not only in periodontology, but also in implantology. The aim of this study was a review of the literature from the past twenty years.
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    Autogenous calvarium bone grafting as a treatment for severe bone resorption in the upper maxilla : a case report
    (2010) Díaz-Romeral Bautista, Miguel; Manchón Miralles, Ángel; Asenjo Cabezón, Jorge; Cebrián Carretero, José Luis; Torres García Denche, Jesús; Linares, Rafael
    Atrophic maxilla rehabilitation has been the subject of several studies for decades; despite this, there are still many different therapeutic choices for the best way to treat maxillary resorption in order to enable implant placement and integration. These possibilities include the optimal use of remaining bone structures, such as the pterygoid processes or zygomatic arch, which involves using zygomaticus and pterygoid implants in combination with standard implants placed in the residual bone; alternatively, regenerative techniques, alveolar bone expansion/distraction or bone grafting techniques may be used. Severe maxillary atrophy has a multifactorial aetiology; the most important factors being long evolution edentulism, hyperpneumatization of the maxillary sinus, post-traumatic deficit, bone loss after surgery (tumours, cysts) and periodontal problems or infection. In this report, we present a clinical case of onlay block reconstruction in an atrophic maxilla with harvested cranial calvarium bone grafts for successful future implant-supported oral rehabilitation.
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    Granulocytic sarcoma of the oral cavity in a chronic myeloid leukemia patient : an unusual presentation
    (2010) Santos, Paulo Sergio da Silva; de Freitas Silva, Brunno Santos; Coracin, Fábio L.; Yamamoto, Fernanda-Paula; Júnior, Décio-dos-Santos-Pinto; Magalhaes, Marina H.C.G.
    Intraoral granulocytic sarcoma is an unusual manifestation of chronic or acute leukemia. The oral manifestations often involve enlargements of the gingival and mucosal tissue from direct leukemic cell infiltration. Only 38 cases have been reported in scientific literature to date. We present the case of a 47 year-old female who was diagnosed with chronic myeloid leukemia (CML) in December 2006. She was referred to a dentist for further evaluation, revealing generalized gingival overgrowth as well as periodontal, apical disease, and bleeding of the gums. An oral biopsy was performed and histological features revealed immature blast-like cells.
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    Osteolipoma of the buccal mucosa
    (2010) Castro, Alvimar Lima de; Castro, Eni Vaz Franco Lima de; Felipini, Renata Callestini; Ribeiro, Ana-Carolina-Prado; Pires Soubhia, Ana Maria
    Lipomas are benign mesenchymal neoplasms of soft tissue that can be found in any part of the human body. Conversely, their presence in the oral mucosa is rather uncommon, with approximately 4% of the cases occurring in the oral cavity. In such cases, they are likely to have originated from mature adipose tissue and to be among several described histological variants of lipomas, which are identified according to the predominant type of tissue. There is a rare lipoma, known as an osteolipoma or an ossifying lipoma; however, little has been written this type of lipoma characterized by a classical lipoma with areas of osseous metaplasia. Considering the few cases of oral osteolipomas previously described in the English-related literature and the consequent risk of misdiagnosis and overtreatment, this paper describes an extreme case of an osteolipoma affecting the buccal mucosa of an adult patient. This paper focuses particularly on the pathogenesis of this lesion and the discussion of a correct diagnosis.
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    Intraoral epithelioid hemangioendothelioma : a case report and review of the literature
    (2010) Gordón Nuñez, Manuel Antonio; Silva, Leonardo Miguel Madeira; Lopes, Maria Fernanda Fernandes; Oliveira-Neto, Sebastião Fernandes de; Maia, Alexandre Pinto; Galvão Cavalcanti, Hébel
    The epithelioid hemangioendothelioma (EH) is an uncommon angiocentric neoplasm of borderline or intermediate malignant potential, between the hemangioma and conventional angiosarcoma. It is characterized by the proliferation of endothelial cells with epithelioid or histiocitóide morphology with vacuolated cytoplasm and occasional eosinophilic spindle cells. Shows potential for local recurrence as well as the ability to metastasize. Rarely affects the oral cavity, it have been described from 1975 until 2008 only 27 oral cases. Morphologically the EHs may be confused with other lesions, from a hemangioma to a squamous cell carcinoma, and thus immunohistochemical analysis is required. This paper reports the clinical and immunohistochemical characteristics of a case of EH in the gingiva of the tooth 35 of a 17 years-old-white-female. We present a review of the clinicopathological and immunohistochemical characteristics of the intraoral epithelioid hemangioendothelioma cases previously reported.
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    Immunohistochemical study of Langerhans cells in periapical lesions : correlation with inflammatory cell infiltration and epithelial cell proliferation
    (2010) Carrillo García, Celia; Peñarrocha Diago, Miguel; Peñarrocha Diago, María; Vera Sempere, Francisco José; Peñarrocha Oltra, David
    Aim: The aim of this study is to determine the presence and distribution of Langerhans cells in periapical lesions, and correlate this with inflammatory cell infiltration and epithelial cell proliferation. Material and Methods: Seventy chronic dental periradicular lesions, obtained during periapical surgery from 70 patients, were included in this study, including: 46 granulomas, 18 scar tissue and 6 periradicular cysts. Immunohistochemical staining was performed using the following markers: CD3 to analyze the inflammatory infiltrate, CD1a to determine the presence of Langerhans cells and Ki67 to analyze the epithelial cell proliferation. The CD1a immunostaining density was established following Cincura (2007) criteria, being classified ranging from intense (3), moderate (2), discrete (1) or no (0) immunostaining. CD3 and Ki67 staining was evaluated following the Liapatas et al. scale, as: 0) no cells stained; 1) weak stain or few cells stained (11-25%); 2) moderate staining or some cells stained (26-75%); 3) intense staining or many cells stained (more than 76%). Results: Langerhans cells were found in 32.8% of the periapical lesions being more intense in the epithelialized lesions. CD3 immunohistochemical staining was found in all lesions, but with different values in relation to histological subtypes. Ki67 was positive in all epithelialized lesions, although with a moderate staining. Conclusions: Langerhans cells appeared to be associated with T-lymphocyte infiltration and the proliferative potential of the epithelial tissue in periapical lesions
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    Evaluation of cell proliferation rate in non-dysplastic leukoplakias
    (2010) Hildebrand, Laura de Campos; Carrard, Vinicius C.; Lauxen, Isabel da Silva; Quadros, Onofre Francisco de; Chaves, Anna Cecília Moraes; Sant'ana Filho, Manoel
    Objective: Analyze whether the most frequent cases of non-dysplastic leukoplakias, hyperkeratosis (H), acanthosis (A), and hyperkeratosis with acanthosis (HA) have similar cell proliferation rates and to compare them with epithelial dysplastic (ED) leukoplakias and normal oral epithelium (NOE).Study design: The sample comprised 10 cases of normal oral epithelium, 10 cases of hyperkeratosis, 10 cases of acanthosis, 10 cases of hyperkeratosis with acanthosis and 10 cases of epithelial dysplasia. The mean number of AgNORs per nucleus (mAgNOR) and the mean percentage of cells with 1, 2, 3 and 4 or more AgNORs per nucleus (pAgNOR) were recorded. Results: The results of mAgNOR showed differences between disorders in the evaluation of the basal layer, of the parabasal layer, and in the overall evaluation. mAgNOR and pAgNOR=2 increased progressively from normal oral epithelium to hyperkeratosis with acanthosis, hyperkeratosis, acanthosis and epithelial dysplasia (p<0.05). Cell proliferation rate was different between different subtypes of non-dysplastic leukoplakias and this group presented a higher proliferative behavior when compared to normal oral epithelium. Conclusion: It may be suggested that non-dysplastic leukoplakias had different characteristics regarding cell proliferation rates and sometimes showed a proliferative behavior similar to that found in epithelial dysplasia. More studies should be conduced to increase knowledge about the biological profile of non-dysplastic leukoplakias, especially as it pertains to acanthosis.