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Journal of Ozone Therapy. 2018. Vol. 2, no. 2

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Ozone Therapy : Scientific updates and researches in recent years [abstract]
(2018) Menéndez Cepero, Silvia
Ozone medical applications gather strength, day by day. Ozone, in its oxidant status, administered in low doses and in a number of controlled treatments, is able to trigger the endogenous antioxidant systems achieving a redox balance. As such, it is able to control chronic oxidative stress associated with many diseases. Moreover, levels of nitric oxide and pro-inflammatory cytokines, like tumor necrosis factor (TNF-alfa) and interleukin 1 and 6, were able to be modulated by ozone. Also, mitochondrial integrity and functionality was preserved, calcium homeostasis was achieved, adenosine A1 receptors were activated and activity of the superoxide dismutase enzyme was regulated [1]. In this lecture, preclinical and clinical studies of recent researches developed in Cuba are presented. Two topics have been selected: Alcoholism [2,3] and arthritis [4,5]. In today's world, alcoholism is a serious health and social problem, affecting millions of people, without distinction of race, sex, culture or latitude. One diagnostic criterion of alcohol dependence is the appearance of a withdrawal syndrome when alcohol consumption ceases. Experimental studies have demonstrated that many consequences of withdrawal found in animals resemble those observed in humans. Such signs and symptoms of ethanol withdrawal (EW) include enhanced activity of the autonomic nervous system; body posture and motor abnormalities; hyperexcitability of the central nervous system (CNS), including sensory hyperreactivity, convulsion, anxiety, etc. Chronic ingestion of high levels of alcohol may bring about oxidative stress, associated with hepatic alterations, and of CNS, mainly due to the formation, through alcohol metabolism, of free radicals, acetaldehyde, lipid and protein oxidation and their reaction products. The protective effects of ozone on brain injury induced by oxidative stress and behavioral changes in rats, after 2 weeks of EW, were studied [2]. Also, a clinical trial with 10 alcoholic patients (elapsed time after ethanol withdrawal: less or equal than 3 weeks) treated with ozone by rectal insufflation (ozone concentration from 20 to 35 mg/L and volumes from 100 to 150 ml) was performed [3]. In the preclinical study [2], 4 groups of rats (n=10 each one) were settled: I-Control, II-Ethanol, III- Ethanol + Ozone (20 mg/L, dose of 1 mg/kg, 10 sessions by rectal insufflation) and IV- Ethanol + Oxygen. At the end of EW, rats were subjected to behavioral tests followed by brain tissue collection to measure markers of oxidative damage. Ozone increased food consumption, maintained water intake at the same levels as the control group and reestablished cellular redox status. Anxiety, locomotor activity and memory/learning of the rats were improved. Ozone protected the brain against oxidative injury, improving important functions of the CNS. In the clinical study [3], the results demonstrated that ozone improved 70% of the signs from Clinical Institute Withdrawal Scale (CIWA-Ar), mainly those associated to CNS. Ozone efficacy was observed in patients that required pharmacological treatment. Reduction of CIWA-Ar scores and the oxidative stress (p
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Knee and Hip Osteoarthritis [abstract]
(2018) Baeza Noci, José
Introduction. The use of ozone, intra or periarticular, for knee and hip joint osteoarthritis (KO / HO) is clearly justified by its anti-inflammatory and antioxidants properties, that should diminish the arthritic episodes of this disease [1]. Several papers have proved the safety and efficacy of this treatment for KO [2-12], comparable to other classical treatments (steroids or hyaluronic acid (HA)) [13-14]. However, there is no paper about HO yet. Study design. This work is based on two open prospective studies started in February 2002 and stopped in February 2010, one group for each joint. Recruitment criteria for both groups were: - Kellgren & Lawrence KO classification: any - One/bilateral - No previous joint trauma - No rheumatic disorder - No previous surgery (but arthroscopic meniscectomy) - NSAIDs for at least two months - Promise to abandon any anti-inflammatory drugs during ozone treatment - Informed consent Clinical evaluation for KO was done using WOMAC questionnaire, pre-treatment and 1, 3, 6, 12 months after treatment. In case of HO, we used VAS for evaluation instead. Clinical data. All patients have, at least, 12 months follow-up. For KO, we have complied 199 patients (225 knees). There are two missing cases, not compiled, due to death at the 1 year revision. Age of sample ranged from 51 to 89 during the treatment. WOMAC pre-treatment was: -Pain 13.3 -Stiffness 5.6 -Function 46.2 Other data compiled, were: age, gender, BMI, Kellgren & Lawrence radiological scale (I to IV) and relapses (time free of symptoms). For HO, we have compiled 126 patients (133 hips). There are no missing cases at one year follow-up. Age ranged from 49 to 83. EVA pre-treatment was 7,33. Other data compiled, were: age, gender, BMI, use of imaging, Kellgren & Lawrence radiological scale (I to IV) and relapses (time free of symptoms). Ozone technique. All patients got one intarticular injection of ozone, once a week; in case of associated tendinitis or bursitis, a second or third injection was done together the intrarticular one. Injections were performed under strict asepsy. For the knee, we used a 27G x 30 mm needle with a syliconized syringe and a supero-lateral approach and. Ozone dose for intraticular injection was 15 mL at 20 mcg/mL.[15-16] Paratendon injection was performed with 5 mL at 20 mcg/mL. We always did a minimun of three intrarticular injections. Patients that did not improve were classified as failure. For the rest of the patients, the average number of injections was 4,8 (range 3 to 7). For the hip, we used a 25G x 90 mm needle with a syliconized syringe and a lateral approach. Ozone dose for intraticular injection was 5-10 mL at 20 mcg/mL.[15-16] Paratendon injection was performed with 5 mL at 20 mcg/mL. 45 patients were injected with imaging guide due to severe obesity. In these patients we used a 22G x 205 mm needle. We always did a minimun of three intrarticular injections. Patients that did not improve were classified as failure. For the rest of the patients, the average number of injections was 5 (range 3 to 10). Results. From 225 knees, 44 (19.5% - the ?bad result? group) did almost not improve at all; other rescue treatments were offered. The rest (80.5%) achieved a significant improvement, increasing WOMAC index over 25% of their basal level. The clinical improvement was obtained during the treatment or the first three months after treatment. WOMAC global improvement was 48%, including both groups. Relapses over the ?good result? group have been of 8% at 1 year revision, and are statistically related just with Kellgren & Lawrence classification. We registered no side effect that needed further treatment. From 133 hips, 80% improved at least 2 points in VAS and 73% improved at least 3 points. The one month follow-up VAS score was 3,3 (improvement of 55%). From the patients that improved, 25% had a relapse at 1 year visit, and are statistically related just with Kellgren & Lawrence classification. The use of imaging support did not improved the results. We registered no side effect that needed further treatment. Discussion. Results for KO are similar to Moretti's paper [12] and similar to the ones published for HA papers [15]. These last papers are almost always referred to 6 month follow-up. Comparing our results with HA papers at one year follow-up, they are clearly better. Longer term results for HA are even worse. This study has flaws due to its design, but similar design has been used for reporting results about drugs, HA or surgery, so comparison can be done. For HO, the results are even better that the one published for steroids or HA injections [16-17]. We agree with the publication about the use of imaging [18]. Conclusion. Ozone treatment in KO improves clinical outcomes over 25% of its base level in more than 80% of the patients. Relapse rate is 8% and is related with advanced osteoarthritis (Kellgren & LAwrence grades III-IV); minimal time free of symptoms is almost one year. The similarity with Moretti's results in a double blind clinical trial strength the indication for ozone in patients with KO. No paper has been published yet about HA, but comparing the results with steroids or HA injections, this treatment option is promising.
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Chronic Kidney Disease - CKD [abstract]
(2018) Kakkad, Vipul J.
Total Number of CKD patients treated with OZONE THERAPY (rectal or IV saline): 40 (Most of them are under the treatment of Nephrologists) Two categories: - Serum Creatine 3 till 14 (Stage 4-5) No. of pts.17 1) Improvement observed for Stage 1-2-3 that is 1st category: On the basis of Clinical evaluation & Pathological criteria, 100% pts. improvement, with stable patho & physiological criteria, for more than 18 months 2) Improvement observed - for Stage 4-5 that is 2nd category: - On the basis of Clinical evaluation & Pathological criteria, 80% pts. Improved - Clinically & Pathologically. (Stable for > 3 months). - No improvement was observed in 20% of pts. 60% patients have shown Clinical & Pathological improvement & maintained for 6-12months. 80% patients have shown Clinical & Pathological improvement & maintained for 3-6 months. Clinical improvement as follows: - Anorexia decreased - Sense of well-being improved - Energy level increased - Edema decreased - No changes in weight except +/- 1kg. Pathological improvement: - Hb improved - Serum Creatinine & Serum BUN reduction - Proteinuria decreased. Ozone rectal insufflation are found to be more effective than IV ozone saline. Conclusion: Patients who received rectal ozone continuously for more then 10 procedures are better improved and could maintain the improvement.
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Efficacy and safety of Ozone Therapy for patients with chronic hepatitis B : A multicenter, randomized clinical trial [abstract]
(2018) Yu, Hong; Chen, Pingyan; Chen, Jilin; Dai, Wei; Wu, Zhimin; Guo, Yabing
Background. Ozone therapy has a long history. Some studies proved that ozone therapy was useful in treatment of virus hepatitis.Objective: To evaluate the efficacy and safety of new medical ozone therapy system for the treatment of chronic hepatitis B. Method. One hundred eighty-nine patients with chronic hepatitis B were included in this open-label, phase 3 study, and randomly assigned to receive ozone autohemotherapy with experimental ozone generator TianYi (group 1) or with ozone generator Humares (group 2) or oral diammonium glycyrrhizinate capsules (group 3) in a 1:1:1 ratio for 12 weeks. The primary efficacy end point was sera HBV DNA level of less than 1×103 IU/ml or having a more than 2 log10 reduction in HBV DNA level at the end of 12 weeks treatment as compared to baseline HBV DNA level. Secondary end points included HBeAg seroconversion, biochemical response, and combined response. Results. At the end of 12 weeks treatment, the proportion of patients reached the primary end point of virologic response in group 1, group 2, and group 3 were 22.4% (13/58, 95% CI, 12.5 to 35.3), 14.7 (9/61, 95% CI, 7.0 to 26.2) and 3.9% (2/51, 95% CI, 0.5 to 13.5), respectively (p=0.021) in the pre-protocol population. Virologic response occurred in more patients receiving ozone therapy with experimental device than patients receiving oral diammonium glycyrrhizinate capsules (mean difference 18.5%, 95% CI 6.3 to 31.5, p=0.005). However, there was no statistical difference in VR12 rates between the treatment of medical ozone therapy system with experimental device (group 1) and with Humares (group 2) (mean difference 7.7%, 95% CI -6.5 to 22.0, p=0.282). More HBeAg seroconversion in patients treated by Tianyi ozone therapy system than those treated by Humares ozone therapy device and oral diammonium glycyrrhizinate capsules (14.8%, 5.1% and 7.3%, respectively, P = 0.272). Higher biochemical response rate was observes in patients receiving ozone therapy than oral diammonium glycyrrhizinate capsules (31.6%, 36.7% and 24.0%, respectively, p = 0.359). The safety profile was similar for the three treatment groups and adverse events were .scare infrequent and mild. Conclusions. Ozone therapy had superior antiviral efficacy with a similar safety profile as compared with oral diammonium glycyrrhizinate capsules through week 12 treatment. Ozone therapy is also associated with normalized ALT and AST levels, demonstrating that ozone therapy could benefit the patients with chronic hepatitis B.
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Extra Corporeal Oxygenation & Ozonation, EBOO & AQUAPHERESIS method of Ozone Therapy, Clinical Application in Chronic Diseases [abstract]
(2018) Yong Yean Sirn, Kenny
Introduction. The top 10 causes of death around the world are usually ranked with heart diseases, cancers, drugs/medication/iatrogenic chemicals, strokes etc. These are totally detectable, predictable, avoidable, preventable because it is classified as non-communicable diseases. Acute diseases are denoted by acute inflammation which has intensive cell-cell communications, resulting intensive repair rebuilding rehabilitation and it is life extending. Often it is self defensive and we over come it. The real culprit for chronic diseases is chronic inflammations, denoted by constant and silent, undetectable and insensible lost of cell-cell signaling, basement membrane disease, tight junction destructions, mitochondrial dysfunctions, mismatched metabolism, nutritional losses, mineral depletion, hormonal imbalances, opportunistic antigenicity wasting away the helpful immunity, leading to immune senescence and stem cell depletions eventually leading to chronic degeneration and devastating incapacitated regeneration ability. Often it is self destructive and we usually succumb to it. Mitochondrial decay & incapacitation of oxygenation and aerobic respiration failure leading to chronic anaerobic conditions breeding many chronic diseases. Ozone therapy is one of the best method to reverse chronic diseases. Its hormetic response curve of 10 to 80 gamma units typically reveals the secret of ozone healing hormesis. The low dose concept is to be respected all time. And with in safety limits we can practice low & escalating dosage, with increasing in volume of blood exposure to ozone, to evolve from minor AHT to major AHT, all the way into continuous auto-hemotherapy via extra-corporeal blood circuits with the proper method. Its action on mitochondrial health and its regenerative power is well known and documented. Method: 1. Ozone properties and therapeutic applications and methods of extracorporeal circuits 2. EBOO / AQUAPHERESIS set up and therapy method 3. Safeties and precautions, limitations and patient selections 4. Selections of machines and GED gas exchange devices 5. Therapeutic steps for patient, and adjuvant photonic therapy 6. Post therapeutic monitoring and documentations 7. Clinical results of various cases treated with EBOO and AQUAPHERESIS Results. Definition of extra corporeal circulations method would be discussed. Original EBOO therapy method and scientific studies would be reviewed. A modified economical method of EBOO would be illustrated. A further improvised AQUAPHERESIS method of continuous blood ozonation / oxygenations would be illustrated and discussed. To ensure safety and long term success, selection of machines, materials, circuits, disposables, disposal of dialysates and ozone residue, all the way to selections of dialyzer and GED gas exchange devices would be discussed. Dangers of wrong machines and wrong GED/Dialyzers with related precautions to be considered during EBOO and AQUAPHERESIS would be discussed. A few case study would be illustrated and discussed. Conclusions. Ozone is a wonderful new well known medical drug. Its benefits is vast and economically easily available. Within the safety limits we can extend the ozonation and oxygenation of blood to a much longer, larger therapeutic window via the extra corporeal circuit method. Both EBOO and AQUAPHERESIS are additional interesting method to deliver ozone therapy to patient reaping also the benefits of plasma apheresis in AQUAPHERESIS method. With correct knowledge and higher standard of machines and disposables, these methods are safe and effective to be applied to patient and it deliver significant result clinically. Further studies are encouraged and worth explored.
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Ozone Therapy : General protocols based on evidences [abstract]
(2018) Menéndez Cepero, Silvia
Ozone has been used as a therapeutical agent for the treatment of different diseases and beneficial effects have been observed. However, ozone biological effects remain controversial due to the scarce knowledge of its biochemical and pharmacodynamic mechanisms [1]. Taking into account that ozone therapy is gathering more interest, day by day, and it has been used in apparently nonrelated diseases with beneficial effects, the National Center for Scientific Research (Havana, Cuba) in collaboration with different research centers and health institutions have studied the ozone toxicology and its pharmacological actions as well as its biochemical mechanisms. The most remarkable experiences, in preclinical and clinical studies, developed in Cuba during the last 30 years, in order to prove unequivocally ozone therapy validity, are presented in this lecture. On the basis of the oxidant properties of ozone, we postulate that controlled ozone administration (named as ozone oxidative pre-/postconditioning mechanism) is able to promote a slight and transient oxidative stress which in turn re-establishes the signalling pathways which have been lost in pathological conditions, preserving the cellular redox balance (increasing antioxidant endogenous system), mitochondrial function as well as the regulation of transcription factors and the modulation of the immunological system [2]. It is evident that membrane-associated ozone peroxides, 4-hydroxialkenals, superoxide anion, nitric oxide, among others, are going to play an important role in cellular signals as well as in the pathology of different diseases [2,3]. Regulation of these biomolecules by ozone preconditioning has been demonstrated in several preclinical and clinical studies as ischaemia-reperfusion phenomenom, parkinson, senile dementia, disk herniation, retinitis pigmentosa, ischemic cardiopathy, arterial insufficiencies, diabetes, osteoarthritis, asthma, vestibulocochlear syndrome, among others [2,4]. Nitric oxide modulation, as well as the increase in A1 adenosine receptors achieved with this therapy has an important role in brain blood flux, in the formation of memory, in the release of neurotransmitters and in the inflammatory processes [5,6]. Ozone therapy seems to induce a simultaneous resuscitation of functions that had gone wrong, reactivating and re-equilibrating physiological activities. This lecture contributes to clarify the ozone mechanism of action and its different pharmacology effects. It is concluded that ozone therapy can be useful in the treatment of several diseases, either as adjuvant of ortodox medicine or taking part positively in those where conventional therapy has had no success, all this with a common purpose: to favour the patients and contribute to a better quality of life.
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Ozone Therapy in joint pathology [abstract]
(2018) Shah, Gautam
Aim. Ozone therapy is minimally invasive procedure for the treatment of various medical problems including osteoarthritis, frozen shoulder etc .We report the treatment on a series of patients affected by joint pathology, treated by injection of oxygen-ozone gas mixture. This is an experience of treating acute and chronic disease of the large joints (knee, shoulder, hip) by intra and peri-articular injections of an oxygen- ozone gas mixture. The patients were assessed before and after treatment. In addition to a resolution of joint pain, patients had a good functional recovery of their daily activities and the treatment was well-tolerated. Methods. Forty?three patients, ages ranging from 32 years through 76 years were treated with the injection of oxygen-ozone mixture. Indications for treatment were hip and knee osteoarthritis, and frozen shoulder .All patients were treated with multiple, intermittent injections at regular intervals. Under local anesthesia approximately 20 ml of an ozone-oxygen mixture of 10ug/ml ozone was injected with1a 22G needle puncture under C ?arm guidance where necessary. After 2 and 6 weeks patients were asked to rate the treatment success on a numeric pain scale from 0 to 10.Patients were put on a rehabilitative physiotherapy program at 2 weeks. Results. After 2 weeks, most patients had satisfactory pain relief of various degrees. Four patients reported no change (all had advanced stages of osteo arthritis). On follow up, 2 of those had effective pain relief while the remaining 2 had no change, and went on for surgery. At a 6 week follow up pain relief was still satisfactory for all. Conclusions. Joint disorders can very successfully be treated by means of oxygen-ozone mixture locally administered. The medical ozone injection is thought to affect both the mechanical and inflammatory components of pain. Ozone therapy is a promising treatment option for patients with symptomatic joint pathology, failed conservative therapies, and are not considered candidates for open surgery.
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The long and winding road.
(2018) Baeza Noci, José
It has been a very long trip since I wrote my last editorial. The first issue of the Journal received a strong welcome from all over the world in the beginning of 2016, but there was something missing that drove us to a winding road that ended in an even stronger situation: the support of the University of Valencia?s Publication Service (UVPS). The missing thing in the first issue was the DOI (Digital Object Identifier). All the online journals have a DOI to identify the papers and allow a permanent link to them. Each DOI is unique for each paper. We look for a DOI provider in our environment and found the UVPS to offer DOIs for free to their teachers. As I am one of them, I went to ask for the requirements and the first one was to have an Open Journal; I emailed the WFOT Board and all agreed to change our journal policy to an Open one. Then, the University offered us to use their Open Journal System (OJS) of edition for free. This was a hard decision to take, because we have spent many hours developing our own free edition system, but the UVPS?s OJS offered something else ? free indexation! So we decided to move the edition process to OJS. It took us ONE YEAR to setup the OJS for our journal and when we finally got it ready, our journal web site (www.jo3t.org) was HACKED. We had then to change our domain name to the current one and use a secure protocol to access the journal (https), modify some security issues and move the contents of the old web site to the new one. Who says that the editorial work is boring? Many papers for issue 2 had been sent using the old editorial manager, so we move them into the new OJS; some authors suffered this migration. Thanks for the patience! Lately, is was impossible to get 10 papers for the second issue in 2017, so we decided to postpone the papers compiled for issue number 2 to issue number 3 and devote this second issue to be the Proceedings of our 5th WFOT Meeting in Mumbai ? India. We upload all the abstracts to the system, that have been peer reviewed and language checked by our language copyeditor. When all this was done, the UVPS updated OJS and included a tool for NLM/Pubmed export that obliged us to re-review the papers for a proper indexation. To finish our trip, we got our desired DOIs for our journal?s papers and we are ready for Pubmed indexing. The papers planned to be published now have been assigned to issue number 3, we want to publish this year in June-July. We have already papers for issues numbers 4 and 5 (2019) so I am happy to say that the Journal of Ozone Therapy is rolling on!!! Again, thanks to every author for their patience. Now we start pushing for Pubmed indexation and have good Impact Factor. We have the tools and the help of the UVPS, but we need you all to get the journal we all need and want.
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Ozonated Water, Ozonated Water, Ozonated Oil and its Products [abstract]
(2018) Captain, Jignasha
Most of us are aware that ozone is basically a treatment of pure oxygen and its effect on the human body is even better. As our human body is made up of 70% of water, we used ozone in many different way, one of them is what we know as ozonated water. As ozone when mix in water it diluted thoroughly and highly purifies the water, as it is soluble in water. It maintain its tri-oxygen identity. Biological Properties of Ozonated Water: ? It kills viruses, bacteria, fungi and algae on contact. ? It breakdown harmful synthetic chemicals into less dangerous molecules. ? It purifies the blood by rupturing the cell wall of the microorganisms. ? It kills some cancer cells, slows tumor growth, and may stop the spread of cancer. ? It provides more oxygen to the brain. ? It boosts the immune system. Preparation of Ozonated Water: In order to prepare this, we first use the glass cylinder filled with approximately ¾ of pure water (mineral water) through which O2-O3 gas mixture has to be bubbled continuously for at least 5-10 minutes by using diffuser to achieve saturation. The unused ozone flows out via silicon tubing in to the destructor and is converted to oxygen. As ozone physically dissolve in water therefor it's concentration is equally to approximately ¼ of total O3 concentration in gas. If put at 20 degree, half-life of it is only 9 hours and if put at room temperature half-life is approximately 4-5 hour, only if maintained properly. The stability of ozonated water depends largely on the temperature and also ionic contents and Ph. of water. Colder the water more ozone is absorbed and retained for a longer rate. Drinking Ozonated water Local Treatment Dental use Allergies Ankle sprain Aphthous stomatitis Cancers Athlete's Foot Candida Gastritis, indigestion Fresh/recent wounds Gum disease Candidiasis Burns - arms & legs Mouth ulcers Headaches Herpes zoster and simplex Wound treatment Viral infections Pains due to bad peripheral Disinfection after tooth blood circulation extraction & dental work Indication of Ozonated Water: - Ozonated water is helpful in following diseases: Drinking ozonated water is highly energetic water. It has to be drunk immediately on empty stomach. On regular use of ozonated water will establish high level of oxygenation in the body. Topical application: Ozonated water is basically applied on account of its pain relieving, disinfectant and anti-inflammatory effects as well as tissue activating property in acute & chronic injuries with & without infection. Ozonated water also being used intra operatively for rinsing. The healing time for primary scar is shortened and irritation free. Dental use: Ozonated water strongly inhibited accumulation of experimenter dental plaque in vitro. Ozone destroys this niche in which acid loving bacteria grow. Ozone also destroys the protein coat over the lesion, which effectively protect the niche. Ozonized water can offer an efficient non antibiotic agent for the control of microorganism prior to replantation of contaminated avulsed teeth. - Ozonated Oil and Products: Ozone therapy has been in India since over 2 decades. Every year, the awareness among people increases rapidly due to the factor that ozone has help a lot of people in curing the disease and medical problem. As ozone has been in India for over 2 decades now, there is a body that takes care and helps in not only promoting ozone but also manufacturing and distributing ozone product. Till the date Ozone Forum Of India have come out with eight different product and still researching and working in introducing more products, and we are still working on research and development of further new products. Ozonated oíl is made by using pure vegetable sesame oil and it prepare by bubbling the O2-O3 gas mixer for about 100 to 200hrs. After this it becomes more viscous. Due to prolong ozonation, it results in the formation of ozonides and peroxide which remain stable for 1 year at room temperature and for 2 year in refrigerator. In India, after completion of full procedure in order to check the degree of ozonation we use viscosity measurement and peroxide value, finally the viscosity increase up to 60% indicating that double bonds in oil has reacted with ozone to form more bulky molecules. For peroxide value which is maintain between 300 to 2000 by checking peroxide, represents the quantity of peroxide expressing in mili equivalent of active oxygen contained in 1kg of the oil. As ozonides and peroxide are the main active ingredients therefore triozonide become stable and comes into contact with the warm exudate of the wood. This then, slowly discomposes and generate reactive oxygen species (ROS) and lipid oxidation products (LOPs). This explains the prolonged disinfectentant and stimulatory activity. Ozonized oil helps in: Controlling bleeding, Disinfecting the lesion, Inhibiting the proliferation of potentially infective organisms, Improving metabolism, Stimulatory tissue regeneration, . . Thus, FAST HEALING. In India, we have eight (8) different types of ozonized products: RAPID HEAL Oil is pure vegetable sesame oil with peroxide value is about more than 1500. It has a powerful germicidal effect and hence helps in all kind of skin related disease, non-healing ulcer, burns and dental pathology. PAIN RELIEF is healthy and safe massaging oil with main active ingredient is ozonized oil. It helps in relieving all kind of musculoskeletal pain. PAIN BALM is an instant pain relieving products. It is an extremely effective balm for body ache and joint pain. As ozonized oil is a major ingredient and due to which it helps in inflammation and reduce swelling and pain instantly. HAIR REVIVE is an effective hair oil for nourishing scalp and hair and makes hair healthy and smooth and shiny. Due to ozonated oil is an active ingredient it is very effective in dandruff and dry scalp. ANTIACIDITY OIL is excellent oil for the treatment of all kind of acidity related problem of the body. Using a unique formula with ozone, it helps in maintaining a good health by removing anaerobic germs from intestinal tract. At the same time it makes the immunity of the body stronger. SKIN BLOSSOM is a unique formula of cream with Ozonated oil is an active ingredient. Due to the pollution people's skin are effected in major way, therefore we suggest you the skin blossom, which detoxified and hydrated the skin. It also repair the skin Tissue and helps in sun burn and protect the skin. MIRAKLE CREAM makes your skin young, bright and cleaner and smoother. With the unique formula with ozone it superoxide's the skin, which in true Increase the metabolic rate and energy of the skin and promotes cell healing. As miracle also act as antioxidant, on using regularly, it helps in reducing wrinkle, aging spots and damage of dull skin, which in turn skin looks younger.
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Ozone Therapy : Teratogenic study of ozone. Possible indications in obstetrics and gynecology [abstract]
(2018) Menéndez Cepero, Silvia
Ozone is a powerful oxidant, surpassed, in this regard, only by fluorine. Its doubtless strong reactivity has contributed to establish the dogma that ozone is always toxic and its medical application must be proscribed. However, ozone therapy has been used for therapeutic purposes since the beginning of the last century and its use is increasingly demanded nowadays [1]. For proper enlightenment and guidance of the person interested in the use of ozone for medical purposes, scientific documentation on the safety/toxicity profile of this acclaimed procedure becomes necessary. Taking into account that the National Health Regulatory Agencies require of documentation with scientific trials for sanitary registration of drugs and therapy procedures, different toxicological tests were performed in Cuba using experimental animals, following the guidelines from the Cuban Regulatory Agency, Food Drug Administration, International Standards Organization and the Health World Organization aimed at proving the safety of ozone therapy administration. In this lecture, the teratogenic study of ozone by rectal insufflation (RI) is presented [2]. Female Wistar rats (200-250 g) were divided into 3 experimental groups: 1- control (n=15), without any treatment; 2- treated with 1 mL of ozone (n=17) at a concentration of 34 µg/mL (150 µg/kg); 3- treated with 4 mL of ozone (n=17) at a concentration of 90 µg/mL (1600 µg/kg). Ozone was administered by RI during 10 sessions, from the 6th to the 15th day of gestation. The pregnancy was confirmed by the presence of spermatozoa in the vaginal exudates. It was considered that the animals with positive exudates were in the 0 day of gestation. In the 19th day of gestation, animals were euthanized by an ether overdose and the fetuses were obtained by cesarean. The number of corpus luteum, implantations, alive and dead fetuses, reabsorptions, as well as the weight and the length cranium-caudal of each fetus were registered. Alive fetuses were examined to find any external malformations. No toxic effect was observed in the pregnant rats subjected to the ozone treatment by RI. Mother weight gain did not show significant differences among the groups, neither the other indicators (number of corpus luteum, implantations, alive and dead fetus, reabsorptions). In respect to the fetus morphology, no external, skeletal or visceral malformations were observed. The weight and the length cranium-causal did not show significant differences among the groups. It is concluded that no teratogenic nor embriotoxic effects were found after the ozone application by rectal insufflation at the doses studied. With respect to the application of ozone therapy in Obstetrics, an update of the papers published about this topic was presented [3-6]. They referred the use of ozone therapy in: pregnant womens with hypertension, genital or no genital infections during pregnancy, threatened abortion, intrauterine fetal hypoxia, among others. For example, the effect of ozone therapy by rectal insufflation on fetoplacental blood flow in hypertensive pregnant women, with 24 weeks of gestation, indicated a better fetoplacental blood flow, achieving a greater oxygenation in the group treated with ozone plus antihypertensive treatment (methyldopa) in comparison with a control group treated only with the conventional treatment. Also, a reduction of methyldopa in 23.7 % of the initial doses was found in the ozone group as opposed to an increase of 40.8% in the control group. Another study about ozone therapy as the main component of the complex treatment of threatened abortion, using ozonated saline solution in the first (group I) or second semester (group II) showed a decrease in the molecular products of lipid peroxidation and a simultaneous increase in the antioxidant activity. Also, with ozone therapy the pregnancy was preserved and prolonged to the physiological terms of labor in 86% of patients inside group I and in 85% of patients inside group II. However, in the control group (conventional treatment) I and II, it was possible to preserve the pregnancy in 65 and 60% of cases, respectively. In the ozone group, 80% of newborn babies received 7-10 points (maximum value) according to Apgar's score, however, only 58.3% in the control group. In Gynecology, an interesting paper was reviewed about distal fallopian tube recanalization using ozone treatment. In the ozone group, the ozone was introduced in the uterine cavity and in the case of the control group, anti-inflammatory drugs and antibiotics was used. The overall recanalization rate was significantly higher in the ozone group (93%) as compared to the control group (79%) 6-months after intervention (p < 0.01). The re-adhesion rate in the ozone group was significantly lower than the control group (p < 0.01). The pregnancy rate after 12 months of intervention was significantly higher in the ozone group (59%) compared to the control group (43%) (p < 0.05). These results were highly encouraging and hold promise for treating distal tubal obstruction in infertile females. For inflammatory diseases in female genital organs, intravaginal ozone has been used. Ozone restores the body's own defense abilities by the normalization of vaginal mucosa local immunity, prevents the generalization of inflammatory processes, facilitates uterus healing, reduces the treatment time with no complications or side effects. In Cuba we have a vast experience in the use of ozonated sunflower oil in the treatment of vulvovaginitis, human papillomavirus, acuminate condyloma, genitalis herpes virus with very good results [7-9]. In summary, we can state that preclinical and clinical studies presented here about the application of ozone therapy in Obstetrics and Gynecology, in the different ways of ozone applications, do not demonstrate any adverse effect or complication. However, more controlled clinical trials are necessary to perform in order to prove the inocuity of ozone therapy, mainly in Obstetrics, where threre are still questions to be clarified.
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Ozone Therapy in Gynecology [abstract]
(2018) Bande, Sunayna
Explanation. Gynecology is a vast branch including study of many disorders related to female genital tract, menstrual cycle, female hormones, infertility etc. Ozone Therapy is helpful in many of these. PID - Pelvic Inflammatory Disease is a very common gynecological disorder caused by bacterial, fungal or other infections of genital tract and the pelvic area surrounding that. Ozone being an excellent antibacterial, antimicrobial and antifungal agent is very useful in treatment of PID. Ozone also gives very good results in cases of chronic PID which are resistant to many antibiotics, in such conditions, ozone gives better relief and also for longer time. INFERTILITY. When a female is unable to conceive after 1 year of married life without using any contraception, she is considered for investigations and treatment of infertility. Many causes of infertility can be divided into: - 1. Male factor - 2. Female Factor Female factor infertility ? Infertility arising out many female factors, Ovarian and Tubal factors respond well to ozone therapy. Tubal block due to inflammation may be treated with ozone therapy. Ozone given Vaginally can reduce the inflammation at the cornue or in tubes and open the block. Ovarian factors are complex to treat. Problems like Anovulation, Ovarian cyst, Polycystic Ovaries can be treated with ozone therapy. Encouraging results have been found with Ozone therapy in PCOS with infertility. In my presentations, I am going to present a few cases of above conditions.
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Ozone Therapy : mechanisms of action, recent literature and newly discovered biochemical pathways [abstract]
(2018) Re, Lamberto
Ozone therapy is widely used in many countries since many years. Recently, the increasing widespread of this complementary therapy has been accomplished by an increased number of basic and clinic papers published on international journals. This lecture will deal on the first approach by a pharmacological point of view in the aim to characterize the mechanisms activated at sub-cellular level by ozone when used for medical and beauty application at low graded doses. The first theory was based upon the fact that the exposure to low, non-toxic, ozone concentrations could increase the efficacy of the endogenous antioxidant system by increasing the production or the activity of some enzymes exerting a key role in the mitochondrial respiratory chain. Many of the basic mechanisms of the ozone action are now well outlined. In addition, the modulation of interleukins productions and of some biochemical pathways related to inflammation and pain, indicates the rationale of its use in many pathological conditions related to pain, inflammation and age disorders. We also discuss on the mode of action of ozone that, with an hormetic mechanism, appear to be more similar to xenobiotic stress model than a pure pharmacological action. Indeed, our recent work in vivo on patients treated with major autohemo therapy (MAH) demonstrated the increase of Nrf2 level (P
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Possible errors in pain treatment with ozone [abstract]
(2018) Tiron, Stefan
This presentation is made based on (more than) 3000 patient?s experience. The pain treatment with ozone is an excellent one. So ? why don?t we have 100% results? WRONG DIAGNOSIS : - Treatment of an irradiate pain like a local one: every pain in ? Upper limb (with no evident cause): must be treated like an irradiate cervical problem, and treated in cervical region. ? Lower limb ( with no evident cause ) : must be treated like an irradiate lombar problem and treated in lombar region - Traumatical or surgical scars in cervical or abdominal region can explain cervical or lombar pain. The treatment must begin with subcutaneous ozone injections in the pericicatricial region. - Pain given by chronic fatigue syndrome. - Treatment in diseases when the ozone treatment is inefficient ( lombar stenosis, torticolis ? ) TECHNICAL ERRORS: - position of the needle ( paravertebral ) - wrong concentration of ozone
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The efficacy of Ozone Therapy on different types of lumbar disc herniation : Proposal for guidance updates [abstract]
(2018) He, Xiaofeng
Objective. To explore the possible mechanisms of pain relief by ozone therapy in patients with different types of lumbar intervertebral disc protrusion. Methods. The medical records of a total of 250 patients with protrusion of lumbar intervertebral disc (159 males, 91 females, aged 14?85 years) admitted in the South Hospital from January 2009 to June 2014 were retrospectively reviewed. Patients with protrusion of lumbar intervertebral disc were divided into four groups according to T2-weighted magnetic resonance imaging and digital subtraction angiography findings during ozone injection: - type I, fibrous ring rupture without nucleus pulposus protrusion, - type II, fibrous ring rupture with nucleus pulposus protrusion, - type III, non-ruptured fibrous ring without nucleus pulposus protrusion, - type IV, non-ruptured fibrous ring with nucleus pulposus protrusion. Visual analogue scale (VAS) pain scores were used to evaluate treatment efficacy among patients with different types of lumbar intervertebral disc protrusion before surgery, and at 1 week, 1 month, 6 months, and 12 months after surgery. Results. Atrophy of the nucleus pulposus was observed in 63% of type II and IV patients within 1 year after surgery. The VAS scores at 1 week, 1 month, 6 months, and 12 months after surgery decreased by an average of 4.47, 4.41, 4.77, and 4.85 for type I to IV disease, respectively. More specifically, scores of type I patients were decreased by 4.57, 4.72, 4.98, and 4.93, respectively, during the follow-up period. Scores of type II patients were decreased by 4.78, 461, 5.08, and 5; type III cases by 3.72, 377, 3.97, and 4.84, respectively; and type IV cases by 4.24, 4.10, 4.45, and 4.41, respectively. In addition, the postoperative VAS score of 94.4%, 91.6%, 89.6% and 90.8% of patients were decreased by > 25%, i.e., the pain was alleviated, with type I patients demonstrating a pain relief rate of 96.3% during the entire follow-up period, along with 93.5% and 89.8%, and 89.8%, respectively for type II patients, 76.9%, 84.6%, 76.9%, and 87.2%, respectively for type III patients, and 77.6%, 79.6%, 79.6%, and 79.6%, respectively for type IV patients. Conclusion. Ozone therapy is an effective pain-relief therapy for lumbar intervertebral disc protrusion. The degree of pain relief was closely related to rupture of the fibrous ring and protrusion of the nucleus pulposus. Pain relief efficacy was improved in patients with fibrous ring rupture and nucleus pulposus, while the pain relief effects in patients without fibrous ring rupture or nucleus pulposus protrusion were poor.
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How To Combine Ozone Therapies With Other Modalities For Maximum Efficacy [abstract]
(2018) Shottam, Suresh
In order to use Bio-Oxidative Therapies effectively, a small shift in thinking is needed. One needs to shift from Disease Literacy to Healing Literacy. This shift in thinking leads to the inevitable conclusion that: Impaired Oxygen Signaling is the common denominator for all disease. Impaired Oxygen Signaling affects: ? O2 driven energetics ? O2's detergent function ? O2's cellular repair function ? O2's renewal function. It is important to be aware of Oxygen's multiple functions in order to appreciate the importance of the role bio-oxidative therapies play in the reversal of disease conditions. In fact, no treatment of chronic disease can be complete without addressing ALL Oxygen-related issues relevant to a particular patient. What are these oxygen related issues that need to be addressed? There are 4 distinct steps that lead to disease manifestation linked to Oxygen: ? Dysfunctional Oxygen Metabolism ? Acidosis ? Oxidative Coagulation ? Oxidized Lymph. Once the above conditions are understood, it becomes clear that combining bio-oxidative therapies with other modalities can improve the outcome of those modalities. Examples of how to combine therapies to create effective protocols for improved clinical outcome will be discussed. IN SUMMARY, a clear understanding of the Oxygen Model of Disease will enable the practitioner to customize and create innovative combinations for the individual patient.
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Role of ozone Disc Nucleolysis in Herniated intervertebral Disc : The Indian experience [abstract]
(2018) Ghatge, Sharad
Aim. To study the role of ozone disc nucleolysis in herniated intervertebral disc. Materials. We retrospectively analysed consecutives patients undergoing ozone disc nucleolysis. There were Total of 5265 patients with 2740 males and 2525 females. Their Age was ranging from 17 to 84 years. Patients weight was ranging from 36 to 138 kilograms. All the patients had failed conservative management for at least 3weeks. Methods. All the patients were clinically evaluated as per inclusion and exclusion criterions. Pre-treatment Visual Analogue scale (VAS)and Oswestry Disability Index (ODI).All the patients undergone Pre-treatments work up of MRI of the spine.256 patients were undergone Nerve physiological study (EMG,NCV and SSEP). All the procedures were carried out in Cathlab (Siemen's Artis zee) under local anaesthesia. In Lumbar region 3 cc of ozone and in cervical 1cc of ozone-oxygen mixture injected. In Lumbar region additionally 7 cc of ozone-oxygen mixture along with local anaesthetic (Lidocaine) - corticosteroid (Hydrocortisone and triamcinolone) - rheological enzyme (hynidase) injected in epidural space. There were 4406 patients with Lumbar disc herniation and 861 patients with cervical disc herniation. Statistical Analysis was done by SAS online version 2. Results. Outcome was assessed by VAS score, Oswestry Disability Index and modified MacNab scale at 6 month, 12 months and 18 months The mean baseline VAS score was 9 which became 4.9 post ozone disc nucleolysis . Disability Index was 36.13 at baseline which improved to 9.86 post treatment. Success rate was 81% by Modified MacNab outcome scale. Results by all above mentioned the three methods were found to be statistically significant. Conclusion. Ozone disc nucleolysis is highly effective in the treatment of herniated intervertebral disc . It is safe, Durable and cost effective in our series. Our results were slightly better than the published literature. However randomized control trial is recommended to further substantiate our results.
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Ozone in the treatment of musculoskeletal infections [abstract]
(2018) Sundaresh, Srikanth
Ozone, an antibacterial, has a spectrum of action which is bigger than any antibiotic known today. Very few bacteria can resist the onslaught of ozone and this is again dependent on the route of delivery of the ozone- oxygen mixture. Musculoskeletal infections, mainly chronic osteomyelitis and foot ulcers, were taken as criteria for study. Chronic osteomyelitis of the long bones, mainly the tibia was preferred as route of entry into the marrow cavity is easier. Foot ulcers, diabetic or trophic were selected on random basis. Graphic representation based on dimension and pictures taken on regular intervals were the criteria for evidence of healing. All cases were subjected to a short course of antibiotics, based on culture and sensitivity reports, and ozone was added as an adjuvant to see whether ozone hastens recovery and if yes, the quality of recovery, the reduction in financial burden and the requirement of surgery like skin grafts or amputations. All cases were treated using ozone bagging and rectal insufflations on alternate days. It was concluded that ozone not only hastens the healing process, provides antibacterial remedy, but also ensures the healing occurs with good granulation tissue and without the requirement of a skin graft.
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Ozone Therapy in leg ulcers of patients with chronic venous insufficiency [abstract]
(2018) Menéndez Cepero, Silvia
The term chronic venous insufficiency ? CVI (due to a deep vein thrombosis, valvular insufficiency or both) indicates a pathologic condition characterized by alterations of the venous flow and is the main cause in the formation of ulcers in the lower limbs, creating an important socio-medical problem, which finally leads the patient to a total disability for the rest of his/her life. In healthy leg veins, one-way valves allow blood to move only in one direction: upstream towards the heart. This prevents the backward flow of blood, back down the legs. However, in disease leg veins, the valves are enlarged and retracted, in such way, that they become unable to block the retrograde venous flow being the main cause for the appearance of ulcers in the lower limbs. Taking into account the different therapeutic effects of ozone as [1,2]: improvement of oxygen metabolism and blood rheologic properties, stimulation of the antioxidant defense system achieving the cell redox balance, modulation of the immunological system and nitric oxide, as well as its great germicide power, among others, the aim of this study was to evaluate the efficacy of ozone therapy on the healing process of chronic ulcers of the lower limb in comparison with conventional treatment. A controlled and randomized phase III clinical trial was performed in 90 hospitalized patients with ulcers (over 2 years of evolution, with a diameter of no less than 5 cm) of the lower limbs due to CVI [3]. Efficacy was evaluated according to the least time of hospital stay, which was the necessary time for the lesions to heal or when they were aseptic or their granulation tissue was ready for skin graft. In the cases where the patient did not want to be skin grafted, he/she was discharged and continued treatment at home with topic OLEOZON® (sunflower ozonated oil). The sample was divided at random into 3 groups of 30 patients each: 1-Control group (conventional treatment): venous repose (leg elevation), hyposodic diet, analgesics, daily cure with saline solution and fomentation with antiseptic solutions, several times per day. 2-Ozone group (M-AHT): venous repose (leg elevation), hyposodic diet, analgesics and local ozone treatment (bagging) and topical OLEOZON®, once per day, combining with M-AHT (3 times per week), up to 10 sessions (50 mg/L and 50 mL in 100 mL of blood). 3-Ozone group (Rectal): As M-AHT group but using rectal ozone application up to 20 sessions, once per day (50 mg/L and 200 L). No systemic or local antibiotics were used in the study. Results indicated an average length hospital stay of (53.1 ± 13.9) d for the control group and of (31.5 ± 6.7) d for both ozone group, with significant differences between control and ozone groups. Therefore, hospital stay was reduced for patients with ulcers in the lower limbs treated by ozone therapy, with the subsequent economic saving. No significant differences were observed between the two ozone groups in length hospital stay. No adverse reactions were seen. Ozone therapy can be considered as another treatment within the therapeutical supply for this condition, which could provide a fast rehabilitation for patients as well as their incorporation to a useful life.
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Percutaneous direct ozone injection in solid tumours [abstract]
(2018) Saxena, Praveen K.
This lecture defines the scope of Direct Ozone Injection into solid tumors, and introduces attendees to the ways in which Direct Ozone can be given under ULTRASOUND guidance (USG). Percutaneous USG guided Ozone injection is an exciting approach to destroying inoperable primary tumors or metastases in the liver in the treatment of hepatocellular (HCC), fewer than 40% of patients are candidates for surgery, and the rate of recurrence after curative surgery is high. Percutaneous techniques like Ozone Absolute alcohol & RFA are widely used for metastatic and small primary tumors. It serves as a bridge for transplant candidates, especially in relation to small primary lesions. Percutaneous Ozone is a minimally invasive, repeatable procedure with few complications. It is performed under Ultrasound guidance. Ozone results in a higher rate of complete necrosis and requires fewer treatment sessions than percutaneous ethanol injection (PEI). Long-term survival rates are also better. Our series of 4 patients compared well than the patients treated with Trans catheter arterial chemoembolization (TACE) Cholangiocarcinoma?s with obstructive biliary system responded well with direct USG Guided Ozone Injections.
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Integration of Ozone Therapy for head and neck infective and chronic disease [abstract]
(2018) Mollica, Philip
Introduction. Treatment and management of complex chronic disease states within the head and neck have traditionally been treated within the scope and philosophy of allopathic based dental/medical model. Success is therapeutically based upon three stanchions symptomology, pharmacology and surgical intervention. As with the successes of any therapeutic model some complications are possible. Symptomatic treatment does not address the root causality of the disease process. In addition, the patient can experience pharmaceutical side effects and post-surgical compilations such as infection and impaired healing processes. Ozone therapy as part of an Integrative Biologic Dental Medicine model has allowed for a paradigm shift in thinking and approach to the ever-growing problems of therapy resistant infection, aging population and chronic long term aliments [1-3]. The management of acute and chronic infective disease is a critical factor in the overall health and wellness of patients. The head and neck are principle areas of infective disease. Primary contributors to this issue are infections of odontogenic and/or osteogenic origins [4]. Ozone therapy has become one of the principle therapeutic modalities utilized in Integrative Biologic Dental Medicine ?IBDM'. The objective of this presentation will be to explain and demonstrate specifically how ozone therapy is utilized in dental medicine. Through specific micro-dosing and anatomic placement of ozone enhanced healing processes can occur [5]. Reparative osteogenesis is one corner stone in the restoration and maintenance of human jaw integrity [6]. Case presentations will be the demonstrative educational model by which comprehensive head and neck infection remediation and tissue repair occur for patients. Material and methods. In 2011, Professor Olga Sonia Leon Fernandez, University of Havana, Cuba, presented at the European Ozone Congress what she calls ?Fundamental Scientific facts about Medical Ozone? [7]. This information reinforced the previous work done by Dr. Renate Viebahn-Hansler and Dr. Velio Bocci. These fundamental facts are significant in that they can directly influence biologic systems on multiple levels in a positive way to support and enhance the patient's healing process [1,7,8]. These scientific facts include the following: 1 Disinfection properties: microbicidal effect (bactericide, fungicide, virostatic, parasiticidal) 2 Wound cleaning 3 Enhance wound healing 4 Activation of red blood cell metabolism with improved oxygen release, increase in ATP levels 5 Activation of immunocompetent cells and release of cytokines such as interferones and interleukins. 6 Modulation of the immune system. 7 Increase in antioxidant capacity through activation of cellular antioxidants ? (superoxide dismutase, catalase) 8 Anti-inflammatory effect 9 Endothelium cell increased release of nitric oxide 10 Equilibration of Redox Potential 11 Release of stem cells, autacoids and growth factors Taking into consideration the multitude of positive therapeutic biologic effects ozone therapy has, one has to wonder if it is possible to support and enhance that process and ultimately improve the patient's outcome [9]. Development and incorporation of an educational and clinical model is a critical cornerstone for successful patient outcomes. Based upon the thesis of result based dental medicine, Integrative Biologic Dental Medicine was created. As a result guidelines based upon the low-dose concept of oxygen/ozone therapy can be integrated into the daily practice of dental medicine. Conclusions. Integration of oxygen/ozone therapy into dental medicine is a paradigm shift for patient enhanced outcomes. Comprehensive understanding of the proper application and integration of this therapeutic modality is critical. This can only be achieved through proper training of the practitioner based upon a sound educational and philosophical model. Integrative Biologic Dental Medicine is an established educational and philosophical model that recognizes and welcomes emerging and established therapeutic modalities such as oxygen/ozone therapy.