Log In 
Language Journal of Clinical and Experimental Dentistry. 2025. Vol. 17, no. 01
Permanent URI for this collection
Browse
Recent Submissions
- Oral manifestations of syphilis: a report of six cases(Medicina Oral S.L., 2025) Bevervanso, MW.; Soto, VC.; Ranthum, LK.; Rosa, HH.; Campagnoli, EB.; Bortoluzzi, MC.Syphilis is a highly contagious infectious disease primarily transmitted through sexual contact, caused by Treponema pallidum, an anaerobic gram-negative bacterium. Oral manifestations are significant, with the oral cavity often being the first site to exhibit symptoms. This study aims to present the clinical manifestations of oral syphilis through a six cases diagnosed in a dental setting. The results reveal that oral syphilis lesions predominantly affect areas such as the tongue, gingiva, and palates, presenting as mucous plaques, ulcerations, and erythematous regions. Painful oral sores and cervical lymphadenopathy were common, with symptoms varying in duration from 3 weeks to 3 months. All cases were classified as secondary syphilis and were confirmed through serological tests.
- Oral neurovascular hamartoma: an independent entity not associated to rhabdoid tumors(Medicina Oral S.L., 2025) Guerrero-Martín, M.; García-Serrano, G.; Nájera-Botello, L.; González-Jiménez, A.; Sagüillo-Pallares, K.; Pezzi-Rodríguez, M.; Acero-Sanz, J.Oral cavity neurovascular hamartomas are extremely rare, with unknown prevalence, possibly due to their rarity, unrecognition or under-report. We describe a 6-year-old female patient with this uncommon lesion and review existing literature.The patient presented with asymptomatic papular lesions, which increased in size and number since birth. First, one of the papular lesions on the lower lip was excised for histopathologic study, revealing the unexpected diagnosis.Oral neurovascular hamartomas are unusual and challenging lesions to diagnose. Even though their benign nature, the need of differential diagnosis with other oral lesions makes necessary their histopathological study and confirmation.Even oral neurovascular hamartoma is an uncommon entity, surgeons and oral pathologist should be aware of this entity in order to distinguish it from other lesions. Besides, it is not clearly related to rhabdoid tumors as other authors have stablished previously, being an independent entity with great prognosis for the patient.
- Effectiveness of mouthwashes to reduce the SARS-COV-2 load in saliva of adults with diagnosis of COVID-19: systematic review and meta-analysis(Medicina Oral S.L., 2025) Espejo-Carrera, RE.; Asmat-Abanto, AS.; Honores, MJ.; Alvarado, JA.COVID-19 still represents a threat to public health. In this sense, antiseptic mouthwashes have been suggested to reduce cross-contamination and community transmission.This systematic review and meta-analysis aimed to synthesize the evidence on the effectiveness of povidone-iodine (PVP-I), cetylpyridinium chloride (CPC) and chlorhexidine (CHX) mouthwashes in reducing SARS-COV-2 viral load in the saliva of adults diagnosed with COVID-19. After the systematic search in five electronic databases, 16 clinical trials published until June 2023 were analyzed. Of these, 6 were included in the meta-analysis.The standardized mean difference (SMD) was reported with its corresponding 95% confidence intervals (95%CI). An overall SMD of 0.51 (95%CI: -0.29 to 1.32; I² = 46.0%; p = 0.047) was found. For CPC, the combined effect found in the studies was not significant (SMD = -0.07; 95%CI: -0.42 to 0.28; I² = 0.0%; p = 0.373); the same occurred for CHX (SMD = 0.50; 95%CI: -43.32 to 44.32; I² = 0.0%; p = 1.000). However, PVP-I showed a more consistent profile with a significant combined effect (SMD = 4.15; 95%CI: 2.11 to 6.18) and negligible heterogeneity (I² = 0.0%; p = 0.908).The findings indicate a non-significant effect of mouthwashes on reducing viral load when all types were evaluated together. Separately, only PVP-I showed a significant reduction in viral load with a low level of certainty of evidence, while for CPC and CHX the reduction was not significant, with a low and very low level of certainty of evidence, respectively.
- Influence of anterior open bite on oral health-related quality of life. A systematic review(Medicina Oral S.L., 2025) Rodriguez-Huaringa, JE.; Vargas-Mori, GX.; Arriola-Guillén, LE.Anterior open bite is a malocclusion caused by genetic and environmental causes that affect esthetics, occlusion, and speech, impacting the quality of life in children, adolescents, and adults. However, to date, no systematic review has analyzed the influence of anterior open bite (AOB) on oral health-related quality of life.This systematic review conducted a comprehensive search in the MEDLINE (via PubMed), EBSCO, SCOPUS, and LILACS databases until September 30, 2023. A total of 321 articles were identified across these databases. After applying the selection criteria, 13 articles were selected for full-text evaluation. Ultimately, only six studies, all cross-sectional, were included in the review. The Newcastle-Ottawa Scale was utilized to assess the risk of bias in these studies.Six studies have found that AOB affects quality of life. In adults, it has a greater impact on women, especially on psychological and social well-being. In children, negative effects are observed in symptoms, function, and psychological aspects, with poor outcomes. One study found no significant differences in quality of life in children with AOB.The review indicates that AOB (anterior open bite) significantly impacts quality of life, particularly in psychological and functional areas such as speech, eating, and smiling. This information is essential for both orthodontists and patients. While most studies show moderate bias, further well-designed research is recommended.
- Determination of the legal age of majority in Spain and in the European Union. Current situation(Medicina Oral S.L., 2025) Miravé, Araceli; Abecasis, P.Migration brings numerous challenges, especially when undocumented minors arrive in large numbers. Age determination is essential in providing minors with legal protection while preventing abuse of systems designed for their welfare. Traditional methods, such as hand radiographs and orthopantomography, have faced criticism for their lack of precision and reliance on outdated standards. This study evaluates contemporary approaches for determining age, emphasizing the need for updated protocols.The study examines the legal framework in Spain regarding age determination of undocumented migrants, emphasizing the phased process involving physical examinations, dental radiographs, and CT scans of the clavicle. The challenges of using traditional methods, including variations in bone maturation across ethnic groups, are addressed.Analysis revealed limitations in traditional methods such as the Greulich and Pyle atlas and orthopantomography. These methods tend to overestimate age in certain populations and lack applicability in diverse ethnic contexts. CT of the clavicle emerged as a more reliable tool for late adolescents, despite its higher radiation dose.The findings underscore the importance of adapting age estimation methods to diverse populations and leveraging advanced imaging technologies. Radiological techniques must be used judiciously to balance accuracy and ethical considerations. Updating protocols to include multidisciplinary approaches and integrating new technologies can significantly improve outcomes.Modernizing age determination practices is crucial to align with contemporary needs and protect the rights of migrants. Establishing detailed and specific protocols tailored to diverse populations will ensure both scientific reliability and humanitarian principles in forensic and legal applications.
- Glandular odontogenic cyst: comprehensive clinicopathological and immunohistochemical characterization(Medicina Oral S.L., 2025) Lonni, N.; Barbosa, B.; Souza, L.; Couto–Vieira, D.; Rivero, E.; Gondak, R.; Albuquerque-Júnior, RL.The glandular odontogenic cyst (GOC) is a rare aggressive odontogenic lesion, whose diagnosis can be challenging due to the overlap of microscopic findings with other lesions of the jaws. However, the main histopathological and immunohistochemical criteria for establishing the proper diagnosis have not yet been universally accepted. This study aimed to report a series of seven cases of Glandular Odontogenic Cyst, with emphasis on the comprehensive clinicopathological and immunohistochemical characterization.Clinicopathologic data were gathered from medical records and histological slides obtained from paraffin-embedded samples of GOC. Additionally, the slides were subjected to immunohistochemical staining for cytokeratins (CK) 5, 7, 8/18, 19 and a cytokeratin pool (pan-CK), as well as for p63, α-SMA, and Ki67.GOC occurred predominantly in females (71.42%), with a mean age of 48.28 ± 17.67 years, affecting the anterior region of the mandible (42.85%). Radiologically, the lesions were mostly unilocular (71.42%), showing buccal cortical bone expansion (85,71%). The main histological features included intraepithelial duct-like and crypt formations, apocrine metaplasia, and epithelial thickenings of the cystic lining. All lesions were strongly positive for pan-CK, CK5, and CK19, and moderately positive for p63. Ki67 was expressed in less than 5% of epithelial cells.Although many histopathological features of GOC have been reported, the presence of duct-like structures and crypts, and focal epithelial thickenings are likely the main diagnostic criteria of this lesion. Furthermore, the correlation of these features with immunohistochemical positivity for pan-CK, CK5, Ck19, and p63 may help establish the proper differential diagnosis of this odontogenic cyst.
- Accuracy of apical limit control during retreatment provided by hybrid electronic foraminal locators: a micro-CT study(Medicina Oral S.L., 2025) Frota, LM.; de Oliveira-Neto, RS.; Limoeiro, AG.; Alcalde, MP.; Vivan, RR.; Duarte, MA.; Bernardes, RA.; Vasconcelos, BC.This study investigated the accuracy and reliability of apical limit control in endodontic retreatment using hybrid endodontic motors.Thirty-six mesial canals of mandibular molars were accessed, and their apical foramina (AF) were standardized to 200 µm. Chemical-mechanical preparation was performed with WaveOne Gold instruments (#20/.07), followed by obturation with gutta-percha and AH Plus cement. After initial preparation, the teeth were divided into three groups (n = 12): Root ZX II (RZX), VDW Gold (VDW) and Tri Auto ZX2 (TRZX), all in rotary kinematics and with AF as the limit (0.0). Exposure was performed in the crown-down direction with ProTaper retreatment instruments using 2.5% NaOCl as an irrigation solution. Before using the instruments, the apexes of the teeth were immersed in alginate. With the auto-stop function activated, the hybrid instruments were calibrated to stop rotating when the desired apical limit was reached. The last instrument was fixed in the canal and a micro-computed tomography scan was performed to determine the distance between the instrument tip and the AF. Data were analyzed using the Kruskal-Wallis and Dunn tests (P<0.05).No significant differences were found between the RZX (0.10 mm), Gold (0.13 mm) and TRZX (0.27 mm) devices; accuracy ranged from 91.70% (RZX and VDW) to 63.63% (TRZX). TRZX had the highest number of readings besides AF.It was concluded that all devices studied were efficient in maintaining the apical limit of instrumentation during endodontic retreatment when taken to the AF.
- Influence of indirect air-cooling on the variation in intrapulpal temperature during rapid high-intensity light-curing using a bulk-fill resin composite(Medicina Oral S.L., 2025) Miranda, SB.; Mendes, VC.; Leal, Cd.; Falson, LA.; Silva, Gd.; de Andrade, AK.; Lins, RB.; Montes, MA.This study investigated the effect of indirect air-cooling on the variation in intrapulpal temperature (ΔT) during different light-curing protocols of bulk-fill resin composites in molars with class V cavities.A nonretentive class V cavity was prepared in a maxillary molar. The intrapulpal temperature changes with and without indirect air-cooling were recorded using a type K thermocouple. The cavity was restored with bulk-fill resin composites: Tetric PowerFlow (Ivoclar, Vivadent) and Filtek Bulk-Fill Flow (3 M, ESPE). The tooth was exposed to different light-curing protocols (n=5) using the Valo Grand light-curing unit: (i) high-intensity light-curing protocol of 3200 mW/cm² (3 and 6 s) and (ii) moderate-intensity light-curing protocol of 1000 mW/cm² (10 and 20 s). The ΔT data were subjected to two-way ANOVA, followed by the Bonferroni post hoc test.A significant increase in temperature was observed with the use of the high-intensity light-curing resin composite without indirect air-cooling. In addition, the application of air-cooling significantly decreased the temperature in all the groups except for the Tetric PowerFlow bulk-fill resin composite at 3 s of light-curing.Indirect air-cooling resulted in a lower increase in intrapulpal temperature during the light-curing of bulk-fill resin composites, making it an effective alternative technique for controlling the temperature rise in class V restorations with 1 mm of remaining dentin.
- Fluoride-Induced Microhardness Changes in Resin-Modified Glass Ionomer Cements: a comparative study(Medicina Oral S.L., 2025) Rufasto-Goche, KS.; Cerro-Olivares, E.; San Martín-Hilario, N.; Santander-Rengifo, FM.; Murillo-Carrasco, AG.; Lizarbe-Castro, MV.Resin-modified glass ionomer cement (RM-GIC) is widely used in clinical dental procedures as a restorative material due to its chemical composition. It is known for its strong adhesion to dental structures and its fluoride content. However, fluoride in RM-GIC is insufficient for preventing the formation of carious lesions, making the use of fluoride gel and varnish necessary as preventive strategies. Nevertheless, there may be adverse interactions between RM-GIC and fluoride, which could compromise the properties of these restorative materials.Therefore, it is crucial to understand the physicochemical and biological properties of the products used in dental treatments. This experimental study aimed to evaluate the effect of the following fluorides: 2% neutral sodium fluoride (NaF), 1.23% acidulated phosphate fluoride (APF), and 0.1% fluoride varnish (7700 ppm F) in the mi-cro-hardness of the RM-GIC.Using GC Fuji II LC-A2, 80 RM-GIC discs measuring 6cm x 4cm were made and immersed in artificial saliva for seven days. Then, the discs were washed, dried, and randomly divided into four groups, and the initial surface microhardness was measured. After that, the discs were immersed in the three fluorides to measure the microhardness for a second time. The average value of the surface microhardness of the RM-GIC in the final phase (exposure to fluorides) of the three experimental study groups is lower than the initial phase (non-exposure to fluorides).There was a significant decrease in the microhardness of the ionomer with the application of the three fluorides (p= 3.6x10-12). Particularly, the treatment with 1.23% acidulated phosphate fluoride demonstrated higher variation than 2% neutral sodium fluoride (p=0.0063) or 0.1% fluoride varnish (p=2.2x10-5).2% neutral sodium fluoride, 1.23% acidulated phosphate fluoride, and 0.1% fluoride varnish (7700 ppm F) applied to RM-GIC decreases surface microhardness.
- Color characteristics of various computerized machinable ceramics veneered to yttria-stabilized tetragonal zirconia polycrystalline upon different hybridized techniques(Medicina Oral S.L., 2025) Juntavee, N.; Juntavee, A.; Tangsatchatham, S.Hybridization technique impacted color of ceramic veneered zirconia. This study examined color characteristics of different ceramics veneered zirconia upon different hybridized techniques.120 zirconia specimens (0.8 mm thickness, 12 mm diameter) were prepared from 3-yttria-stabilized tetragonal zirconia polycrystalline and unintentionally veneered with Vitabloc Mark-II (Vm), IPS e.max CAD (Em), Vita-Suprinity (Vs), and Celtra-Duo (Cd), by CAD-bonded (Cb) versus CAD-fused (Cf) hybridization (n=15/group). CIE-L*a*b* color characteristics were determined for translucency parameter (TP), contrast ratio (CR), opalescence parameter (OP), and color difference (ΔEdiff). Microstructures were investigated with SEM and XRD. Analysis of Variance and Bonferroni comparisons were determined for significant differences (p<0.05).TP and OP were significantly higher, but lower CR and ΔEdiff for Vm and Em than Cd and VS. Cf hybridized technique significantly decreased TP and OP but increased CR and ΔEdiff than Cb, which amplified color alteration. Better TP and OP, with less CR and ΔEdiff, were achieved for zirconia veneering with either Vm or Em, compared to Vs or Cd, whether hybridized with Cb or Cf technique.Different veneering ceramics and hybridized techniques significantly altered color characteristics of ceramic veneered zirconia. Zirconia veneering with either Vm or Em appeared to produce better translucence and opalescence, with less contrast and color alteration than veneering with either Vs or Cd. CAD-fused decreased translucency, opalescence, and intensified color alteration due to t→m transformation. Nevertheless, the color alteration of ceramics veneered zirconia still rendered an acceptable limit, except for both Vs and Cd upon Cf hybridization.
- The effect of replacing dental needles between subsequent inferior alveolar nerve blocks on pain and trismus – a double blinded, randomised split-mouth study(Medicina Oral S.L., 2025) Skapetis, T.; Idowu, AO.; Fernando, TA.; Marvel, G.; Mehta, KV.; Verzosa, HInferior alveolar Nerve Blocks are widely used in dental practice for achieving anaesthesia in the mandibular teeth. It is widely accepted that in order for this type of injection to be effective, the needle needs to penetrate a substantial depth of soft tissues as well as make contact with bone. This routinely leads to both blunting and barbing of the needle tip suggesting that a needle change is preferable for any subsequent injection as this will result in less tissue damage and pain for patient’s. The study aimed to verify whether a change in needle affected measures of pain and trismus.This was a prospective, single center, double blinded (both clinician and participant), randomized, split-mouth study conducted in a large dental hospital and teaching facility. Participants were screened for factors that might alter their head pain sensation and participated in 2 clinical visits. In the first visit 2 needle insertions either with/without needle change were performed without anaesthetic as per an IANB injection. A survey instrument was used to capture several dimensions of pain both immediately after the visit as well as 48-72 hours later. This method was repeated on a second visit on the opposite mandibular quadrant after a washout period of at least 2 weeks. Paired t-Test’s were performed at the 2 time points.Significance was only demonstrated in one of 10 sensory and 12 emotional pain descriptors during one of the 2 time points of measurement. Similarly, VAS mean pain scores and a measure of trismus were not affected by needle change.This study was able to demonstrate that a change in needle between subsequent IANB’s does not affect self-reported measures of pain nor trismus.
- Evaluation of factors associated with fear and anxiety in the orthodontic treatment of adult patients(Medicina Oral S.L., 2025) Serrat-Lacasta, L.; de la Cruz-Vigo, S.; Leonelli, M.Despite the technological advances made in dentistry, anxiety and fear of pain due to dental treatment are still common. Most patients in a dental clinic suffer some symptoms of anxiety, which can appear at different times. The objective is to know the degree of anxiety and the factors associated with this anxiety during orthodontic treatment.180 adult patients who started orthodontic treatment were selected and a questionnaire was administered at the beginning and after six months of treatment. The SDAI anxiety scale was used to determine the degree of anxiety and its own questionnaire to determine its relationship with the different factors of orthodontic treatment.When performing descriptive and inferential statistics, it is obtained that 72% of patients at the beginning of orthodontic treatment present a certain degree of anxiety. Through individual logistic regression using anxiety as a response and each of the demographic variables at six months as predictors, it is obtained that gender(OR=3.15) and occupation(OR=3.11) are the two significant predictors (P<0, 05). Using Fisher’s exact test of independence, the additional questions are related to the demographic variables and anxiety, obtaining a value of P<0.05 in 27(of 114) non-independent relationships between the additional questions and the demographic/anxiety variables.38%of patients who begin orthodontic treatment have high anxiety, but after 6 months this anxiety drops to 22%. Women and patients with active work are the most likely to present more anxiety at 6 months. The biggest concerns at the beginning of treatment are: Changes in appearance(Q15),Eating(Q18),Appliance loss(Q19),Hygiene(Q24),Tooth loss(Q25),Extend treatment(Q26),Expectations(Q27) and Retention(Q28).Of these eight, only three continue to worry patients after six months: appliances loss(Q19),Hygiene(Q24) and Tooth Loss(Q25).At the beginning of treatment there are two questions that do not worry: Enter alone(Q10) and take medications(Q21).Four more are added after six months: Embarrassment(Q16),Getting used to it(Q17),Periodic visits(Q22) and Emergencies(Q23).
- Do preheated composite resins provide better cementation results for indirect restorations? A Systematic Review(Medicina Oral S.L., 2025) Souza, JP.; Piacenza, LT.; Mazaro, JV.; Moreno, AL.; Moreno, Nerea; dos Santos, DM.; Goiato, MC.The article addresses the use of preheated composite resins as cementation agents in indirect restorations, highlighting the importance of these materials in the adhesion between the restoration and the dental substrate. Cementation agents are crucial for the overall strength of restorations, and research indicates that resins with higher inorganic filler content may enhance the strength of ceramic restorations.The study was conducted as a systematic review, following PRISMA guidelines, and analyzed bond strength, physicochemical properties, and color variations. After a search in various databases, nine studies were included in the analysis.The results suggest that while preheated composites may have some advantages, their mechanical properties and the thickness of the cementation layer are not superior to those of traditional resin cements.The article concludes that the adoption of these composites as cementation agents results in modest improvements, and caution is needed when considering their clinical application.
- Influence of lip volume enhancement with hyaluronic acid in-filtrations on lip Imprints(Medicina Oral S.L., 2025) Luis-Sanchez, L.; Torres-Lagares, D.; Vazquez-Pachón, C.; Hernandez-Pachecho, E.; Ruiz-de-Leon-Hernandez, G.; Serrera-Figallo, MA.; Gutierrez-Perez, JL.; Baus-Dominguez, M.Cheiloscopy, as a method of forensic identification, maintains its currency in legal and forensic dentistry. The increase in aesthetic lip filler treatments could influence lip prints. This aspect has not yet been studied to the research team’s knowledge. Objective: This study aims to evaluate the possible modification of lip imprints after hyaluronic acid infiltration for volume augmentation in this location.A descriptive, non-experimental study was carried out in patients with lip augmentation using hyaluronic acid infiltration (32 patients). Pre-infiltration data were collected (age, sex, lip traces, and lip characteristics), and data on the infiltration performed (volume used, points, and infiltration technique). During five visits, the evolution of the lip print and lip characteristics was monitored six months after the initial infiltration.Applying the Suzuki and Tsushihashi classification, 92.9% of the cases studied showed differences concerning the preoperative situation.From the data of the present study, we can affirm that, without generating critical changes, lip hyaluronic acid infiltration modifies some characteristics of the lip print, which should be known and considered when using cheyloscopy as a forensic identification tool.
