The first enantioselective alkylation of 5‐aminopyrazoles is described with good results. The organocatalytic alkylation of 5‐aminopyrazoles have been accomplished using benzoxathiazine 2,2‐dioxides as electrophiles and a bifunctional squaramide organocatalyst.
Carceller-Ferrer, Laura González del Campo, Aleix Vila Descals, Carlos Blay Llinares, Gonzalo Muñoz, M. Carmen Pedro, José Ramón 2020 Organocatalytic Enantioselective Aminoalkylation of 5-Aminopyrazole Derivatives with Cyclic Imines European Journal of Organic Chemistry 2020 48 7450 7454
