Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma

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2014
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Abstract
The activity of Nitric Oxide Synthase 2 (NOS2) was found in oral squamous cell carcinomas (OSCC) but not in normal mucosa. Molecular changes associated to early carcinogenesis have been found in mucosa near carcino - mas, which is considered a model to study field cancerization. The aim of the present study is to analyze NOS2 expression at the histologically normal margins of OSCC. Study Design: Eleven biopsy specimens of OSCC containing histologically normal margins (HNM) were ana - lyzed. Ten biopsies of normal oral mucosa were used as controls. The activity of NOS2 was determined by im - munohistochemistry. Salivary nitrate and nitrite as well as tobacco and alcohol consumption were also analyzed. The Chi-squared test was applied. Results: Six out of the eleven HNM from carcinoma samples showed positive NOS2 activity whereas all the control group samples yielded negative ( p =0.005). No statistically significant association between enzyme expression and tobacco and/or alcohol consumption and salivary nitrate and nitrite was found. Conclusions: NOS2 expression would be an additional evidence of alterations that may occur in a state of field cancerization before the appearance of potentially malignant morphological changes.
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Morelatto, Rosana ; Itoiz, María-Elina ; Guiñazú, Natalia ; Piccini, Daniel ; Gea, Susana ; López de Blanc, Silvia Adriana. Nitric oxide synthase 2 (NOS2) expression in histologically normal margins of oral squamous cell carcinoma. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2014, Vol. 19, No. 3: 242-247