Novel Examples of the N-Methyl Effect on Cyclizations of N-BOC Derivatives of Amino Alcohols. A Theoretical Study
Loading...
Publication Date
Reading Date
Journal Title
Journal ISSN
Volume Title
Directors
Keywords
Abstract
New examples of the N-methyl effect on the cyclisation of N-tert-butoxycarbonyl derivatives of amino alcohols are reported. Ab initio studies for the displacement step with formation of the five-membered heterocycle indicate that the increase of the nucleophile character of the carbonyl oxygen of the carbamate group with the N-methyl substitution is responsible for the acceleration of the cyclisation step.
Bibliographic reference
Hamdach, A., El Hadrami, E. M., Testa, M. L., Gil, S., Zaballos-García, E., Sepúlveda-Arques, J., Arroyo, P., & Domingo, L. R. (2004). Novel examples of the N-methyl effect on cyclisations of N-Boc derivatives of amino alcohols. A theoretical study. En Tetrahedron (Vol. 60, Issue 52, pp. 12067-12073). Elsevier BV. https://doi.org/10.1016/j.tet.2004.10.038
Publisher
Elsevier BV
Signature
Collections:
Other versions
Metrics
Export
Cite
Citations
0 citations in
| Other documents of authorship
Share
Document Viewer
Select a file:
Reload