Response to "Comment on Maternal Perfluoroalkyl Substances, Thyroid Hormones, and DIO Genes: A Spanish Cross-sectional Study: Predictability of Multiple Imputations for Large Amounts of Missing Data"

The main objective of our study was to investigate the possible association between levels of first-trimester maternal perfluoroalkyl substances (PFASs) and thyroid hormones (THs), as well as to explore the potential role played by polymorphisms in the iodothyronine deiodinase 1 (DIO1) and 2 (DIO2) genes in this association. To this end, we performed multivariate regression analyses between PFASs and THs and, furthermore, we added the interaction term PFAS-genotypes to these models. With the aim of assessing the robustness of our results, we also presented several sensitivity analyses in the Supporting Information.