Efectos de la maprotilina sobre la evitacion inhibidora en ratones machos y hembras

The effects of acute and chronic administration of maprotiline (2.5, 5, 10, 15, 20 or 25 mg/kg, intraperitoneally) were assesed on inhibitory avoidance in male and female mice. Acute administration of maprotiline before training impaired performance (i.e. produced shorter latencies) in the test phase at doses of 5, 20 and 25 mg/kg. This effect was stronger in female than in male subjects. Chronic administration for 21 days (interrupted 24 h before training) aldo shortened latncies in the test at doses of 5 and 20 mg/kg in male mice of the OF-1 strain, but the dose tested (25 mg/kg) in CD-1 male and female mice did not show any effect. The effect og maprotiline on activity, anxiety, and analgesia war also studied. Acute administration of 20 and 25 mag/kg of maprotiline reduced the activity and showed an analgesic effect both in male and female animals. The 25 mg/kg dose showed ans axiolytic effect in female. The drug had nost significant effect on activity or anxiety after chronic administration. The state-dependent learning phenomenon was studied using the 25 mg/kg dose. The results of this experiment showed that memorization deficit and performance facilitation seem to be involved. Taken together, these results indicate that acute doses of maprotiline produce anterograde amnesia and, at the highest doses, reduce locomotor activity, produces analgesia, and have anxiolytic effects. Chronic administration of the drug, unless at the highest dose, also produce an amnesic effect. The chronic administration of the highest dose leads to tolerance to the effects of maprotiline on anxiety and activity.