Objective: The aim of this study was to analyze the immunohistochemical expression of Skp2 protein in 38 oral nevi and 11 primary oral melanomas. Study Design: Expression of this ubiquitin protein was evaluated by immunohistochemistry in 49 oral melano - cytic lesions, including 38 intramucosal nevi and 11 primary oral melanomas. The labeling index (LI) was as - sessed considering the percentage of cells expressing nuclear positivity out of the total number of cells, counting 1000 cells per slide. Results: Skp2 protein was rarely expressed in intramucosal nevi, in contrast to oral melanomas, which showed high levels of this protein. Conclusion: These results indicate that Skp2 protein may play a role in the development and progression of oral melanomas, and it also could be useful as an immunohistochemical marker for differential diagnosis of oral be - nign and malignant melanocytic lesions.
Benevenuto de Andrade, Bruno Augusto ; León, Jorge Esquiche ; Carlos, Roman ; Azañero, Wilson Delgado ; Mosqueda Taylor, Adalberto ; Almeida, Oslei Paes de. Immunohistochemical expression of Skp2 protein in oral nevi and melanoma. En: Medicina oral, patología oral y cirugía bucal. Ed inglesa, 2013, Vol. 18, No. 3: 388-391
