Aloinjerto de matriz ósea descalcificada versus injerto autólogo en la reparación de defectos óseos segmentarios masivos. : Estudio experimental

The regenerative capacity of decalcified allogenic matrix was compared with that of autologous bone graft for treatment of osteoperiosteal defects, 4-5 cm in length, experimentally induced in the sheep femoral diaphysis. Eighteen skeletally matur e shee p wer e use d in this investigation. In 8 animals, the reconstructio n of the diaphyseal defect wa s performed using small fragments of decalcified allogeni c bone matrix. In othe r 6 animals, the defect wa s refilled with corticoespongious autologous bone graft in chips. Bone stabilization was achieved by means of an external fixator. After radiologic and histologic assessments, the results wer e compared with a control group including 4 animals with the same diaphyseal defect but without any attempt of reconstruction. Autologous bone graft was found to be more efficient than decalcified allogenic bone matrix for treatment of large segmental bone defects. An osteogeni c activity leading to the complete repair and consolidation of the defect wa s only detected in 1 of the animals treated with allogenic bone matrix. On the contrary, no failures in the incorporation and consolidation of grafts wer e observed in thos e animals treated with autologous bone chips.