Strain-Promoted Cycloaddition of Cyclopropenes with o-Quinones: A Rapid Click Reaction
Novel click reactions are of continued interest in fields as diverse as bio-conjugation, polymer science and surface chemistry. Qualification as a proper 'click' reaction requires stringent criteria, including fast kinetics and high conversion, to be met. Herein, we report a novel strain-promoted cycloaddition between cyclopropenes and o-quinones in solution and on a surface. We demonstrate the 'click character' of the reaction in solution and on surfaces for both monolayer and polymer brush functionalization.
Gahtory, Digvijay Sen, Rickdeb Kuzmyn, Andriy R. Escorihuela Fuentes, Jorge Zuilhof, Han 2018 Strain-Promoted Cycloaddition of Cyclopropenes with o-Quinones: A Rapid Click Reaction Angewandte Chemie 57 32 10118 10122