Clear cell variant of calcifying epithelial odontogenic tumor: case report with immunohistochemical findings

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2015
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Abstract
Calcifying epithelial odontogenic tumor (CEOT) is a rare benign odontogenic neoplasm, locally aggressive, characterized by sheets and nests of polyhedral epithelial cells exhibiting eosinophilic cytoplasm or less often clear cytoplasm. Additional features include nuclear pleomorphism without mitotic activity, concentric calcifications, and deposits of amyloid. Herein, we present an additional example of clear cell variant of CEOT occurring in a 25-year-old female. Microscopically, the tumor consisted on proliferation of epithelial cells with eosinophilic, clear vacuolated cytoplasm interspersed with focal areas of amyloid deposition. Tumor cells were immunopositive for AE1/AE3, CK14, CK19, ß-catenin, CD138, and p63.
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Turatti, Eveline ; Brasil, Juviano ; Andrade, Bruno Augusto Benevenuto de ; Romañach, Mário José ; Almeida, Oslei Paes de. Clear cell variant of calcifying epithelial odontogenic tumor: case report with immunohistochemical findings. En: Journal of Clinical and Experimental Dentistry, 2015, Vol. 7, No. 1: 163-166