A clinical staging model for bipolar disorder : longitudinal approach.
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A clinical staging model for bipolar disorder : longitudinal approach.

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A clinical staging model for bipolar disorder : longitudinal approach.

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dc.contributor.author Fuente Tomás, Lorena de la
dc.contributor.author Sierra, Pilar
dc.contributor.author Sánchez Autet, Mónica
dc.contributor.author Arranz, Belén
dc.contributor.author García Blanco, Ana Cristina
dc.contributor.author Safont, Gemma
dc.contributor.author García Portilla, Maria
dc.date.accessioned 2022-06-14T18:51:06Z
dc.date.available 2022-06-14T18:51:06Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/10550/83138
dc.description.abstract Bipolar disorder (BD) has been identified as a life-course illness with different clinical manifestations from an at-risk to a late stage, supporting the assumption that it would benefit from a staging model. In a previous study, we used a clustering approach to stratify 224 patients with a diagnosis of BD into five clusters based on clinical characteristics, functioning, cognition, general health, and health-related quality of life. This study was design to test the construct validity of our previously developed k-means clustering model and to confirm its longitudinal validity over a span of 3 years. Of the 224 patients included at baseline who were used to develop our model, 129 (57.6%) reached the 3-year follow-up. All life domains except mental health-related quality of life (QoL) showed significant worsening in stages (p < 0.001), suggesting construct validity. Furthermore, as patients progressed through stages, functional decline (p < 0.001) and more complex treatment patterns (p = 0.002) were observed. As expected, at 3 years, the majority of patients remained at the same stage (49.6%), or progressed (20.9%) or regressed (23.3%) one stage. Furthermore, 85% of patients who stayed euthymic during that period remained at the same stage or regressed to previous stages, supporting its longitudinal validity. For that reason, this study provides evidence of the construct and longitudinal validity of an empirically developed, comprehensive staging model for patients with BD. Thus, it may help clinicians and researchers to better understand the disorder and, at the same time, to design more accurate and personalized treatment plans.
dc.language.iso eng
dc.relation.ispartof Translational Psychiatry, 2020, vol. 10, num. 1, p. 45
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Fuente Tomás, Lorena de la Sierra, Pilar Sánchez Autet, Mónica Arranz, Belén García Blanco, Ana Cristina Safont, Gemma García Portilla, Maria 2020 A clinical staging model for bipolar disorder : longitudinal approach. Translational Psychiatry 10 1 45
dc.subject Malalties mentals
dc.subject Salut mental
dc.title A clinical staging model for bipolar disorder : longitudinal approach.
dc.type info:eu-repo/semantics/article
dc.date.updated 2022-06-14T18:51:07Z
dc.identifier.doi https://doi.org/10.1038/s41398-020-0718-9
dc.identifier.idgrec 139980

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