Rational chemical multifunctionalization of graphene interface enhances targeted cancer therapy
NAGIOS: RODERIC FUNCIONANDO

Rational chemical multifunctionalization of graphene interface enhances targeted cancer therapy

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Rational chemical multifunctionalization of graphene interface enhances targeted cancer therapy

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Lucherelli, Matteo Andrea; Yu, Yue; Reina, Giacomo; Abellán Sáez, Gonzalo; Miyako, Eijiro; Bianco, Alberto
This document is a artículoDate2020
The synthesis of a drug delivery platform based on graphene was achieved through a step‐by‐step strategy of selective amine deprotection and functionalization. The multifunctional graphene platform, functionalized with indocyanine green, folic acid, and doxorubicin showed an enhanced anticancer activity. The remarkable targeting capacity for cancer cells in combination with the synergistic effect of drug release and photothermal properties prove the great advantage of a combined chemo‐ and phototherapy based on graphene against cancer, opening the doors to future therapeutic applications of this type of material.

    Lucherelli, Matteo Andrea Yu, Yue Reina, Giacomo Abellán Sáez, Gonzalo Miyako, Eijiro Bianco, Alberto 2020 Rational chemical multifunctionalization of graphene interface enhances targeted cancer therapy Angewandte Chemie 132 33 14138 14143
https://doi.org/10.1002/ange.201916112

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