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Copper-catalysed enantioselective Michael addition of malonic esters to β-trifluoromethyl-α,β-unsaturated imines
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Copper-catalysed enantioselective Michael addition of malonic esters to β-trifluoromethyl-α,β-unsaturated imines
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| Espinosa López, Miguel; Herrera, Jorge; Blay Llinares, Gonzalo Perfil; Cardona Prósper, María Luz; Muñoz, M. Carmen; Pedro, José Ramón | |||
| This document is a artículoDate2017 | |||
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| Copper triflate-BOX complexes catalyse the enantioselective conjugate addition of methyl malonate to β-trifluoromethyl-α,β-unsaturated imines to give the corresponding enamines bearing a trifluoromethylated stereogenic centre with good yields, and diastereo- and enantioselectivities. The usefulness of the method has been shown with the synthesis of optically active β-trifluoromethyl δ-amino esters and optically active trifluoromethylpiperidones. | |||
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Espinosa López, Miguel Herrera, Jorge Blay Llinares, Gonzalo Cardona Prósper, María Luz Muñoz, M. Carmen Pedro, José Ramón 2017 Copper-catalysed enantioselective Michael addition of malonic esters to β-trifluoromethyl-α,β-unsaturated imines Organic & Biomolecular Chemistry 15 3849 3853 |
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| https://doi.org/10.1039/C7OB00595D |
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