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Transport of Arabidopsis GPI-anchored proteins along the early secretory pathway: Role of GPI-anchor remodelling and p24 proteins

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Transport of Arabidopsis GPI-anchored proteins along the early secretory pathway: Role of GPI-anchor remodelling and p24 proteins

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	Bernat Silvestre, César Aniento Company, Fernando (dir.); Marcote Zaragoza, María Jesús (dir.) Departament de Bioquímica i Biologia Molecular
	This document is a tesisDate2019
	Las proteínas con anclaje GPI son una familia de proteínas que están ancladas a la cara exterior de la membrana plasmática mediante un ancla GPI y se ha visto que juegan un papel clave en plantas. Sin embargo, la maquinaria molecular implicada en el transporte de estas proteínas a la membrana plasmática en plantas es aún desconocida. Las proteínas p24 tienen un papel importante en el control de calidad de proteínas (posiblemente incluyendo las proteínas con anclaje GPI) transportadas entre el Retículo Endoplasmático y el aparato de Golgi. Esta tesis doctoral tiene como objetivo el estudio de la posible implicación de las proteínas p24 en la salida del Retículo Endoplasmático y en la localización en la membrana plasmática de las proteínas con anclaje GPI, y el estudio del papel del remodelado lipídico del ancla GPI para su transporte a través de la vía secretora temprana.
	GPI-anchored proteins are a family of proteins which are attached to the outer face of the plasma membrane by a GPI anchor and have been shown to play important functions in plants. However, the molecular machinery involved in transport of these proteins to the plasma membrane in plants is essentially unknown. p24 proteins play an important role in quality control during transport of proteins (possibly including GPI-anchored proteins) between ER and Golgi apparatus. This thesis aims to study the putative involvement of p24 proteins in ER export and plasma membrane localization of GPI-anchored proteins, and the role of lipid remodelling of the GPI anchor for its transport along the early secretory pathway.... [Leer más...] [-] GPI-anchored proteins are a family of proteins which are attached to the outer face of the plasma membrane by a GPI anchor and have been shown to play important functions in plants. However, the molecular machinery involved in transport of these proteins to the plasma membrane in plants is essentially unknown. p24 proteins play an important role in quality control during transport of proteins (possibly including GPI-anchored proteins) between ER and Golgi apparatus. This thesis aims to study the putative involvement of p24 proteins in ER export and plasma membrane localization of GPI-anchored proteins, and the role of lipid remodelling of the GPI anchor for its transport along the early secretory pathway.
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Tesis [7388]
24 - Ciències de la Vida [1600]

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