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Chitosan-coated mesoporous MIL-100(Fe) nanoparticles as improved bio-compatible oral nanocarriers

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Chitosan-coated mesoporous MIL-100(Fe) nanoparticles as improved bio-compatible oral nanocarriers

dc.contributor.author	Hidalgo, T.
dc.contributor.author	Giménez Marqués, Mónica
dc.contributor.author	Bellido, E.
dc.contributor.author	Avila, J.
dc.contributor.author	Asensio, M. C.
dc.contributor.author	Salles, F.
dc.contributor.author	Lozano, M. V.
dc.contributor.author	Guillevic, M.
dc.contributor.author	Simón-Vázquez, R.
dc.contributor.author	González-Fernández, A.
dc.contributor.author	Serre, C.
dc.contributor.author	Alonso, M. J.
dc.contributor.author	Horcajada, P.
dc.date.accessioned	2019-05-16T13:41:49Z
dc.date.available	2019-05-16T13:41:49Z
dc.date.issued	2017
dc.identifier.uri	http://hdl.handle.net/10550/70207
dc.description.abstract	Nanometric biocompatible Metal-Organic Frameworks (nanoMOFs) are promising candidates for drug delivery. Up to now, most studies have targeted the intravenous route, related to pain and severe complications; whereas nanoMOFs for oral administration, a commonly used non-invasive and simpler route, remains however unexplored. We propose here the biofriendly preparation of a suitable oral nanocarrier based on the benchmarked biocompatible mesoporous iron(III) trimesate nanoparticles coated with the bioadhesive polysaccharide chitosan (CS). This method does not hamper the textural/ structural properties and the sorption/release abilities of the nanoMOFs upon surface engineering. The interaction between the CS and the nanoparticles has been characterized through a combination of high resolution soft X-ray absorption and computing simulation, while the positive impact of the coating on the colloidal and chemical stability under oral simulated conditions is here demonstrated. Finally, the intestinal barrier bypass capability and biocompatibility of CS-coated nanoMOF have been assessed in vitro, leading to an increased intestinal permeability with respect to the noncoated material, maintaining an optimal biocompatibility. In conclusion, the preservation of the interesting physicochemical features of the CS-coated nanoMOF and their adapted colloidal stability and progressive biodegradation, together with their improved intestinal barrier bypass, make these nanoparticles a promising oral nanocarrier.
dc.language.iso	eng
dc.relation.ispartof	Scientific Reports, 2017, vol. 7, num. 43099, p. 1-14
dc.rights.uri	info:eu-repo/semantics/openAccess
dc.source	Hidalgo, T. Giménez Marqués, Mónica Bellido, E. Avila, J. Asensio, M. C. Salles, F. Lozano, M. V. Guillevic, M. Simón-Vázquez, R. González-Fernández, A. Serre, C. Alonso, M. J. Horcajada, P. 2017 Chitosan-coated mesoporous MIL-100(Fe) nanoparticles as improved bio-compatible oral nanocarriers Scientific Reports 7 43099 1 14
dc.subject	Nanotecnologia
dc.subject	Química organometàl·lica
dc.title	Chitosan-coated mesoporous MIL-100(Fe) nanoparticles as improved bio-compatible oral nanocarriers
dc.type	info:eu-repo/semantics/article
dc.date.updated	2019-05-16T13:41:49Z
dc.identifier.doi	https://doi.org/10.1038/srep43099
dc.identifier.idgrec	132665