Matrix metalloproteinase gene polymorphisms and oral cancer
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Matrix metalloproteinase gene polymorphisms and oral cancer

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Matrix metalloproteinase gene polymorphisms and oral cancer

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dc.contributor.author Pereira, Andresa Costa es
dc.contributor.author Dias do Carmo, Elaine es
dc.contributor.author Dias da Silva, Marco Antonio es
dc.contributor.author Blumer Rosa, Marco Antonio es
dc.date.accessioned 2014-05-21T12:45:29Z
dc.date.available 2014-05-21T12:45:29Z
dc.date.issued 2012 es
dc.identifier.uri http://hdl.handle.net/10550/35283
dc.source Pereira, Andresa Costa ; Dias do Carmo, Elaine ; Dias da Silva, Marco Antonio ; Blumer Rosa, Marco Antonio. Matrix metalloproteinase gene polymorphisms and oral cancer. En: Journal of Clinical and Experimental Dentistry, 2012, Vol. 4, No. 5: 297-301 es
dc.subject Odontología es
dc.subject Ciencias de la salud es
dc.title Matrix metalloproteinase gene polymorphisms and oral cancer es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.description.abstractenglish Since oral squamous cell carcinoma (OSCC) is the most prevalent malignant cancer in the oral cavity, several researches have been performed to study the role of important enzymes in this disease. Among them, the matrix metalloproteinases (MMPs) are highlighted, due to the fact that they are proteinases responsible to degrade many extra-cellular matrix components, making possible the invasion of neoplasic cells. Important tools in cancer prognosis have been utilized aiming to correlate high levels of MMPs and OSCC, such as immunohistochemical, zymographic and mRNA detection methods. However, these techniques are usually applied after cancer detection, characterizing a curative but not a preventive medicine. Trying to make interventions before the development of the disease and making possible the identification of people at high risk and, analysis of modifications in MMP genes has been a chance for modern medicine. Recently, polymorphisms in MMP genes have been related to different neoplasias, including OSCC. Despite investigation is beginning, MMP gene polymorphisms seems to have a promising future in oral cancer research and some of the present results have shown that there are MMP polymorphisms related to an increased risk for developing oral cancer. es

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