BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians.

Abstract
B-Cell Lymphoma-extra-large (BCL-xL) is involved in longevity and successful aging, which indicates a role for BCL-xL in cell survival pathway regulation. Beyond its well described role as an inhibitor of apoptosis by preventing cytochrome c release, BCL-xL has also been related, indirectly, to autophagy and senescence pathways. Although in these latter cases, BCL-xL has dual roles, either activating or inhibiting, depending on the cell type and the specific conditions. Taken together, all these findings suggest a precise mechanism of action for BCL-xL, able to regulate the crosstalk between apoptosis, autophagy, and senescence, thus promoting cell survival or cell death. All three pathways can be both beneficial or detrimental depending on the circumstances. Thus, targeting BCL-xL would in turn be a 'double-edge sword' and therefore, additional studies are needed to better comprehend this dual and apparently contradictory role of BCL-XL in longevity. View Full-Text Keywords: healthy aging; apoptosis; autophagy; senescence; longevity; mitochondria
Description
Bibliographic reference
Borrás, Consuelo Mas Bargues, Cristina Román Domínguez, Aurora Sanz Ros, Jorge Gimeno Mallench, Lucía Inglés de la Torre, Marta Gambini Ricapa, Juan Viña Ribes, José 2020 BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians. International Journal Of Molecular Sciences 21 2 E408