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Asymmetric Michael Addition in Synthesis of β-Substituted GABA Derivatives

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Asymmetric Michael Addition in Synthesis of β-Substituted GABA Derivatives

dc.contributor.author	Han, Jianlin
dc.contributor.author	Escorihuela Fuentes, Jorge
dc.contributor.author	Fustero Lardiés, Santos
dc.contributor.author	Landa, Aitor
dc.contributor.author	Soloshonok, Vadim A.
dc.contributor.author	Sorochinsky, Alexander
dc.date.accessioned	2023-01-18T15:04:32Z
dc.date.available	2023-01-18T15:04:32Z
dc.date.issued	2022
dc.identifier.uri	https://hdl.handle.net/10550/85019
dc.description.abstract	γ-Aminobutyric acid (GABA) represents one of the most prolific structural units widely used in the design of modern pharmaceuticals. For example, β-substituted GABA derivatives are found in numerous neurological drugs, such as baclofen, phenibut, tolibut, pregabalin, phenylpiracetam, brivaracetam, and rolipram, to mention just a few. In this review, we critically discuss the literature data reported on the preparation of substituted GABA derivatives using the Michael addition reaction as a key synthetic transformation. Special attention is paid to asymmetric methods featuring synthetically useful stereochemical outcomes and operational simplicity.
dc.language.iso	eng
dc.relation.ispartof	Molecules, 2022, vol. 27, num. 12, p. 3797
dc.source	Han, Jianlin Escorihuela Fuentes, Jorge Fustero Lardiés, Santos Landa, Aitor Soloshonok, Vadim A. Sorochinsky, Alexander 2022 Asymmetric Michael Addition in Synthesis of β-Substituted GABA Derivatives Molecules 27 12 3797
dc.subject	Química farmacèutica
dc.subject	Medicaments
dc.subject	Reaccions químiques
dc.title	Asymmetric Michael Addition in Synthesis of β-Substituted GABA Derivatives
dc.type	journal article	es_ES
dc.date.updated	2023-01-18T15:04:32Z
dc.identifier.doi	https://doi.org/10.3390/molecules27123797
dc.identifier.idgrec	156450
dc.rights.accessRights	open access	es_ES