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A Cu-BOX catalysed enantioselective Mukaiyama-aldol reaction with difluorinated silyl enol ethers and acylpyridine N-oxides

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A Cu-BOX catalysed enantioselective Mukaiyama-aldol reaction with difluorinated silyl enol ethers and acylpyridine N-oxides

dc.contributor.author	Sanz Marco, Amparo
dc.contributor.author	Esperilla, Daniel
dc.contributor.author	Montesinos Magraner, Marc
dc.contributor.author	Vila Descals, Carlos
dc.contributor.author	Muñoz, M. Carmen
dc.contributor.author	Pedro, José Ramón
dc.contributor.author	Blay Llinares, Gonzalo
dc.date.accessioned	2023-01-10T13:50:11Z
dc.date.available	2023-01-10T13:50:11Z
dc.date.issued	2023
dc.identifier.uri	https://hdl.handle.net/10550/84931
dc.description.abstract	A Cu(II)/BOX complex catalyses the enantioselective addition of difluorinated silyl enol ethers to acylpyridine N-oxides. The reaction provides difluorinated chiral tertiary alcohols of great interest in medicinal chemistry. These compounds are obtained in moderate to excellent yields and with high enantioselectivities. The stereochemical outcome of the reaction has been explained by DFT calculations.
dc.language.iso	eng
dc.relation.ispartof	Organic & Biomolecular Chemistry, 2023, vol. 21, num. 2, p. 345-350
dc.source	Sanz Marco, Amparo Esperilla, Daniel Montesinos Magraner, Marc Vila Descals, Carlos Muñoz, M. Carmen Pedro, José Ramón Blay Llinares, Gonzalo 2023 A Cu-BOX catalysed enantioselective Mukaiyama-aldol reaction with difluorinated silyl enol ethers and acylpyridine N-oxides Organic & Biomolecular Chemistry 21 2 345 350
dc.subject	Química orgànica
dc.subject	Catàlisi
dc.title	A Cu-BOX catalysed enantioselective Mukaiyama-aldol reaction with difluorinated silyl enol ethers and acylpyridine N-oxides
dc.type	journal article	es_ES
dc.date.updated	2023-01-10T13:50:11Z
dc.identifier.doi	https://doi.org/10.1039/D2OB01763F
dc.identifier.idgrec	156282
dc.rights.accessRights	open access	es_ES