A Cu-BOX catalysed enantioselective Mukaiyama-aldol reaction with difluorinated silyl enol ethers and acylpyridine N-oxides
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A Cu-BOX catalysed enantioselective Mukaiyama-aldol reaction with difluorinated silyl enol ethers and acylpyridine N-oxides

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A Cu-BOX catalysed enantioselective Mukaiyama-aldol reaction with difluorinated silyl enol ethers and acylpyridine N-oxides

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Sanz Marco, Amparo; Esperilla, Daniel; Montesinos Magraner, Marc; Vila Descals, Carlos; Muñoz, M. Carmen; Pedro, José Ramón; Blay Llinares, Gonzalo Perfil
This document is a artículoDate2023
A Cu(II)/BOX complex catalyses the enantioselective addition of difluorinated silyl enol ethers to acylpyridine N-oxides. The reaction provides difluorinated chiral tertiary alcohols of great interest in medicinal chemistry. These compounds are obtained in moderate to excellent yields and with high enantioselectivities. The stereochemical outcome of the reaction has been explained by DFT calculations.

    Sanz Marco, Amparo Esperilla, Daniel Montesinos Magraner, Marc Vila Descals, Carlos Muñoz, M. Carmen Pedro, José Ramón Blay Llinares, Gonzalo 2023 A Cu-BOX catalysed enantioselective Mukaiyama-aldol reaction with difluorinated silyl enol ethers and acylpyridine N-oxides Organic & Biomolecular Chemistry 21 2 345 350
https://doi.org/10.1039/D2OB01763F

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