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Crosstalk between Mu-Opioid receptors and neuroinflammation: Consequences for drug addiction and pain

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Crosstalk between Mu-Opioid receptors and neuroinflammation: Consequences for drug addiction and pain

dc.contributor.author	Cuitavi, Javier
dc.contributor.author	Torres-Perez, Jose V.
dc.contributor.author	Lorente, Jesús David
dc.contributor.author	Campos Jurado, Yolanda María
dc.contributor.author	Andrés-Herrera, Paula
dc.contributor.author	Polache Vengut, Ana
dc.contributor.author	Agustín-Pavón, Carmen
dc.contributor.author	Hipólito Cubedo, Lucía
dc.date.accessioned	2023-01-09T14:31:52Z
dc.date.available	2023-01-09T14:31:52Z
dc.date.issued	2022
dc.identifier.uri	https://hdl.handle.net/10550/84917
dc.description.abstract	Mu-Opioid Receptors (MORs) are well-known for participating in analgesia, sedation, drug addiction, and other physiological functions. Although MORs have been related to neuroinflammation their biological mechanism remains unclear. It is suggested that MORs work alongside Toll-Like Receptors to enhance the release of pro-inflammatory mediators and cytokines during pathological conditions. Some cytokines, including TNF-α, IL-1β and IL-6, have been postulated to regulate MORs levels by both avoiding MOR recycling and enhancing its production. In addition, Neurokinin-1 Receptor, also affected during neuroinflammation, could be regulating MOR trafficking. Therefore, inflammation in the central nervous system seems to be associated with altered/increased MORs expression, which might regulate harmful processes, such as drug addiction and pain. Here, we provide a critical evaluation on MORs' role during neuroinflammation and its implication for these conditions. Understanding MORs' functioning, their regulation and implications on drug addiction and pain may help elucidate their potential therapeutic use against these pathological conditions and associated disorders.
dc.language.iso	eng
dc.relation.ispartof	Neuroscience and Biobehavioral Reviews, 2022, vol. 145, num. 105011
dc.source	Cuitavi, Javier Torres-Perez, Jose V. Lorente, Jesús David Campos Jurado, Yolanda María Andrés-Herrera, Paula Polache Vengut, Ana Agustín-Pavón, Carmen Hipólito Cubedo, Lucía 2022 Crosstalk between Mu-Opioid receptors and neuroinflammation: Consequences for drug addiction and pain Neuroscience and Biobehavioral Reviews 145 105011
dc.subject	Neurociències
dc.subject	Drogoaddicció
dc.title	Crosstalk between Mu-Opioid receptors and neuroinflammation: Consequences for drug addiction and pain
dc.type	journal article	es_ES
dc.date.updated	2023-01-09T14:31:53Z
dc.identifier.doi	https://doi.org/10.1016/j.neubiorev.2022.105011
dc.identifier.idgrec	156203
dc.rights.accessRights	open access	es_ES