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Cyclin-Dependent Kinase Inhibitor p21 Controls Adult Neural Stem Cell Expansion by Regulating Sox2 Gene Expression

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Cyclin-Dependent Kinase Inhibitor p21 Controls Adult Neural Stem Cell Expansion by Regulating Sox2 Gene Expression

dc.contributor.author	Marqués-Torrejón, M. Ángeles
dc.contributor.author	Porlan Alonso, Eva
dc.contributor.author	Banito, Ana
dc.contributor.author	Gómez-Ibarlucea, Esther
dc.contributor.author	López-Contreras, Andrés J.
dc.contributor.author	Fernández-Capetillo, Óscar
dc.contributor.author	Vidal, Anxo
dc.contributor.author	Gil, Jesús
dc.contributor.author	Torres Ibáñez, José Manuel
dc.contributor.author	Fariñas Gómez, Isabel
dc.date.accessioned	2022-11-02T18:36:10Z
dc.date.available	2022-11-02T18:36:10Z
dc.date.issued	2013
dc.identifier.uri	https://hdl.handle.net/10550/84372
dc.description.abstract	In the adult brain, continual neurogenesis of olfactory neurons is sustained by the existence of neural stem cells (NSCs) in the subependymal niche. Elimination of the cyclin-dependent kinase inhibitor 1A (p21) leads to premature exhaustion of the subependymal NSC pool, suggesting a relationship between cell cycle control and long-term self-renewal, but the molecular mechanisms underlying NSC maintenance by p21 remain unexplored. Here we identify a function of p21 in the direct regulation of the expression of pluripotency factor Sox2, a key regulator of the specification and maintenance of neural progenitors. We observe that p21 directly binds a Sox2 enhancer and negatively regulates Sox2 expression in NSCs. Augmented levels of Sox2 in p21 null cells induce replicative stress and a DNA damage response that leads to cell growth arrest mediated by increased levels of p19Arf and p53. Our results show a regulation of NSC expansion driven by a p21/Sox2/p53 axis.
dc.language.iso	eng
dc.relation.ispartof	Cell Stem Cell, 2013, vol. 12, num. 1, p. 88-100
dc.source	Marqués-Torrejón, M. Ángeles Porlan Alonso, Eva Banito, Ana Gómez-Ibarlucea, Esther López-Contreras, Andrés J. Fernández-Capetillo, Óscar Vidal, Anxo Gil, Jesús Torres Ibáñez, José Manuel Fariñas Gómez, Isabel 2013 Cyclin-Dependent Kinase Inhibitor p21 Controls Adult Neural Stem Cell Expansion by Regulating Sox2 Gene Expression Cell Stem Cell 12 1 88 100
dc.subject	Cèl·lules mare neurals
dc.subject	Expressió genètica
dc.title	Cyclin-Dependent Kinase Inhibitor p21 Controls Adult Neural Stem Cell Expansion by Regulating Sox2 Gene Expression
dc.type	journal article	es_ES
dc.date.updated	2022-11-02T18:36:11Z
dc.identifier.doi	https://doi.org/10.1016/j.stem.2012.12.001
dc.identifier.idgrec	080774
dc.rights.accessRights	open access	es_ES