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Understanding the microbial biogeography of ancient human dentitions to guide study design and interpretation

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Understanding the microbial biogeography of ancient human dentitions to guide study design and interpretation

dc.contributor.author	Fägernas, Zandra
dc.contributor.author	Salazar García, Domingo Carlos
dc.contributor.author	Haber Uriarte, María
dc.contributor.author	Avilés Fernámdez, Azucena
dc.contributor.author	Henry, Amanda G.
dc.contributor.author	Lomba Maurandi, Joaquín
dc.contributor.author	Ozga, Andrew T.
dc.contributor.author	Velsko, Irina M.
dc.contributor.author	Warinner, Christina
dc.date.accessioned	2022-06-27T10:47:29Z
dc.date.available	2022-06-27T10:47:29Z
dc.date.issued	2022
dc.identifier.uri	https://hdl.handle.net/10550/83273
dc.description.abstract	The oral cavity is a heterogeneous environment, varying in factors such as pH, oxygen levels, and salivary flow. These factors affect the microbial community composition and distribution of species in dental plaque, but it is not known how well these patterns are reflected in archaeological dental calculus. Inmost archaeological studies, a single sample of dental calculus is studied per individual and is assumed to represent the entire oral cavity. However, it is not known if this sampling strategy introduces biases into studies of the ancient oral microbiome. Here, we present the results of a shotgun metagenomic study of a dense sampling of dental calculus from four Chalcolithic individuals from the southeast Iberian peninsula (ca. 4500-5000 BP). Interindividual differences in microbial composition are found to be much larger than intraindividual differences, indicating that a single sample can indeed represent an individual in most cases. However, there are minor spatial patterns in species distribution within the oral cavity that should be taken into account when designing a study or interpreting results. Finally, we show that plant DNA identified in the samples is likely of postmortem origin, demonstrating the importance of including environmental controls or additional lines of biomolecular evidence in dietary interpretations.
dc.language.iso	eng
dc.relation.ispartof	FEM Microbes, 2022, vol. 3, p. 1-13
dc.source	Fägernas, Zandra Salazar García, Domingo Carlos Haber Uriarte, María Avilés Fernámdez, Azucena Henry, Amanda G. Lomba Maurandi, Joaquín Ozga, Andrew T. Velsko, Irina M. Warinner, Christina 2022 Understanding the microbial biogeography of ancient human dentitions to guide study design and interpretation FEM Microbes 3 1 13
dc.subject	Restes humanes (Arqueologia)
dc.title	Understanding the microbial biogeography of ancient human dentitions to guide study design and interpretation
dc.type	journal article	es_ES
dc.date.updated	2022-06-27T10:47:30Z
dc.identifier.doi	https://doi.org/10.1093/femsmc/xtac006
dc.identifier.idgrec	153974
dc.rights.accessRights	open access	es_ES