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Resilience to social defeat stress in adolescent male mice

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Resilience to social defeat stress in adolescent male mice

dc.contributor.author	Reguilón, Marina D.
dc.contributor.author	Ballestín Hinojosa, Raúl
dc.contributor.author	Miñarro López, José
dc.contributor.author	Rodríguez Arias, Marta
dc.date.accessioned	2022-06-14T15:09:33Z
dc.date.available	2022-06-14T15:09:33Z
dc.date.issued	2022
dc.identifier.uri	https://hdl.handle.net/10550/83137
dc.description.abstract	Adverse social experiences during adolescence are associated with the appearance of mental illness in adulthood. Social defeat (SD) is an ethologically valid murine model to study the consequences of social stress. In adolescent mice, SD induces depressive-like behaviors, increased anxiety and potentiates the reinforcing effects of cocaine and alcohol. However, not all mice exposed to SD will be susceptible to these effects. Adult mice resilient to the effects of SD show a consistent phenotype being resilient to depressive-like behaviors and to the increase in cocaine and alcohol consumption. The aim of the present study was to characterize the resilient phenotype to depressive-like behaviors and increase cocaine and ethanol rewarding effects of mice socially defeated during adolescence. To that end, adolescent mice were exposed to repeated SD, and 24 h after the last encounter, they underwent a social interaction test (SIT) in order to evaluate depressive-like behaviors. Cocaine-induced reward conditioning and ethanol intake was evaluated in two different sets of mice 3 weeks after the last SD using cocaine-induced conditioned place preference (CPP) and oral ethanol self-administration (SA). The neuroinflammation response was measured at the end of the experimental procedure by measuring striatal and cortical levels of IL-6 and CX3CL1. The results confirmed that a comparable percentage of adolescent mice develop resilience to depressive-like behaviors to that observed in adult mice. However, increased anxiety was more severe in resilient mice. Likewise, an increased preference for an ineffective dose of cocaine and an increased ethanol consumption was observed in resilient mice compared to controls. The increase in IL-6 and CX3CL1 was mainly observed in the striatum of susceptible mice compared to that of control mice. Our results confirm that, contrary to prior assumptions in adults, responses to SD stress are more complex and singular in adolescents, and caution should be taken for the correct interpretation and translation of those phenotypes.
dc.language.iso	eng
dc.relation.ispartof	Progress in Neuro-Psychopharmacology & Biological Psychiatry, 2022, vol. 119
dc.source	Reguilón, Marina D. Ballestín Hinojosa, Raúl Miñarro López, José Rodríguez Arias, Marta 2022 Resilience to social defeat stress in adolescent male mice Progress in Neuro-Psychopharmacology & Biological Psychiatry 119
dc.subject	Psicobiologia
dc.subject	Adolescents Psicologia
dc.title	Resilience to social defeat stress in adolescent male mice
dc.type	journal article	es_ES
dc.date.updated	2022-06-14T15:09:33Z
dc.identifier.doi	https://doi.org/10.1016/j.pnpbp.2022.110591
dc.identifier.idgrec	154170
dc.rights.accessRights	open access	es_ES