ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex
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ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex

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ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex

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dc.contributor.author Medeiros de Araújo, Jéssica Alves
dc.contributor.author Barão, Soraia
dc.contributor.author Mateos-White, Isabel
dc.contributor.author Espinosa, Ana
dc.contributor.author Costa, Marcos R.
dc.contributor.author Gil-Sanz, Cristina
dc.contributor.author Müller, Ulrich
dc.date.accessioned 2022-05-13T17:13:01Z
dc.date.available 2022-05-13T17:13:01Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/10550/82771
dc.description.abstract Neocortical progenitor cells generate subtypes of excitatory projection neurons in sequential order followed by the generation of astrocytes. The transcription factor zinc finger and BTB domain-containing protein 20 (ZBTB20) has been implicated in regulation of cell specification during neocortical development. Here, we show that ZBTB20 instructs the generation of a subset of callosal projections neurons in cortical layers II/III in mouse. Conditional deletion of Zbtb20 in cortical progenitors, and to a lesser degree in differentiating neurons, leads to an increase in the number of layer IV neurons at the expense of layer II/III neurons. Astrogliogenesis is also affected in the mutants with an increase in the number of a specific subset of astrocytes expressing GFAP. Astrogliogenesis is more severely disrupted by a ZBTB20 protein containing dominant mutations linked to Primrose syndrome, suggesting that ZBTB20 acts in concert with other ZBTB proteins that were also affected by the dominant-negative protein to instruct astrogliogenesis. Overall, our data suggest that ZBTB20 acts both in progenitors and in postmitotic cells to regulate cell fate specification in the mammalian neocortex.
dc.language.iso eng
dc.relation.ispartof Development, 2021, vol. 148, num. 16, p. dev196642
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Medeiros de Araújo, Jéssica Alves Barão, Soraia Mateos-White, Isabel Espinosa, Ana Costa, Marcos R. Gil-Sanz, Cristina Mu&#776ller, Ulrich 2021 ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex Development 148 16 dev196642
dc.subject Neurones
dc.subject Cèl·lules
dc.title ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex
dc.type info:eu-repo/semantics/article
dc.date.updated 2022-05-13T17:13:03Z
dc.identifier.doi https://doi.org/10.1242/dev.196642
dc.identifier.idgrec 153045
dc.embargo.terms 1 year
dc.embargo.liftdate 2022-08-19

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