Non-invasive Spatial Mapping of Frequencies in Atrial Fibrillation: Correlation With Contact Mapping
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Non-invasive Spatial Mapping of Frequencies in Atrial Fibrillation: Correlation With Contact Mapping

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Non-invasive Spatial Mapping of Frequencies in Atrial Fibrillation: Correlation With Contact Mapping

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dc.contributor.author Rodrigo Bort, Miguel
dc.contributor.author Waddell, Kian
dc.contributor.author Magee, Sarah
dc.contributor.author Rogers, A. J.
dc.contributor.author Alhusseini, Mahmood I.
dc.contributor.author Hernández-Romero, Ismael
dc.contributor.author Costoya-Sánchez, Alejandro
dc.contributor.author Liberos, Alejandro
dc.contributor.author Narayan, Sanjiv M.
dc.date.accessioned 2022-05-13T14:31:33Z
dc.date.available 2022-05-13T14:31:33Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/10550/82769
dc.description.abstract Introduction: Regional differences in activation rates may contribute to the electrical substrates that maintain atrial fibrillation (AF), and estimating them non-invasively may help guide ablation or select anti-arrhythmic medications. We tested whether non-invasive assessment of regional AF rate accurately represents intracardiac recordings. Methods: In 47 patients with AF (27 persistent, age 63 ± 13 years) we performed 57-lead non-invasive Electrocardiographic Imaging (ECGI) in AF, simultaneously with 64-pole intracardiac signals of both atria. ECGI was reconstructed by Tikhonov regularization. We constructed personalized 3D AF rate distribution maps by Dominant Frequency (DF) analysis from intracardiac and non-invasive recordings. Results: Raw intracardiac and non-invasive DF differed substantially, by 0.54 Hz [0.13 - 1.37] across bi-atrial regions (R2 = 0.11). Filtering by high spectral organization reduced this difference to 0.10 Hz (cycle length difference of 1 - 11 ms) [0.03 - 0.42] for patient-level comparisons (R2 = 0.62), and 0.19 Hz [0.03 - 0.59] and 0.20 Hz [0.04 - 0.61] for median and highest DF, respectively. Non-invasive and highest DF predicted acute ablation success (p = 0.04). Conclusion: Non-invasive estimation of atrial activation rates is feasible and, when filtered by high spectral organization, provide a moderate estimate of intracardiac recording rates in AF. Non-invasive technology could be an effective tool to identify patients who may respond to AF ablation for personalized therapy.
dc.language.iso eng
dc.relation.ispartof Frontiers In Physiology, 2021, vol. 11, num. 611266
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Rodrigo Bort, Miguel Waddell, Kian Magee, Sarah Rogers, A. J. Alhusseini, Mahmood I. Hernández-Romero, Ismael Costoya-Sánchez, Alejandro Liberos, Alejandro Narayan, Sanjiv M. 2021 Non-invasive Spatial Mapping of Frequencies in Atrial Fibrillation: Correlation With Contact Mapping Frontiers In Physiology 11 611266
dc.subject Imatges tridimensionals en medicina
dc.subject Enginyeria biomèdica
dc.title Non-invasive Spatial Mapping of Frequencies in Atrial Fibrillation: Correlation With Contact Mapping
dc.type info:eu-repo/semantics/article
dc.date.updated 2022-05-13T14:31:33Z
dc.identifier.doi https://doi.org/10.3389/fphys.2020.611266
dc.identifier.idgrec 152895

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