Oxytocin prevents the increase of cocaine-related responses produced by social defeat
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Oxytocin prevents the increase of cocaine-related responses produced by social defeat

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Oxytocin prevents the increase of cocaine-related responses produced by social defeat

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dc.contributor.author Ferrer-Pérez, Carmen
dc.contributor.author Castro-Zavala, Adriana
dc.contributor.author Luján, Miguel Ángel
dc.contributor.author Filarowska, Joanna
dc.contributor.author Ballestín, Raúl
dc.contributor.author Miñarro López, José
dc.contributor.author Valverde, Olga
dc.contributor.author Arenas, M.Carmen
dc.contributor.author Manzanedo, Carmen
dc.contributor.author Rodríguez-Árias, Marta
dc.date.accessioned 2022-04-07T11:50:58Z
dc.date.available 2022-04-08T04:45:05Z
dc.date.issued 2018 es_ES
dc.identifier.uri https://hdl.handle.net/10550/82220
dc.description.abstract The neuropeptide oxytocin (OXT) plays a critical role in the regulation of social and emotional behaviors. OXT plays a role in the stress response and in drug reward, but to date no studies have evaluated its implication in the long-lasting increase of the motivational effects of cocaine induced by repeated social defeat (SD). During the social defeat procedure, 1 mg/kg of OXT was administered 30 minutes before each episode of SD. Three weeks after the last defeat, the effects of cocaine on conditioned place preference (CPP), locomotor sensitization and the self-administration (SA) paradigm were evaluated. Our results confirm that raising the levels of OXT during social defeat stress can block the long-lasting effects of this type of stress. OXT counteracts the anxiety induced by SD. Moreover, OXT prevents SD-induced increases in the motivational effects of cocaine. Administration of OXT before each social defeat blocked the SD-induced increment in the conditioned rewarding effects of cocaine in the CPP, favors the extinction of cocaine-associated memories in both the CPP and SA, and decreases reinstatement of cocaine-seeking behavior in the SA. In conclusion, the long-lasting effects of SD are counteracted by administering OXT prior to stress. es_ES
dc.description.sponsorship Prometeo/2018/132 es_ES
dc.language.iso es es_ES
dc.source Póster 2018-10-05 Reunión RTA Barcelona es_ES
dc.title Oxytocin prevents the increase of cocaine-related responses produced by social defeat es_ES
dc.type info:eu-repo/semantics/conferenceObject es_ES
dc.subject.unesco UNESCO::PSICOLOGÍA es_ES
dc.accrualMethod - es_ES
dc.embargo.terms 0 days es_ES

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