High efficiency in vitro wound healing of dictyophora indusiata extracts via anti-inflammatory and collagen stimulating (MMP-2 inhibition) mechanisms
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High efficiency in vitro wound healing of dictyophora indusiata extracts via anti-inflammatory and collagen stimulating (MMP-2 inhibition) mechanisms

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High efficiency in vitro wound healing of dictyophora indusiata extracts via anti-inflammatory and collagen stimulating (MMP-2 inhibition) mechanisms

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dc.contributor.author Nazir, Yasir
dc.contributor.author Linsaenkart, Pichchapa
dc.contributor.author Khantham, Chiranan
dc.contributor.author Chaitep, Tanakarn
dc.contributor.author Jantrawut, Pensark
dc.contributor.author Chittasupho, Chuda
dc.contributor.author Rachtanapun, Pornchai
dc.contributor.author Jantanasakulwong, Kittisak
dc.contributor.author Phimolsiripol, Yuthana
dc.contributor.author Sommano, Sarana Rose
dc.contributor.author Tocharus, Jinaporn
dc.contributor.author Mingmalairak, Salin
dc.contributor.author Wongsa, Anchali
dc.contributor.author Arjin, Chaiwat
dc.contributor.author Sringarm, Korawan
dc.contributor.author Berrada Ramdani, Houda
dc.contributor.author Barba Orellana, Francisco José
dc.contributor.author Ruksiriwanich, Warintorn
dc.date.accessioned 2022-04-04T09:45:59Z
dc.date.available 2022-04-04T09:45:59Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/10550/82142
dc.description.abstract Dictyophora indusiata or Phallus indusiatus is widely used as not only traditional medicine, functional foods, but also, skin care agents. Biological activities of the fruiting body from D. indusiata were widely reported, while the studies on the application of immature bamboo mushroom extracts were limited especially in the wound healing effect. Wound healing process composed of 4 stages including hemostasis, inflammation, proliferation, and remodelling. This study divided the egg stage of bamboo mushroom into 3 parts: peel and green mixture (PGW), core (CW), and whole mushroom (WW). Then, aqueous extracts were investigated for their nucleotide sequencing, biological compound contents, and wound healing effect. The anti-inflammatory determination via the levels of cytokine releasing from macrophages, and the collagen stimulation activity on fibroblasts by matrix metalloproteinase-2 (MMP-2) inhibitory activity were determined to serve for the wound healing process promotion in the stage 2-4 (wound inflammation, proliferation, and remodelling of the skin). All D. indusiata extracts showed good antioxidant potential, significantly anti-inflammatory activity in the decreasing of the nitric oxide (NO), interleukin-1 (IL-1), interleukin-1 (IL-6), and tumour necrosis factor-α (TNF-α) secretion from macrophage cells (p < 0.05), and the effective collagen stimulation via MMP-2 inhibition. In particular, CW extract containing high content of catechin (68.761 ± 0.010 mg/g extract) which could significantly suppress NO secretion (0.06 ± 0.02 µmol/L) better than the standard anti-inflammatory drug diclofenac (0.12 ± 0.02 µmol/L) and their MMP-2 inhibition (41.33 ± 9.44%) was comparable to L-ascorbic acid (50.65 ± 2.53%). These findings support that CW of D. indusiata could be an essential natural active ingredient for skin wound healing pharmaceutical products.
dc.language.iso eng
dc.relation.ispartof Journal Of Fungi, 2021, vol. 7, num. 12, p. 1-18
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Nazir, Yasir Linsaenkart, Pichchapa Khantham, Chiranan Chaitep, Tanakarn Jantrawut, Pensark Chittasupho, Chuda Rachtanapun, Pornchai Jantanasakulwong, Kittisak Phimolsiripol, Yuthana Sommano, Sarana Rose Tocharus, Jinaporn Mingmalairak, Salin Wongsa, Anchali Arjin, Chaiwat Sringarm, Korawan Berrada, Houda Barba Orellana, Francisco José Ruksiriwanich, Warintorn 2021 High efficiency in vitro wound healing of dictyophora indusiata extracts via anti-inflammatory and collagen stimulating (MMP-2 inhibition) mechanisms Journal Of Fungi 7 12 1 18
dc.subject Química farmacèutica
dc.title High efficiency in vitro wound healing of dictyophora indusiata extracts via anti-inflammatory and collagen stimulating (MMP-2 inhibition) mechanisms
dc.type info:eu-repo/semantics/article
dc.date.updated 2022-04-04T09:45:59Z
dc.identifier.doi https://doi.org/10.3390/jof7121100
dc.identifier.idgrec 151114

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