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Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms

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	del Olmo García, María Isabel; Prado-Wohlwend, Stefan; Andres, Alexia; Soriano del Castillo, José Miguel; Bello, Pilar; Merino Torres, Juan Francisco
	This document is a artículoDate2021
	Neuroendocrine neoplasms (NENs) are heterogeneous neoplasms which arise from neuroendocrine cells that are distributed widely throughout the body. Although heterogenous, many of them share their ability to overexpress somatostatin receptors (SSTR) on their cell surface. Due to this, SSTR and somatostatin have been a large subject of interest in the discovery of potential biomarkers and treatment options for the disease. The aim of this review is to describe the molecular characteristics of somatostatin and somatostatin receptors and its application in diagnosis and therapy on patients with NENs as well as the use in the near future of somatostatin antagonists.
	del Olmo García, María Isabel Prado-Wohlwend, Stefan Andres, Alexia Soriano del Castillo, José Miguel Bello, Pilar Merino Torres, Juan Francisco 2021 Somatostatin and Somatostatin Receptors: From Signaling to Clinical Applications in Neuroendocrine Neoplasms Biomedicines 9 12 1810
	https://doi.org/10.3390/biomedicines9121810