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Effectiveness of Leukocyte and Platelet-Rich Fibrin Versus Nitrofurazone on Nail Post-Surgery Bleeding and Wound Cicatrization Period Reductions : A Randomized Single Blinded Clinical Trial

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Effectiveness of Leukocyte and Platelet-Rich Fibrin Versus Nitrofurazone on Nail Post-Surgery Bleeding and Wound Cicatrization Period Reductions : A Randomized Single Blinded Clinical Trial

dc.contributor.author	Garrido Castells, Xavier
dc.contributor.author	Becerro de Bengoa Vallejo, Ricardo
dc.contributor.author	Calvo Lobo, César
dc.contributor.author	Losa Iglesias, Marta Elena
dc.contributor.author	Palomo López, Patricia
dc.contributor.author	Navarro Flores, Emmanuel
dc.contributor.author	López López, Daniel
dc.date.accessioned	2022-02-15T17:10:39Z
dc.date.available	2022-02-15T17:10:39Z
dc.date.issued	2019
dc.identifier.uri	https://hdl.handle.net/10550/81646
dc.description.abstract	Leukocyte and platelet-rich fibrin (L-PRF) may be considered a co-adjuvant intervention that may play a key role in blood coagulation and tissue repair after nail surgeries. The aim of this study was to determine the e ectiveness of L-PRF versus nitrofurazone on the post-surgical bleeding and wound cicatrization period in patients with bilateral onychocryptosis during surgeries of chemical matrixectomies with 88% phenol solution. Methods: A randomized single-blind clinical trial was registered with the European Clinical Trials Database (EudraCT) with identification number 2016-002048-18. Twenty healthy participants with bilateral onychocryptosis (n = 40) were recruited and bilaterally received both protocols for both halluces. Patients with a mean age mean of 45.55 12.19 years attended a specialized foot and ankle surgery clinic. Both halluces of each patient were randomized and allocated to receive L-PRF (experimental group; n = 20 halluces) or nitrofurazone (control group; n = 20 halluces) interventions in conjunction with surgery of chemical matrixectomies with 88% phenol solution for bilateral ingrown of toenail border (medial and lateral). Patients were blinded to their intervention in each hallux. The primary outcome measurement was post-surgical bleeding. The secondary outcome measurements were post-surgical pain intensity, inflammation, infection, analgesic intake, and wound cicatrization period. Results: Statistically significant di erences (p < 0.001) were found between both groups showing a reduction for wound cicatrization period and post-surgical bleeding for the L-PRF intervention with respect to nitrofurazone treatment. The rest of the outcome measurements did not show any statistically significant di erences (p > 0.05). Conclusions: L-PRF rather than nitrofurazone in conjunction with chemical matrixectomies performed with 88% phenol solution reduced the wound cicatrization period and bleeding after nail surgery. Thus, L-PRF may be considered a first-line co-adjuvant intervention for patients who su er from nail problems, such as onychocryptosis, that require surgical procedures
dc.language.iso	eng
dc.relation.ispartof	Journal Of Clinical Medicine, 2019
dc.rights.uri	info:eu-repo/semantics/openAccess
dc.source	Garrido Castells, Xavier Becerro de Bengoa Vallejo, Ricardo Calvo Lobo, César Losa Iglesias, Marta Elena Palomo López, Patricia Navarro Flores, Emmanuel López López, Daniel 2019 Effectiveness of Leukocyte and Platelet-Rich Fibrin Versus Nitrofurazone on Nail Post-Surgery Bleeding and Wound Cicatrization Period Reductions : A Randomized Single Blinded Clinical Trial Journal Of Clinical Medicine
dc.subject	Postoperatori
dc.subject	Ferides i lesions Tractament
dc.subject	Extremitats
dc.title	Effectiveness of Leukocyte and Platelet-Rich Fibrin Versus Nitrofurazone on Nail Post-Surgery Bleeding and Wound Cicatrization Period Reductions : A Randomized Single Blinded Clinical Trial
dc.type	info:eu-repo/semantics/article
dc.date.updated	2022-02-15T17:10:40Z
dc.identifier.doi	https://doi.org/10.3390/jcm8101552
dc.identifier.idgrec	137911