Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2
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Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2

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Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2

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dc.contributor.author Ferrer, María D.
dc.contributor.author Sánchez Barrueco, Álvaro
dc.contributor.author Martínez Beneyto, Yolanda
dc.contributor.author Mateos Moreno, María Victoria
dc.contributor.author Ausina Márquez, Verónica
dc.contributor.author García Vázquez, Elisa
dc.contributor.author Puche Torres, Miguel
dc.contributor.author Forner Giner, María José
dc.contributor.author Campos González, Alfonso
dc.contributor.author Santillán Coello, Jessica
dc.contributor.author Alcalá Rueda, Ignacio
dc.contributor.author Villacampa Aubá, José M.
dc.contributor.author Cenjor Español, Carlos
dc.contributor.author López Velasco, Ana
dc.contributor.author Santolaya Abad, Diego
dc.contributor.author García Esteban, Sandra
dc.contributor.author Artacho, Alejandro
dc.contributor.author López Labrador, Francesc Xavier
dc.contributor.author Mira, Alex
dc.date.accessioned 2022-01-11T15:20:17Z
dc.date.available 2022-01-11T15:20:17Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/10550/81301
dc.description.abstract Most public health measures to contain the COVID-19 pandemic are based on preventing the pathogen spread, and the use of oral antiseptics has been proposed as a strategy to reduce transmission risk. The aim of this manuscript is to test the efficacy of mouthwashes to reduce salivary viral load in vivo. This is a multi-centre, blinded, parallel-group, placebo-controlled randomised clinical trial that tests the effect of four mouthwashes (cetylpyridinium chloride, chlorhexidine, povidone-iodine and hydrogen peroxide) in SARS-CoV-2 salivary load measured by qPCR at baseline and 30, 60 and 120 min after the mouthrinse. A fifth group of patients used distilled water mouthrinse as a control. Eighty-four participants were recruited and divided into 12-15 per group. There were no statistically significant changes in salivary viral load after the use of the different mouthwashes. Although oral antiseptics have shown virucidal effects in vitro, our data show that salivary viral load in COVID-19 patients was not affected by the tested treatments. This could reflect that those mouthwashes are not effective in vivo, or that viral particles are not infective but viral RNA is still detected by PCR. Viral infectivity studies after the use of mouthwashes are therefore required.
dc.language.iso eng
dc.relation.ispartof Scientific Reports, 2021
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Ferrer, María D. Sánchez Barrueco, Álvaro Martínez Beneyto, Yolanda Mateos Moreno, María Victoria Ausina Márquez, Verónica García Vázquez, Elisa Puche Torres, Miguel Forner Giner, María José Campos González, Alfonso Santillán Coello, Jessica Alcalá Rueda, Ignacio Villacampa Aubá, José M. Cenjor Español, Carlos López Velasco, Ana Santolaya Abad, Diego García Esteban, Sandra Artacho, Alejandro López Labrador, Francesc Xavier Mira, Alex 2021 Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2 Scientific Reports
dc.subject Virus
dc.subject Malalties transmissibles Prevenció
dc.title Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2
dc.type info:eu-repo/semantics/article
dc.date.updated 2022-01-11T15:20:18Z
dc.identifier.doi https://doi.org/10.1038/s41598-021-03461-y
dc.identifier.idgrec 149558

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