Enantioselective addition of sodium bisulfite to nitroalkenes. A convenient approach to chiral sulfonic acids

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Enantioselective addition of sodium bisulfite to nitroalkenes. A convenient approach to chiral sulfonic acids

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	Sheikhi, Ehsan; Rezaei, Narjes; Castilla, Alvaro; Sanz Marco, Amparo; Vila Descals, Carlos; Muñoz, M. Carmen; Pedro, José Ramón; Blay Llinares, Gonzalo Perfil
	This document is a artículoDate2021
	An enantioselective organocatalytic addition of sodium bisulfite to (E)-nitroalkenes has been developed by using a chiral bifunctional organocatalyst. The present methodology provides a variety of chiral β-nitroethanesulfonic acid compounds (17 examples) with excellent results: up to 99% yield and excellent enantioselectivity (up to 96% ee). The reaction tolerates (hetero)aryl and alkyl substituents on the β-nitroalkenes, and β,β-disubstituted nitroalkenes.
	Sheikhi, Ehsan Rezaei, Narjes Castilla, Alvaro Sanz Marco, Amparo Vila Descals, Carlos Muñoz, M. Carmen Pedro, José Ramón Blay Llinares, Gonzalo 2021 Enantioselective addition of sodium bisulfite to nitroalkenes. A convenient approach to chiral sulfonic acids European Journal of Organic Chemistry 2021 37 5284 5287
	https://doi.org/10.1002/ejoc.202101064

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