Spectral Clustering Reveals Different Profiles of Central Sensitization in Women with Carpal Tunnel Syndrome
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Spectral Clustering Reveals Different Profiles of Central Sensitization in Women with Carpal Tunnel Syndrome

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Spectral Clustering Reveals Different Profiles of Central Sensitization in Women with Carpal Tunnel Syndrome

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dc.contributor.author Pellicer Valero, Oscar José
dc.contributor.author Martín Guerrero, José David
dc.contributor.author Fernández de las Peñas, César
dc.contributor.author Llave Rincón, Ana Isabel de la
dc.contributor.author Rodríguez Jiménez, Jorge
dc.contributor.author Navarro Pardo, Esperanza
dc.contributor.author Cigarán Méndez, Margarita I.
dc.date.accessioned 2021-09-24T07:43:00Z
dc.date.available 2021-09-24T07:43:00Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/10550/80357
dc.description.abstract Identification of subgroups of patients with chronic pain provides meaningful insights into the characteristics of a specific population, helping to identify individuals at risk of chronification and to determine appropriate therapeutic strategies. This paper proposes the use of spectral clustering (SC) to distinguish subgroups (clusters) of individuals with carpal tunnel syndrome (CTS), making use of the obtained patient profiling to argue about potential management implications. SC is a powerful algorithm that builds a similarity graph among the data points (the patients), and tries to find the subsets of points that are strongly connected among themselves, but weakly connected to others. It was chosen due to its advantages with respect to other simpler clustering techniques, such as k-means, and the fact that it has been successfully applied to similar problems. Clinical (age, duration of symptoms, pain intensity, function, and symptom severity), psycho-physical (pressure pain thresholds¿PPTs¿over the three main nerve trunks of the upper extremity, cervical spine, carpal tunnel, and tibialis anterior), psychological (depressive levels), and motor (pinch tip grip force) variables were collected in 208 women with clinical/electromyographic diagnosis of CTS, whose symptoms usually started unilaterally but eventually evolved into bilateral symmetry. SC was used to identify clusters of patients without any previous assumptions, yielding three clusters. Patients in cluster 1 exhibited worse clinical features, higher widespread pressure pain hyperalgesia, higher depressive levels, and lower pinch tip grip force than the other two. Patients in cluster 2 showed higher generalized thermal pain hyperalgesia than the other two. Cluster 0 showed less hypersensitivity to pressure and thermal pain, less severe clinical features, and more normal motor output (tip grip force). The presence of subgroups of individuals with different altered nociceptive processing (one group being more sensitive to pressure pain and another group more sensitive to thermal pain) could lead to different therapeutic programs.
dc.language.iso eng
dc.relation.ispartof Symmetry-Basel, 2021, vol. 13, num. 6 , p. 1042
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Pellicer Valero, Oscar José Martín Guerrero, José David Fernández de las Peñas, César Llave Rincón, Ana Isabel de la Rodríguez Jiménez, Jorge Navarro Pardo, Esperanza Cigarán Méndez, Margarita I. 2021 Spectral Clustering Reveals Different Profiles of Central Sensitization in Women with Carpal Tunnel Syndrome Symmetry-Basel 13 6 1042
dc.subject Dones Malalties
dc.title Spectral Clustering Reveals Different Profiles of Central Sensitization in Women with Carpal Tunnel Syndrome
dc.type info:eu-repo/semantics/article
dc.date.updated 2021-09-24T07:43:01Z
dc.identifier.doi https://doi.org/10.3390/sym13061042
dc.identifier.idgrec 147304

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