Role of miRNA in the Regulatory Mechanisms of Estrogens in Cardiovascular Ageing
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Role of miRNA in the Regulatory Mechanisms of Estrogens in Cardiovascular Ageing

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Role of miRNA in the Regulatory Mechanisms of Estrogens in Cardiovascular Ageing

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dc.contributor.author Pérez Cremades, Daniel
dc.contributor.author Mompeón, Ana
dc.contributor.author Vidal-Gómez, Xavier
dc.contributor.author Hermenegildo, Carlos
dc.contributor.author Novella, Susana
dc.date.accessioned 2021-09-06T07:33:06Z
dc.date.available 2021-09-06T07:33:06Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/10550/80242
dc.description.abstract Cardiovascular diseases are a worldwide health problem and are the leading cause of mortality in developed countries. Together with experimental data, the lower incidence of cardiovascular diseases in women than in men of reproductive age points to the influence of sex hormones at the cardiovascular level and suggests that estrogens play a protective role against cardiovascular disease and that this role is also modified by ageing. Estrogens affect cardiovascular function via their specific estrogen receptors to trigger gene expression changes at the transcriptional level. In addition, emerging studies have proposed a role for microRNAs in the vascular effects mediated by estrogens. miRNAs regulate gene expression by repressing translational processes and have been estimated to be involved in the regulation of approximately 30% of all protein-coding genes in mammals. In this review, we highlight the current knowledge of the role of estrogen-sensitive miRNAs, and their influence in regulating vascular ageing.
dc.language.iso eng
dc.relation.ispartof Oxidative Medicine And Cellular Longevity, 2018, p. 6082387
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Pérez Cremades, Daniel Mompeón, Ana Vidal-Gómez, Xavier Hermenegildo, Carlos Novella, Susana 2018 Role of miRNA in the Regulatory Mechanisms of Estrogens in Cardiovascular Ageing Oxidative Medicine And Cellular Longevity 6082387
dc.subject Fisiologia
dc.subject Sistema cardiovascular
dc.title Role of miRNA in the Regulatory Mechanisms of Estrogens in Cardiovascular Ageing
dc.type info:eu-repo/semantics/article
dc.date.updated 2021-09-06T07:33:07Z
dc.identifier.doi https://doi.org/10.1155/2018/6082387
dc.identifier.idgrec 130189

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