The role of NF-kB triggered inflammation in cerebral ischemia
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The role of NF-kB triggered inflammation in cerebral ischemia

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The role of NF-kB triggered inflammation in cerebral ischemia

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dc.contributor.author Jover Mengual, Teresa
dc.contributor.author Hwang, Jee-Yeon
dc.contributor.author Byun, Hyae-Ran
dc.contributor.author Court-Vazquez, Brenda L.
dc.contributor.author Centeno Guil, José M.
dc.contributor.author Burguete, Maria C.
dc.contributor.author Zukin, R. Suzanne
dc.date.accessioned 2021-09-01T14:18:36Z
dc.date.available 2021-09-01T14:18:36Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/10550/80183
dc.description.abstract Cerebral ischemia is a devastating disease that affects many people worldwide every year. The neurodegenerative damage as a consequence of oxygen and energy deprivation, to date, has no known effective treatment. The ischemic insult is followed by an inflammatory response that involves a complex interaction between inflammatory cells and molecules which play a role in the progression towards cell death. However, there is presently a matter of controversy over whether inflammation could either be involved in brain damage or be a necessary part of brain repair. The inflammatory response is triggered by inflammasomes, key multiprotein complexes that promote secretion of pro-inflammatory cytokines. An early event in post-ischemic brain tissue is the release of certain molecules and reactive oxygen species (ROS) from injured neurons which induce the expression of the nuclear factor-kappaB (NF-kB), a transcription factor involved in the activation of the inflammasome. There are conflicting observations related to the role of NF-kB. While some observe that NF-kB plays a damaging role, others suggest it to be neuroprotective in the context of cerebral ischemia, indicating the need for additional investigation. Here we discuss the dual role of the major inflammatory signaling pathways and provide a review of the latest research aiming to clarify the relationship between NF- kB mediated inflammation and neuronal death in cerebral ischemia.
dc.language.iso eng
dc.relation.ispartof Frontiers In Cellular Neuroscience, 2021, vol. 15, num. 633610, p. 1-8
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Jover Mengual, Teresa Hwang, Jee-Yeon Byun, Hyae-Ran Court-Vazquez, Brenda L. Centeno Guil, José M. Burguete, Maria C. Zukin, R. Suzanne 2021 The role of NF-kB triggered inflammation in cerebral ischemia Frontiers In Cellular Neuroscience 15 633610 1 8
dc.subject Cervell Ferides i lesions
dc.subject Oxigen Efectes fisiològics
dc.title The role of NF-kB triggered inflammation in cerebral ischemia
dc.type info:eu-repo/semantics/article
dc.date.updated 2021-09-01T14:18:36Z
dc.identifier.doi https://doi.org/10.3389/fncel.2021.633610
dc.identifier.idgrec 147644

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