The evolution and changing ecology of the African hominid oral microbiome
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The evolution and changing ecology of the African hominid oral microbiome

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The evolution and changing ecology of the African hominid oral microbiome

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dc.contributor.author Salazar García, Domingo Carlos
dc.contributor.author Velsko I.M.
dc.contributor.author Aron F.
dc.contributor.author Posth C.
dc.contributor.author Hofmam C.A.
dc.contributor.author Austin R.M.
dc.contributor.author Parker C.E.
dc.contributor.author Mann A.E.
dc.contributor.author Nägale K.
dc.contributor.author Weedman Arthur K.
dc.contributor.author Arthur J.W.
dc.contributor.author Bauer C.C.
dc.contributor.author Crevecoeur I.
dc.contributor.author Cupillard C.
dc.contributor.author Curtis M.C.
dc.contributor.author Dalén L.
dc.contributor.author Díaz-Zorita Bonilla M.
dc.contributor.author Díez Fernández Lomana J.C.
dc.contributor.author Drucker D.G.
dc.contributor.author Escribano Escrivá E.
dc.contributor.author Francken M.
dc.contributor.author Gibbon V.E.
dc.contributor.author González Morales M.R.
dc.contributor.author Grande Mateu A.
dc.contributor.author Harvati K.
dc.contributor.author Henry A.G.
dc.contributor.author Humphrey L.
dc.contributor.author Menéndez M.
dc.contributor.author Mihailovic D.
dc.contributor.author Peresani M.
dc.contributor.author Rodríguez Moroder S.
dc.contributor.author Roksandic M.
dc.contributor.author Rougier H.
dc.contributor.author Sázelová S.
dc.contributor.author Stock J.T.
dc.contributor.author Guy Strauss L.
dc.contributor.author Svooboda J.
dc.contributor.author Tessmann B.
dc.contributor.author Walker M.J.
dc.contributor.author Power R.C.
dc.date.accessioned 2021-09-01T07:56:13Z
dc.date.available 2021-09-01T07:56:13Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/10550/80147
dc.description.abstract The oral microbiome plays key roles in human biology, health, and disease, but little is known about the global diversity, variation, or evolution of this microbial community. To better understand the evolution and changing ecology of the human oral microbiome, we analyzed 124 dental biofilm metagenomes from humans, including Neanderthals and Late Pleistocene to present-day modern humans, chimpanzees, and gorillas, as well as New World howler monkeys for comparison. We find that a core microbiome of primarily biofilm structural taxa has been maintained throughout African hominid evolution, and these microbial groups are also shared with howler monkeys, suggesting that they have been important oral members since before the catarrhine-platyrrhine split ca. 40 Mya. However, community structure and individual microbial phylogenies do not closely reflect host relationships, and the dental biofilms of Homo and chimpanzees are distinguished by major taxonomic and functional differences. Reconstructing oral metagenomes from up to 100 thousand years ago, we show that the microbial profiles of both Neanderthals and modern humans are highly similar, sharing functional adaptations in nutrient metabolism. These include an apparent Homo-specific acquisition of salivary amylase-binding capability by oral streptococci, suggesting microbial coadaptation with host diet. We additionally find evidence of shared genetic diversity in the oral bacteria of Neanderthal and Upper Paleolithic modern humans that is not observed in later modern human populations. Differences in the oral microbiomes of African hominids provide insights into human evolution, the ancestral state of the human microbiome, and a temporal framework for understanding microbial health and disease.
dc.language.iso eng
dc.relation.ispartof Proceedings of the National Academy of Sciences of the United States of America, 2021, vol. 118, num. 20, p. e2021655118
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Salazar García, Domingo Carlos Velsko I.M. Aron F. Posth C. Hofmam C.A. Austin R.M. Parker C.E. Mann A.E. Nägale K. Weedman Arthur K. Arthur J.W. Bauer C.C. Crevecoeur I. Cupillard C. Curtis M.C. Dalén L. Díaz-Zorita Bonilla M. Díez Fernández Lomana J.C. Drucker D.G. Escribano Escrivá E. Francken M. Gibbon V.E. González Morales M.R. Grande Mateu A. Harvati K. Henry A.G. Humphrey L. Menéndez M. Mihailovic D. Peresani M. Rodríguez Moroder S. Roksandic M. Rougier H. Sázelová S. Stock J.T. Guy Strauss L. Svooboda J. Tessmann B. Walker M.J. Power R.C. 2021 The evolution and changing ecology of the African hominid oral microbiome Proceedings of the National Academy of Sciences of the United States of America 118 20 e2021655118
dc.subject Prehistòria
dc.title The evolution and changing ecology of the African hominid oral microbiome
dc.type info:eu-repo/semantics/article
dc.date.updated 2021-09-01T07:56:13Z
dc.identifier.doi https://doi.org/10.1073/pnas.2021655118
dc.identifier.idgrec 147550

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