Early Parental Death and Risk of Psychosis in Offspring: A Six-Country Case-Control Study
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Early Parental Death and Risk of Psychosis in Offspring: A Six-Country Case-Control Study

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Early Parental Death and Risk of Psychosis in Offspring: A Six-Country Case-Control Study

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dc.contributor.author Misra, Supriya
dc.contributor.author Gelaye, Bizu
dc.contributor.author Koenen, Karestan C.
dc.contributor.author Williams, David R.
dc.contributor.author Borba, Christina
dc.contributor.author Quattrone, Diego
dc.contributor.author Di Forti, Marta
dc.contributor.author La Cascia, Caterina
dc.contributor.author La Barbera, Daniele
dc.contributor.author Tarricone, Ilaria
dc.contributor.author Berardi, Domenico
dc.contributor.author Szoke, Andrei
dc.contributor.author Arango, Celso
dc.contributor.author Tortelli, Andrea
dc.contributor.author De Haan, Lieuwe
dc.contributor.author Velthorst, Eva
dc.contributor.author Bobes, Julio
dc.contributor.author Bernardo, Miguel
dc.contributor.author Sanjuán Arias, Julio
dc.contributor.author Santos, Jose Luis
dc.contributor.author Arrojo, Manuel
dc.contributor.author Del‑Ben, Cristina Marta
dc.contributor.author Menezes, Paulo Rossi
dc.contributor.author Selten, Jean-Paul
dc.contributor.author Jones, Peter B.
dc.contributor.author Kirkbride, James B.
dc.contributor.author Rutten, Bart P.F.
dc.contributor.author van Os, J.
dc.contributor.author Murray, Robin
dc.contributor.author Gayer-Anderson, Charlotte
dc.contributor.author Morgan, Craig
dc.date.accessioned 2021-07-27T17:04:03Z
dc.date.available 2021-07-27T17:04:03Z
dc.date.issued 2019
dc.identifier.uri https://hdl.handle.net/10550/80047
dc.description.abstract Evidence for early parental death as a risk factor for psychosis in offspring is inconclusive. We analyzed data from a six-country, case-control study to examine the associations of early parental death, type of death (maternal, paternal, both), and child's age at death with psychosis, both overall and by ethnic group. In fully adjusted multivariable mixed-effects logistic regression models, experiencing early parental death was associated with 1.54-fold greater odds of psychosis (95% confidence interval (CI): 1.23, 1.92). Experiencing maternal death had 2.27-fold greater odds (95% CI: 1.18, 4.37), paternal death had 1.14-fold greater odds (95% CI: 0.79, 1.64), and both deaths had 4.42-fold greater odds (95% CI: 2.57, 7.60) of psychosis compared with no early parental death. Experiencing parental death between 11 and 16 years of age had 2.03-fold greater odds of psychosis than experiencing it before five years of age (95% CI: 1.02, 4.04). In stratified analyses, experiencing the death of both parents had 9.22-fold greater odds of psychosis among minority ethnic groups (95% CI: 2.02-28.02) and no elevated odds among the ethnic majority (odds ratio (OR): 0.96; 95% CI: 0.10-8.97), which could be due in part to the higher prevalence of early parental death among minority ethnic groups but should be interpreted cautiously given the wide confidence intervals.
dc.relation.ispartof Journal Of Clinical Medicine, 2019, vol. 8, num. 7, p. 1081
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Misra, Supriya Gelaye, Bizu Koenen, Karestan C. Williams, David R. Borba, Christina Quattrone, Diego Di Forti, Marta La Cascia, Caterina La Barbera, Daniele Tarricone, Ilaria Berardi, Domenico Szoke, Andrei Arango, Celso Tortelli, Andrea De Haan, Lieuwe Velthorst, Eva Bobes, Julio Bernardo, Miguel Sanjuán Arias, Julio Santos, Jose Luis Arrojo, Manuel Del&#8209Ben, Cristina Marta Menezes, Paulo Rossi Selten, Jean-Paul Jones, Peter B. Kirkbride, James B. Rutten, Bart P.F. van Os, J. Murray, Robin Gayer-Anderson, Charlotte Morgan, Craig 2019 Early Parental Death and Risk of Psychosis in Offspring: A Six-Country Case-Control Study Journal Of Clinical Medicine 8 7 1081
dc.subject Psiquiatria
dc.subject Infants Salut mental
dc.subject Esquizofrènia
dc.title Early Parental Death and Risk of Psychosis in Offspring: A Six-Country Case-Control Study
dc.type info:eu-repo/semantics/article
dc.date.updated 2021-07-27T17:04:03Z
dc.identifier.doi https://doi.org/10.3390/jcm8071081
dc.identifier.idgrec 145589

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