The role of chemokines in alzheimer's disease
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The role of chemokines in alzheimer's disease

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The role of chemokines in alzheimer's disease

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dc.contributor.author Jorda Vallés, Adrian
dc.contributor.author Campos Campos, Juan
dc.contributor.author Iradi Casal, Antonio
dc.contributor.author Aldasoro Celaya, Martin
dc.contributor.author Aldasoro, Constanza
dc.contributor.author Vila, Jose M
dc.contributor.author Valles Martín, Lilian Soraya
dc.date.accessioned 2021-07-14T07:15:54Z
dc.date.available 2021-07-14T07:15:54Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/10550/79918
dc.description.abstract OBJECTIVE:The most common multifactorial neurodegenerative disorder occurring in old age is Alzheimer's disease. The neuropathological hallmarks of that disorder are amyloid plaques with the presence of β -amyloid aggregates, intraneuronal tau protein tangles, and chronic inflammation. Brain cells such as microglia and astrocytes are inflammatory cells associated with Alzheimer's disease and involved in the production of inflammatory mediators, such as cytokines and chemokines. Chemokines consist of a large family of protein mediators with low molecular weight, which able to control the migration and residence of all immune cells. In pathological conditions, such as Alzheimer's disease, chemokines contribute to the inflammatory response by recruiting T cells and controlling microglia/ macrophages activation. METHODS:The present study focuses on the role that chemokines and their receptors play in Alzheimer's disease and in processes such as inflammation and oxidative stress. RESULTS:Chemokines are important mediators in AD and inflammation. They promote Aβ deposition and TAU hyperphosphorylation aggravating and increasing the progression of AD. Moreover, they affect the processing of senile plaques and produce abnormal TAU phosphorylation. CONCLUSION:There is no cure for AD but the therapeutic potential of chemokines to control the development of the disease may be a field of study to consider in the future.
dc.language.iso eng
dc.relation.ispartof Endocrine Metabolic & Immune Disorders-Drug Targets, 2020
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Jorda Vallés, Adrian Campos Campos, Juan Iradi Casal, Antonio Aldasoro Celaya, Martin Aldasoro, Constanza Vila, Jose M Valles Martín, Lilian Soraya 2020 The role of chemokines in alzheimer's disease Endocrine Metabolic & Immune Disorders-Drug Targets
dc.subject Fisiologia
dc.subject Malalties
dc.title The role of chemokines in alzheimer's disease
dc.type info:eu-repo/semantics/article
dc.date.updated 2021-07-14T07:15:55Z
dc.identifier.idgrec 140235

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