First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory Paradigm
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First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory Paradigm

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First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory Paradigm

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dc.contributor.author González Vivas, Carlos
dc.contributor.author García Martí, Gracián
dc.contributor.author Soldevila Matías, Pablo
dc.contributor.author Sanz-Requena, Roberto
dc.contributor.author Aguilar, Eduardo J.
dc.contributor.author Castro Bleda, María José
dc.contributor.author Martí Bonmatí, Luis
dc.contributor.author Sanjuán Arias, Julio
dc.date.accessioned 2021-05-04T16:21:54Z
dc.date.available 2021-05-04T16:21:54Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/10550/79103
dc.description.abstract Most previous longitudinal studies of functional magnetic resonance imaging (fMRI) in first-episode psychosis (FEP) using cognitive paradigm task found an increased activation after antipsychotic medications. We designed an emotional auditory paradigm to explore brain activation during emotional and nonemotional word processing. This study aimed to analyze if longitudinal changes in brain fMRI BOLD activation is present in patients vs. healthy controls. A group of FEP patients (n = 34) received clinical assessment and had a fMRI scan at baseline and follow-up (average, 25-month interval). During the fMRI scan, both emotional and nonemotional words were presented as a block design. Results were compared with a pair of healthy control group (n = 13). Patients showed a decreased activation at follow-up fMRI in amygdala (F = 4.69; p = 0.04) and hippocampus (F = 5.03; p = 0.03) compared with controls. Middle frontal gyrus was the only area that showed a substantial increased activation in patients (F = 4.53; p = 0.04). A great heterogeneity in individual activation patterns was also found. These results support the relevance of the type of paradigm in neuroimaging for psychosis. This is, as far as we know, the first longitudinal study with an emotional auditory paradigm in FEP. Our results suggested that the amygdala and hippocampus play a key role in psychotic disease. More studies are needed to understand the heterogeneity of response at individual level.
dc.language.iso eng
dc.relation.ispartof Frontiers In Psychiatry, 2020, vol. 11
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source González Vivas, Carlos García Martí, Gracián Soldevila Matías, Pablo Sanz-Requena, Roberto Aguilar, Eduardo J. Castro Bleda, María José Martí Bonmatí, Luis Sanjuán Arias, Julio 2020 First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory Paradigm Frontiers In Psychiatry 11
dc.subject Psiquiatria
dc.title First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory Paradigm
dc.type info:eu-repo/semantics/article
dc.date.updated 2021-05-04T16:21:55Z
dc.identifier.doi https://doi.org/10.3389/fpsyt.2020.593042
dc.identifier.idgrec 146672

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