Comparative expression of cyclooxygenase 2 and Ki67 in amelanotic and conventional oral melanomas
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Comparative expression of cyclooxygenase 2 and Ki67 in amelanotic and conventional oral melanomas

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Comparative expression of cyclooxygenase 2 and Ki67 in amelanotic and conventional oral melanomas

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dc.contributor.author Soares, Ciro Dantas es
dc.contributor.author Hernández Guerrero, Juan Carlos es
dc.contributor.author Andrade, Bruno Augusto Benevenuto de es
dc.contributor.author Romañach, Mário José es
dc.contributor.author Mosqueda Taylor, Adalberto es
dc.contributor.author Carlos, Román es
dc.contributor.author Macedo, Madja Ruanna Soares es
dc.contributor.author Almeida, Oslei Paes de es
dc.contributor.author Jorge, Jacks es
dc.date.accessioned 2021-05-04T11:01:19Z
dc.date.available 2021-05-04T11:01:19Z
dc.date.issued 2020 es
dc.identifier.uri https://hdl.handle.net/10550/79089
dc.description.abstract Oral melanomas have some histopathological resemblance with its cutaneous counterpart; however, an aggressive behavior is more common in tumors that occur in the oral cavity. Several markers have been suggested as indicative of tumoral progression and aggressiveness, such as cyclooxygenase 2 (COX-2) and Ki67. In this study, we have compared the expression of COX-2 and Ki67 in a series of amelanotic (n=7) and melanotic oral melanomas (n=22). The cases were selected from 4 pathology laboratories and submitted to the immunohistochemical (IHC) reactions. We analyzed the IHC staining based on a qualitative ? using visual scores; and a computer-assisted method (quantitative) using scanned slides and software for digital analysis. COX-2 was expressed in all oral melanomas; however, its intensity was significantly higher in the amelanotic ones (P<0.001). Similarly, a high Ki67-positivity index was observed in the amelanotic than melanotic ones (P<0.001). Based on these results, we suggest that amelanotic oral melanomas have marked pro-inflammatory and high-proliferative phenotype, justifying their more aggressive behavior compared with the melanotic ones. es
dc.source Soares, Ciro Dantas ; Hernández Guerrero, Juan Carlos ; Andrade, Bruno Augusto Benevenuto de ; Romañach, Mário José ; Mosqueda Taylor, Adalberto ; Carlos, Román ; Macedo, Madja Ruanna Soares ; Almeida, Oslei Paes de ; Jorge, Jacks. Comparative expression of cyclooxygenase 2 and Ki67 in amelanotic and conventional oral melanomas. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 25 6 2020: 15- es
dc.title Comparative expression of cyclooxygenase 2 and Ki67 in amelanotic and conventional oral melanomas es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.23737 es

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