Bacteria associated with periodontal disease are also increased in health
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Bacteria associated with periodontal disease are also increased in health

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Bacteria associated with periodontal disease are also increased in health

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dc.contributor.author López-Martínez, Jesús es
dc.contributor.author Chueca, Natalia es
dc.contributor.author Padial Molina, Miguel es
dc.contributor.author Fernandez Caballero Rico, Jose Angel es
dc.contributor.author García Sabán, Francisco es
dc.contributor.author O'valle Ravassa, Francisco Javier es
dc.contributor.author Galindo Moreno, Pablo es
dc.date.accessioned 2021-05-04T11:01:18Z
dc.date.available 2021-05-04T11:01:18Z
dc.date.issued 2020 es
dc.identifier.uri https://hdl.handle.net/10550/79086
dc.description.abstract The objective of this cross-sectional clinical study was to analyze the differences in the microbiome in gingival sulci of adult patients in the presence or absence of chronic periodontitis. Patients with or without periodontal disease were included in this cross-sectional study. Subgingival biofilm samples were collected and analyzed by 16S massive pyrosequencing. Functional analyses were also performed. A total of 15 phyla, 154 genera and 351 species were detected globally. Differences between disease and non-disease samples were observed in all taxonomical levels which suggest functional profile changes in the community. It was found that the main species associated with non-disease samples were reduced in disease but not completely suppressed. Analysis of the functional potential of the biofilms revealed a significantly higher activity related to endocytosis and phosphatidylinositol signaling in the disease group but lower cell adhesion molecules. Specific differences between health and disease suggest functional profile changes in the community, although bacteria associated with periodontal disease are also increased in health. Transcriptome studies should be conducted to confirm and deepen metabolic dysfunctions. es
dc.source López-Martínez, Jesús ; Chueca, Natalia ; Padial Molina, Miguel ; Fernandez Caballero Rico, Jose Angel ; García Sabán, Francisco ; O'valle Ravassa, Francisco Javier ; Galindo Moreno, Pablo. Bacteria associated with periodontal disease are also increased in health. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 25 6 2020: 12- es
dc.title Bacteria associated with periodontal disease are also increased in health es
dc.type info:eu-repo/semantics/article en
dc.type info:eu-repo/semantics/publishedVersion en
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.23766 es

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