Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls: Results from the EUGEI study.
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Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls: Results from the EUGEI study.

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Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls: Results from the EUGEI study.

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dc.contributor.author Erzin, G.
dc.contributor.author Pries, L.K.
dc.contributor.author van Os, J.
dc.contributor.author Fusar-Poli, L.
dc.contributor.author Delespaul, P.
dc.contributor.author Kenis, G.
dc.contributor.author Luykx, J.J.
dc.contributor.author Lin, B.D.
dc.contributor.author Richards, A.L.
dc.contributor.author Akdede, B.
dc.contributor.author Binbay, T.
dc.contributor.author Altınyazar, V.
dc.contributor.author Yalınçetin, B.
dc.contributor.author Gümüş-Akay, G.
dc.contributor.author Cihan, B.
dc.contributor.author Soygür, H.
dc.contributor.author Ulaş, H.
dc.contributor.author Cankurtaran, E.Ş.
dc.contributor.author Kaymak, S.U.
dc.contributor.author Mihaljevic, M.M.
dc.contributor.author Andric-Petrovic, S.
dc.contributor.author Mirjanic, T.
dc.contributor.author Bernardo, Miguel
dc.contributor.author Mezquida, Gisel
dc.contributor.author Amoretti, Silvia
dc.contributor.author Bobes, Julio
dc.contributor.author Saiz, Pilar
dc.contributor.author García-Portilla, Maria Paz
dc.contributor.author Sanjuán Arias, Julio
dc.contributor.author Aguilar, Eduardo J.
dc.contributor.author Santos, Jose Luis
dc.contributor.author Jiménez-López, Estela
dc.contributor.author Arrojo, Manuel
dc.contributor.author Carracedo, Angel
dc.contributor.author López, Gonzalo
dc.contributor.author González-Peñas, Javier
dc.contributor.author Parellada, Mara
dc.contributor.author Maric, N.P.
dc.contributor.author Atbaşoğlu, C.
dc.contributor.author Ucok, A.
dc.date.accessioned 2021-05-04T10:43:31Z
dc.date.available 2021-05-04T10:43:31Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/10550/79071
dc.description.abstract Background. A cumulative environmental exposure score for schizophrenia (exposome score for schizophrenia [ES-SCZ]) may provide potential utility for risk stratification and outcome prediction. Here, we investigated whether ES-SCZ was associated with functioning in patients with schizophrenia spectrum disorder, unaffected siblings, and healthy controls. Methods. This cross-sectional sample consisted of 1,261 patients, 1,282 unaffected siblings, and 1,525 healthy controls. The Global Assessment of Functioning (GAF) scale was used to assess functioning. ES-SCZ was calculated based on our previously validated method. The association between ES-SCZ and the GAF dimensions (symptom and disability) was analyzed by applying regression models in each group (patients, siblings, and controls). Additional models included polygenic risk score for schizophrenia (PRS-SCZ) as a covariate. Results. ES-SCZ was associated with the GAF dimensions in patients (symptom: B = 1.53, p-value = 0.001; disability: B = 1.44, p-value = 0.001), siblings (symptom: B = 3.07, p-value < 0.001; disability: B = 2.52, p-value < 0.001), and healthy controls (symptom: B = 1.50, p-value < 0.001; disability: B = 1.31, p-value < 0.001). The results remained the same after adjusting for PRS-SCZ. The degree of associations of ES-SCZ with both symptom and disability dimensions were higher in unaffected siblings than in patients and controls. By analyzing an independent dataset (the Genetic Risk and Outcome of Psychosis study), we replicated the results observed in the patient group. Conclusions. Our findings suggest that ES-SCZ shows promise for enhancing risk prediction and stratification in research practice. From a clinical perspective, ES-SCZ may aid in efforts of clinical characterization, operationalizing transdiagnostic clinical staging models, and personalizing clinical management.
dc.language.iso eng
dc.relation.ispartof European Psychiatry, 2021
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Erzin, G. Pries, L.K. van Os, J. Fusar-Poli, L. Delespaul, P. Kenis, G. Luykx, J.J. Lin, B.D. Richards, A.L. Akdede, B. Binbay, T. Alt&#305nyazar, V. Yal&#305nçetin, B. Gümü&#351-Akay, G. Cihan, B. Soygür, H. Ula&#351, H. Cankurtaran, E.&#350. Kaymak, S.U. Mihaljevic, M.M. Andric-Petrovic, S. Mirjanic, T. Bernardo, Miguel Mezquida, Gisel Amoretti, Silvia Bobes, Julio Saiz, Pilar García-Portilla, Maria Paz Sanjuan Arias, Julio Aguilar, Eduardo J. Santos, Jose Luis Jiménez-López, Estela Arrojo, Manuel Carracedo, Angel López, Gonzalo González-Peñas, Javier Parellada, Mara Maric, N.P. Atba&#351o&#287lu, C. Ucok, A. 2021 Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls: Results from the EUGEI study. European Psychiatry
dc.subject Psiquiatria
dc.title Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls: Results from the EUGEI study.
dc.type info:eu-repo/semantics/article
dc.date.updated 2021-05-04T10:43:31Z
dc.identifier.doi https://doi.org/10.1192/j.eurpsy.2021.19
dc.identifier.idgrec 146670

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