Viral Bcl2s' transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis
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Viral Bcl2s' transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis

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Viral Bcl2s' transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis

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dc.contributor.author García Murria, María Jesús
dc.contributor.author Duart, Gerard
dc.contributor.author Grau, Brayan
dc.contributor.author Diaz-Beneitez, Elisabet
dc.contributor.author Rodríguez, Dolores
dc.contributor.author Mingarro Muñoz, Ismael
dc.contributor.author Martínez Gil, Luis
dc.date.accessioned 2021-04-27T12:45:29Z
dc.date.available 2021-04-27T12:45:29Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/10550/78942
dc.description.abstract Viral control of programmed cell death relies in part on the expression of viral analogs of the B-cell lymphoma 2 (Bcl2) protein known as viral Bcl2s (vBcl2s). vBcl2s control apoptosis by interacting with host pro- and anti-apoptotic members of the Bcl2 family. Here, we show that the carboxyl-terminal hydrophobic region of herpesviral and poxviral vBcl2s can operate as transmembrane domains (TMDs) and participate in their homo-oligomerization. Additionally, we show that the viral TMDs mediate interactions with cellular pro- and anti-apoptotic Bcl2 TMDs within the membrane. Furthermore, these intra-membrane interactions among viral and cellular proteins are necessary to control cell death upon an apoptotic stimulus. Therefore, their inhibition represents a new potential therapy against viral infections, which are characterized by short- and long-term deregulation of programmed cell death.
dc.language.iso eng
dc.relation.ispartof Nature Communications, 2020, vol. 11, num. 6056
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source García Murria, María Jesús Duart, Gerard Grau, Brayan Diaz-Beneitez, Elisabet Rodríguez, Dolores Mingarro Muñoz, Ismael Martínez Gil, Luis 2020 Viral Bcl2s' transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis Nature Communications 11 6056
dc.subject Proteïnes
dc.subject Virus
dc.title Viral Bcl2s' transmembrane domain interact with host Bcl2 proteins to control cellular apoptosis
dc.type info:eu-repo/semantics/article
dc.date.updated 2021-04-27T12:45:29Z
dc.identifier.doi https://doi.org/10.1038/s41467-020-19881-9
dc.identifier.idgrec 141636

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