Exposure to mercury among 9-year-old children and neurobehavioural function
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Exposure to mercury among 9-year-old children and neurobehavioural function

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Exposure to mercury among 9-year-old children and neurobehavioural function

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dc.contributor.author Lozano, Manuel
dc.contributor.author Murcia, Mario
dc.contributor.author Soler-Blasco, Raquel
dc.contributor.author González, Llúcia
dc.contributor.author Iriarte, Gorka
dc.contributor.author Rebagliato, Marisa
dc.contributor.author López-Espinosa, Maria-José
dc.contributor.author Esplugues, Ana
dc.contributor.author Ballester, Ferran
dc.contributor.author Llop, Sabrina
dc.contributor.author Sabrina Llop
dc.date.accessioned 2021-04-27T07:33:27Z
dc.date.available 2021-04-27T07:33:27Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/10550/78932
dc.description.abstract Mercury (Hg) is an environmental neurotoxicant whose main route of exposure in humans is the consumption of seafood. The aim of this study was to explore the relationship between Hg exposure at 9 years old and behaviour assessed at 9 and 11 years old. Study subjects were mother-child pairs participating in the INMA (Environment and Childhood) Project in Valencia (Spain). Total Hg (THg) was measured in hair samples from the children at 9 years old. Behaviour and emotions were assessed at 9 (n = 472) years and 11 (n = 385) years of age using the Child Behaviour Checklist test (CBCL) and the Conners Parents Rating Scale-Revised: Short Form (CPRS-R:S). Furthermore, the attention function was assessed by the Attention Network Test at 11 years old. Socio-demographic, lifestyle and dietary information was collected through questionnaires during pregnancy and childhood. Polymorphism in BDNF, APOE and GSTP1 were genotyped in cord blood DNA. Multivariable negative binomial regression models were built in order to study the association between THg concentrations and the scores obtained by the children at 9 and 11 years old. Effect modification by sex and genetic polymorphisms was assessed. The association between Hg levels and CBCL scores was positive (worse neurobehavioural development) for the CBCL internalizing and total problem scales (Incidence Rate Ratio [95% confidence interval] = 1.07 [1.01,1.13] and 1.05 [0.99, 1.11], respectively). The association between Hg and the externalizing and total problems CBCL scales and the Attention Deficit Hyperactivity Disorder (ADHD) index of the CPRS-R:S was different according to sex, with boys obtaining worse scores with increasing Hg, compared to girls. Statistically significant interactions were also observed for genetic polymorphisms affecting the association between early exposure to Hg and both CBCL and CPRS-R:S scores. In conclusion, postnatal Hg exposure is associated with poorer neurobehavioural development in 9- and 11-year-old children. Sex and the presence of certain genetic polymorphisms modified this association.
dc.language.iso eng
dc.relation.ispartof Environment International, 2020, vol. 146, num. 106173
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Lozano, Manuel Murcia, Mario Soler-Blasco, Raquel González, Llúcia Iriarte, Gorka Rebagliato, Marisa López-Espinosa, Maria-José Esplugues, Ana Ballester, Ferran Llop, Sabrina Sabrina Llop 2020 Exposure to mercury among 9-year-old children and neurobehavioural function Environment International 146 106173
dc.subject Neurologia pediàtrica
dc.title Exposure to mercury among 9-year-old children and neurobehavioural function
dc.type info:eu-repo/semantics/article
dc.date.updated 2021-04-27T07:33:27Z
dc.identifier.doi https://doi.org/10.1016/j.envint.2020.106173
dc.identifier.idgrec 140939

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