Structure and function of the vacuolar Ccc1/VIT1 family of iron transporters and its regulation in fungi
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Structure and function of the vacuolar Ccc1/VIT1 family of iron transporters and its regulation in fungi

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Structure and function of the vacuolar Ccc1/VIT1 family of iron transporters and its regulation in fungi

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dc.contributor.author Sorribes-Dauden, Raquel
dc.contributor.author Peris Navarro, David
dc.contributor.author Martínez Pastor, María Teresa
dc.contributor.author Puig Todolí, Sergi
dc.date.accessioned 2021-04-26T15:57:12Z
dc.date.available 2021-04-26T15:57:12Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/10550/78921
dc.description.abstract Iron is an essential micronutrient for most living beings since it participates as a redox active cofactor in many biological processes including cellular respiration, lipid biosynthesis, DNA replication and repair, and ribosome biogenesis and recycling. However, when present in excess, iron can participate in Fenton reactions and generate reactive oxygen species that damage cells at the level of proteins, lipids and nucleic acids. Organisms have developed different molecular strategies to protect themselves against the harmful effects of high concentrations of iron. In the case of fungi and plants, detoxification mainly occurs by importing cytosolic iron into the vacuole through the Ccc1/VIT1 iron transporter. New sequenced genomes and bioinformatic tools are facilitating the functional characterization, evolution and ecological relevance of metabolic pathways and homeostatic networks across the Tree of Life. Sequence analysis shows that Ccc1/VIT1 homologs are widely distributed among organisms with the exception of animals. The recent elucidation of the crystal structure of a Ccc1/VIT1 plant ortholog has enabled the identification of both conserved and species-specific motifs required for its metal transport mechanism. Moreover, recent studies in the yeast Saccharomyces cerevisiae have also revealed that multiple transcription factors including Yap5 and Msn2/Msn4 contribute to the expression of CCC1 in high-iron conditions. Interestingly, Malaysian S. cerevisiae strains express a partially functional Ccc1 protein that renders them sensitive to iron. Different regulatory mechanisms have been described for non-Saccharomycetaceae Ccc1 homologs. The characterization of Ccc1/VIT1 proteins is of high interest in the development of biofortified crops and the protection against microbial-derived diseases.
dc.language.iso eng
dc.relation.ispartof Computational And Structural Biotechnology Journal, 2020, vol. 18, p. 3712-3722
dc.rights.uri info:eu-repo/semantics/openAccess
dc.source Sorribes-Dauden, Raquel Peris Navarro, David Martínez Pastor, María Teresa Puig Todolí, Sergi 2020 Structure and function of the vacuolar Ccc1/VIT1 family of iron transporters and its regulation in fungi Computational And Structural Biotechnology Journal 18 3712 3722
dc.subject Fongs
dc.subject Ferro
dc.subject Biotecnologia
dc.title Structure and function of the vacuolar Ccc1/VIT1 family of iron transporters and its regulation in fungi
dc.type info:eu-repo/semantics/article
dc.date.updated 2021-04-26T15:57:12Z
dc.identifier.doi https://doi.org/10.1016/j.csbj.2020.10.044
dc.identifier.idgrec 145781

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